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Karoline Kuchenbaecker
University College London
20Publications
3H-index
28Citations
Publications 20
Newest
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Sara Lindstroem (UW: University of Washington)H-Index: 43
view all 333 authors...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Sara Lindstroem (UW: University of Washington)H-Index: 43
view all 333 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Arthur GillyH-Index: 9
#2Lorraine Southam (University of Oxford)H-Index: 23
Last.Eleftheria ZegginiH-Index: 69
view all 17 authors...
Motivation: Very low depth sequencing has been proposed as a cost-effective approach to capture low-frequency and rare variation in complex trait association studies. However, a full characterisation of the genotype quality and association power for very low depth sequencing designs is still lacking. Results: We perform cohort-wide whole genome sequencing (WGS) at low depth in 1,239 individuals (990 at 1x depth and 249 at 4x depth) from an isolated population, and establish a robust pipeline for...
#1Sonia Shah (UCL: University College London)H-Index: 34
#2Albert Henry (UCL: University College London)
Last.R Thomas Lumbers (UCL: University College London)H-Index: 1
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Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent associations with HF at 11 genomic loci, all of which demonstrate on...
#1Karen Stanley (UPMC St. Margaret)H-Index: 1
#2Tim Whitfield (UPMC St. Margaret)
Last.Zuzana Walker (UPMC St. Margaret)H-Index: 38
view all 6 authors...
#1Nikita Telkar (UCL: University College London)
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
view all 22 authors...
The under-representation of non-European samples in genome-wide association studies could ultimately restrict who benefits from medical advances through genomic science. Our aim was therefore to address the fundamental question whether causal variants for blood lipids are shared across populations. A polygenic score based on established LDL-cholesterol-associated loci from European discovery samples had consistent effects on serum levels in samples from the UK, Uganda and Greek population isolat...
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