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Gary D. Steinberg
Johns Hopkins University
CancerPathologyProstateProstate cancerMedicine
16Publications
14H-index
2,381Citations
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Publications 17
Newest
#1Fray F. Marshall (Johns Hopkins University)H-Index: 57
#2Gary D. Steinberg (Johns Hopkins University)H-Index: 14
Last. Alan W. Partin (Johns Hopkins University)H-Index: 99
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A radical nephrectomy typically includes early ligation of the renal vessels, excision of the kidney and perinephric tissue, a regional lymphatenectomy, and an adrenalectomy. More controversial may be excision of supradiaphragmatic caval neoplastic extension and adjacent organ resection. Although survival is low in these unfavorable groups of patients, some patients may benefit from the extensive local resection of tumor, including adrenalectomy, lymphatenectomy, caval resection, and resection o...
6 CitationsSource
#1Anita R. Sgrignoli (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Patrick C. Walsh (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 126
Last. Jonathan I. Epstein (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 127
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AbstractThe role of radical prostatectomy in the management of stage D1 disease is controversial. Although cure is unlikely, some men survive for long intervals apparently free of metastatic disease. For this reason, effective palliation of the local lesion is desirable in men who will live long enough to benefit. In an effort to identify factors that correlated with interval to progression to distant metastases, we studied 113 men with stage D1 disease who underwent radical prostatectomy betwee...
93 CitationsSource
#1Bob S. Carter (Johns Hopkins University)H-Index: 63
#2G. Steven Bova (Johns Hopkins University)H-Index: 49
Last. Patrick C. Walsh (Johns Hopkins University)H-Index: 126
view all 7 authors...
489 CitationsSource
#1Jonathan I. Epstein (Johns Hopkins University)H-Index: 127
#2Galina Pizov (Johns Hopkins University)H-Index: 7
Last. Patrick C. Walsh (Johns Hopkins University)H-Index: 126
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AbstractUsing image cytometry and a video planimetry unit, various deoxyribonucleic acid (DNA) measurements, nuclear size and shape factors, and Gleason grade were correlated with capsular penetration, seminal vesicle invasion and lymph node involvement in 113 radical prostatectomy specimens. Percentage of nondiploid cells was the best DNA measurement and standard deviation of nuclear area was the best size measurement correlating with capsular penetration. However, stepwise regression analysis ...
39 CitationsSource
#1Bob S. Carter (Johns Hopkins University)H-Index: 63
#2Terri L Beaty (Johns Hopkins University)H-Index: 31
Last. Patrick C. Walsh (Johns Hopkins University)H-Index: 126
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Previous studies have demonstrated familial clustering of prostate cancer. To define the nature of this familial aggregation and to assess whether Mendelian inheritance can explain prostate cancer clustering, proportional hazards and segregation analyses were performed on 691 families ascertained through a single prostate cancer proband. The proportional hazards analyses revealed that two factors, early age at onset of disease in the proband and multiple affected family members, were important d...
650 CitationsSource
#1Wayne N. Christensen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
#2Gary D. Steinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
Last. Jonathan I. Epstein (Johns Hopkins University)H-Index: 127
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Previous studies of prostatic duct adenocarcinoma have reported a poor prognosis, but they included few patients treated by radical prostatectomy. The authors studied 15 cases treated with radical prostatectomy to define more completely their pathologic features and determine the clinical outcome in these surgically treated patients. The study included morphometry and DNA image analysis using the CAS-200 system. The most common presentation was urinary outlet obstruction (n = 9), and most patien...
99 CitationsSource
#1Gary D. Steinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
#2Charles B. Higgins (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 96
Last. John T. Isaacs (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 81
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AbstractA rodent bladder cancer model that is induced by intravesical instillation of N-methyl-N-nitrosourea (MNU) was characterized. Cohorts of four to five week old female Fisher 344 rats received four biweekly 1.5mg. doses of intravesical MNU and were sacrificed at various intervals. By week 13 all animals had flat atypia and/or papillary transitional cell tumors, and 67% of the lesions were moderately (grade II) or poorly differentiated (grade III). By week 20, 83% had gross muscle invasive ...
26 CitationsSource
#1Tomohiko Ichikawa (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Jack A. SchalkenH-Index: 60
Last. John T. Isaacs (Johns Hopkins University)H-Index: 81
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To study the relationship between metastatic ability, mutated H-ras expression, and genetic instability, a cloned, nonmetastatic rat prostatic cancer cell line (AT2.1) was transfected with the v-H-ras oncogene. The parental AT2.1 clone, 4 control transfectants (Neo/Only), and 9 v-H-ras transfectants (Neo/Ras) were characterized with regard to their H-ras content by using Southern, Northern, and Western blot analysis and their biological behavior in vivo. Following s.c. inoculation in syngeneic r...
24 CitationsSource
#1Bob S. Carter (Johns Hopkins University)H-Index: 63
#2Gary D. Steinberg (Johns Hopkins University)H-Index: 14
Last. Patrick C. WalshH-Index: 126
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: This chapter describes the application of the genetic epidemiological approach to the study of human prostate cancer. We review the evidence for the familial clustering of prostate cancer and the Mendelian nature of this aggregation. The nature of this clustering is such that the closer genetically a man is to an affected relative and the greater number of relatives affected in a man's family, the greater his risk of prostate cancer. A complex segregation analysis of the 691 prostate cancer fa...
37 Citations
#1Gary D. Steinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
#2Jonathan I. Epstein (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 127
Last. Patrick C. Walsh (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 126
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AbstractThere is no consensus on the proper management of men with stage D1 adenocarcinoma of the prostate. Although cure is unlikely, many men survive for long intervals apparently free of metastatic disease. Thus, effective palliation of the local lesion with low morbidity is desirable. From 1974 to 1987, 120 consecutive men with stage D1 prostate cancer were treated with 3 primary modes of therapy (mean followup 48 months): 1) expectant therapy (35), 2) external beam radiotherapy (21) and 3) ...
140 CitationsSource
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