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David German
Oregon Health & Science University
14Publications
1H-index
4Citations
Publications 15
Newest
Background The risk of sudden cardiac death (SCD) is known to be dynamic. However, the accuracy of a dynamic SCD prediction is unknown. We aimed to measure the dynamic predictive accuracy of ECG biomarkers of SCD and competing non-sudden cardiac death (non-SCD).
Source
#1Stacey J. Howell (OHSU: Oregon Health & Science University)H-Index: 3
#2Erick A. Perez-Alday (OHSU: Oregon Health & Science University)H-Index: 3
Last.Larisa G. Tereshchenko (OHSU: Oregon Health & Science University)H-Index: 20
view all 7 authors...
Source
#1Erick A. Perez-Alday (OHSU: Oregon Health & Science University)H-Index: 3
#2Kazi Haq (OHSU: Oregon Health & Science University)
Last.Larisa G. Tereshchenko (OHSU: Oregon Health & Science University)H-Index: 20
view all 15 authors...
Background: Mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy (HCM) are not well understood. We hypothesized that HCM is characterized by the specific electrophysiological substrate as compared to patients with ischemic cardiomyopathy (ICM), or healthy individuals. Methods: We conducted a prospective case-control study. HCM patients at high risk for ventricular tachyarrhythmia (VT) (n=10; age 61 ± 9 y; left ventricular ejection fraction (LVEF) 60 ± 9%) and three control groups (Heal...
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#1Stacey J. Howell (OHSU: Oregon Health & Science University)H-Index: 3
#2David German (OHSU: Oregon Health & Science University)H-Index: 1
Last.Larisa G. Tereshchenko (Johns Hopkins University)H-Index: 20
view all 12 authors...
Background: Sex is a well-recognized risk factor for sudden cardiac death (SCD). Sex differences in electrophysiological (EP) substrate of SCD are known. However, it remains unknown whether sex can modify an association of EP substrate with SCD. Methods: Participants from the Atherosclerosis Risk in Communities study with analyzable ECGs (n=14,725; age, 54.2 +/- 5.8 yrs; 55% female, 74% white) were included. EP substrate was characterized by traditional 12-lead ECG (heart rate, QRS, QTc, Cornell...
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#1Jason Thomas (OHSU: Oregon Health & Science University)H-Index: 4
#2Erick A. Perez-Alday (OHSU: Oregon Health & Science University)H-Index: 3
Last.Larisa G. Tereshchenko (OHSU: Oregon Health & Science University)H-Index: 20
view all 9 authors...
3 CitationsSource
#1David German (Cardiovascular Institute of the South)H-Index: 1
#2Shoukhrat Mitalipov (Cardiovascular Institute of the South)H-Index: 36
Last.Sanjiv Kaul (Cardiovascular Institute of the South)H-Index: 82
view all 4 authors...
Summary A variety of genetic cardiovascular diseases may one day be curable using gene editing technology. Germline genome editing and correction promises to permanently remove monogenic cardiovascular disorders from the offspring and subsequent generations of affected families. Although technically feasible and likely to be ready for implementation in humans in the near future, this approach remains ethically controversial. Although currently beset by several technical challenges, and not yet p...
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#1Erick A. Perez-Alday (OHSU: Oregon Health & Science University)H-Index: 3
#2Aron Bender (OHSU: Oregon Health & Science University)H-Index: 2
Last.Larisa G. Tereshchenko (OHSU: Oregon Health & Science University)H-Index: 20
view all 9 authors...
Background: The risk of sudden cardiac death (SCD) is known to be dynamic. However, an accuracy of a dynamic SCD prediction, and expiration date of ECG biomarkers is unknown. Our goal was to measure dynamic predictive accuracy of ECG biomarkers of SCD and competing outcomes. Methods: Atherosclerosis Risk In Community study participants with analyzable digital ECGs were included (n=15,768; 55% female, 73% white, age 54.2±5.8 y). ECGs of 5 follow-up visits were analyzed. Global electrical heteroge...
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#1Elise A. Larson (OHSU: Oregon Health & Science University)H-Index: 1
#2David German (OHSU: Oregon Health & Science University)H-Index: 1
Last.Thomas G. DeLoughery (OHSU: Oregon Health & Science University)H-Index: 22
view all 4 authors...
1 CitationsSource
#1Abhishek MaanH-Index: 7
#2David GermanH-Index: 1
Last.Larisa G. TereshchenkoH-Index: 20
view all 14 authors...
Introduction: The association between premature ventricular contractions (PVCs) and Sudden Cardiac Death (SCD) remains controversial. Hypothesis: We hypothesized that PVCs are associated with SCD. ...
#1Aron BenderH-Index: 2
#2Muammar M. KabirH-Index: 11
Last.Larisa G. TereshchenkoH-Index: 20
view all 12 authors...
Introduction: Poincare plot asymmetry has been associated with sustained ventricular tachyarrhythmias, implicating involvement of the autonomic nervous system. An association between sudden cardiac...
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