Anna Sebastiani
University of Calabria
GPERCancer researchBreast cancerEstrogen receptorCancer cell
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Publications 5
#1Adele VivacquaH-Index: 23
#2Anna SebastianiH-Index: 3
Last. Marcello MaggioliniH-Index: 44
view all 12 authors...
Estrogens acting through the classic estrogen receptors (ERs) and the G protein estrogen receptor (GPER) regulate the expression of diverse miRNAs, small sequences of non-coding RNA involved in several pathophysiological conditions, including breast cancer. In order to provide novel insights on miRNAs regulation by estrogens in breast tumor, we evaluated the expression of 754 miRNAs by TaqMan Array in ER-negative and GPER-positive SkBr3 breast cancer cells and cancer-associated fibroblasts (CAFs...
3 CitationsSource
#1Maria Francesca Santolla (University of Calabria)H-Index: 16
#2Rosamaria Lappano (University of Calabria)H-Index: 25
Last. Adele Vivacqua (University of Calabria)H-Index: 23
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MicroRNA (miRNAs) are non-coding small RNA molecules that regulate gene expression by inhibiting the translation of target mRNAs. Among several dysregulated miRNAs in human cancer, the up-regulation of miR-221 has been associated with development of a variety of hematologic and solid malignancies. In this study, we investigated the involvement of miR-221 in breast cancer. TaqMan microRNA assay was used to detect the miR-221 levels in normal cells and in MDA-MB 231 and SkBr3 breast cancer cells a...
7 CitationsSource
#1Donatella VizzaH-Index: 12
#2Rosamaria Lappano (University of Calabria)H-Index: 25
Last. Renzo BonofiglioH-Index: 7
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#1Francesca CirilloH-Index: 9
Last. Marcello MaggioliniH-Index: 44
view all 15 authors...
// Francesca Cirillo 1, * , Michele Pellegrino 1, * , Rocco Malivindi 1 , Vittoria Rago 1 , Silvia Avino 1 , Luigina Muto 1 , Vincenza Dolce 1 , Adele Vivacqua 1 , Damiano Cosimo Rigiracciolo 1 , Paola De Marco 1 , Anna Sebastiani 1 , Sergio Abonante 2 , Miki Nakajima 3 , Rosamaria Lappano 1 and Marcello Maggiolini 1 1 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy 2 Regional Hospital Cosenza, Cosenza, Italy 3 Faculty of Pharmaceutical Sciences, Kan...
10 CitationsSource
#1Rosamaria Lappano (University of Calabria)H-Index: 25
#2Anna Sebastiani (University of Calabria)H-Index: 3
Last. Marcello Maggiolini (University of Calabria)H-Index: 44
view all 10 authors...
The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-promoting benefits of coconut oil intake, including the improvement of the quality of life in breast cancer patients during chemotherapy. As it concerns the potential to hamper tumor growth, LA was shown to elicit inhibitory effects only in colon cancer cells. Here, we provide novel insights regarding the molecular mechanisms through which LA triggers antiproliferative and pro-apoptotic effects in both b...
9 CitationsSource