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Julie Kerr-Conte
French Institute of Health and Medical Research
EndocrinologyIsletTransplantationMedicineBiology
200Publications
40H-index
5,054Citations
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Publications 137
Newest
#1Chiara SaponaroH-Index: 1
Last. Jochen H. M. PrehnH-Index: 58
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#1Julie Kerr-ConteH-Index: 40
#2Julien ThevenetH-Index: 5
Last. François PattouH-Index: 63
view all 9 authors...
A translational discrepancy exists between animal models used for diabetes research and diabetes in man, thus human relevant models must become a priority. We showed that collectively human islet grafts from 26 donors statistically significantly adapted their function and endocrine and β-cell mass to HFD (high fat diet) in vivo in 233 RAG2KO mice. Human islet compensation occurs at 6 weeks and metabolic dysfunction upon chronic ≥10 weeks HFD. Herein, gene expression studies (GeneChip® Human Gene...
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#1Mehdi Maanaoui (French Institute of Health and Medical Research)
#2Mikael Chetboun (French Institute of Health and Medical Research)H-Index: 3
Last. Marc HazzanH-Index: 23
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#2Mikael ChetbounH-Index: 3
Last. Thomas HubertH-Index: 16
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The names of the working groups that collaborated in the study reported in this article were inadvertently omitted from the byline. The corrected byline should …
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#1Chiara Saponaro (French Institute of Health and Medical Research)H-Index: 1
#2Markus Mühlemann (French Institute of Health and Medical Research)H-Index: 1
Last. Caroline Bonner (French Institute of Health and Medical Research)H-Index: 16
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Studies implicating sodium-glucose-cotransporter-2 (SGLT2) inhibitors in glucagon secretion by pancreatic alpha cells reported controversial results. We hypothesized that inter-individual heterogeneity in SGLT2 expression and regulation may impact on glucagon secretion by human alpha cells in response to SGLT2 inhibitors. An unbiased RNA-seq analysis of 207 donors revealed an unprecedented level of heterogeneity of SLC5A2 expression. To determine heterogeneity of SGLT2 expression at the protein ...
6 CitationsSource
#1Rita NanoH-Index: 28
#2Julie Kerr-ConteH-Index: 40
Last. Lorenzo PiemontiH-Index: 50
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Aim.Europe is currently the most active region in the field of pancreatic islet transplantation and many of the leading groups are actually achieving similar good outcomes. Further collaborative advances in the field require the standardization of islet cell product isolation processes and this work
1 CitationsSource
#1Marie-Christine Vantyghem (French Institute of Health and Medical Research)H-Index: 26
#2Mikael Chetboun (French Institute of Health and Medical Research)H-Index: 3
Last. François Pattou (French Institute of Health and Medical Research)H-Index: 63
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OBJECTIVE The long-term outcome of allogenic islet transplantation is unknown. The aim of this study was to evaluate the 10-year outcome of islet transplantation in patients with type 1 diabetes and hypoglycemia unawareness and/or a functioning kidney graft. RESEARCH DESIGN AND METHODS We enrolled in this prospective parallel-arm cohort study 28 subjects with type 1 diabetes who received islet transplantation either alone (ITA) or after a kidney graft (IAK). Islet transplantation consisted of tw...
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#1Chiara Saponaro (French Institute of Health and Medical Research)H-Index: 1
#2Valery Gmyr (French Institute of Health and Medical Research)H-Index: 24
Last. Caroline Bonner (French Institute of Health and Medical Research)H-Index: 16
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Summary The newest classes of anti-diabetic agents include sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor (GLP1R) agonists. The SGLT2 inhibitor dapagliflozin reduces glucotoxicity by glycosuria but elevates glucagon secretion. The GLP1R agonist liraglutide inhibits glucagon; therefore, we hypothesize that the cotreatment of dapagliflozin with liraglutide could reduce hyperglucagonemia and hyperglycemia. Here we use five complementary models: human islet cu...
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#1Rita NanoH-Index: 28
#2J. Kerr-Conte (Lille University of Science and Technology)H-Index: 7
Last. Lorenzo PiemontiH-Index: 50
view all 12 authors...
In December 2018, Diabetes and Diabetologia began requiring authors of papers reporting data obtained from studies on human islets to report critical characteristics of the human islets used for research. The islet community was asked to provide feedback on it. Here is the contribution by the European Consortium for Islet Transplantation.
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#1Adrien PasquierH-Index: 3
#2K. VivotH-Index: 3
Last. Romeo RicciH-Index: 23
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Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress markedly enhances macroautophagy-independent lysosomal degradation of nascent insulin granules. In different model systems of diabetes including of human origin, stress-induced nascent granule degradation (SINGD) contributes to loss of insulin alo...
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