Patrick J. Collins
Amgen
2Publications
2H-index
5Citations
Publications 2
Newest
Published on Feb 3, 2017in Journal of Biological Chemistry 4.01
Ingrid C. Rulifson5
Estimated H-index: 5
,
Patrick J. Collins2
Estimated H-index: 2
(Amgen)
+ 11 AuthorsCynthia Cam1
Estimated H-index: 1
(Amgen)
Abstract The discovery of brown adipose tissue (BAT) as a key regulator of energy expenditure has sparked interest in identifying novel soluble factors capable of activating inducible BAT (iBAT) to combat obesity. Using a high content cell-based screen, we identified fibroblast growth factor 16 (FGF16) as a potent inducer of several physical and transcriptional characteristics analogous to those of both “classical” BAT and iBAT. Overexpression of Fgf16 in vivo recapitulated several of our in vit...
2 Citations Source Cite
Published on Nov 1, 2017in Pharmacological Research 4.90
Patrick J. Collins2
Estimated H-index: 2
(Amgen),
Christopher M. Hale13
Estimated H-index: 13
(Amgen),
Han Xu1
Estimated H-index: 1
(Amgen)
Abstract Within the short few years since the report of its application in precise genome editing, CRISPR technology has become the method of choice to modify and modulate gene expression in biomedical research and therapeutic development. Subsequently, a variety of research, diagnostic, and therapeutic tools have been developed based upon CRISPR’s mechanism of action. Such tools have helped to deepen the understanding of fundamental biology and broaden the horizon in the search for treatments f...
3 Citations Source Cite
1