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Daijiro Hirai
Organic chemistryChemistryChromatographyActive ingredientAmorphous solid
8Publications
2H-index
9Citations
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Publications 8
Newest
#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Source
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
Source
#1Terushi Ito (University of Toyama)
#2Kotaro Okada (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Source
#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Source
#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Abstract The aim of this study was to demonstrate the usefulness of the time domain nuclear magnetic resonance (TD-NMR) method to characterize the crystalline state of active pharmaceutical ingredients (APIs) containing solid dosage forms. In this study, carbamazepine and indomethacin are used as models for poorly water-soluble APIs. First, we measured the T1 and T2 relaxation behavior of crystalline and amorphous APIs. From the results, we were able to confirm that the T1 relaxation time measur...
Source
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takuya Oishi (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
AbstractObjectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared ta...
4 CitationsSource
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Atsushi KosugiH-Index: 2
Last. Yoshihiro Hayashi (University of Toyama)H-Index: 7
view all 8 authors...
Abstract To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation conditions, and their disintegration time and tensile strength were measured. The present study also investigated various physicochemical properties of the model tablets and disintegrant powders, including wetting time, water absorption ratio, particle size, morphological observation, swelling property, and T 2 relaxation time ( T 2 ). Th...
4 CitationsSource
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takahiro Tsuji (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract In this study, we evaluated the correlation between the response surfaces for the tablet characteristics of placebo and active pharmaceutical ingredient (API)-containing tablets. The quantities of lactose, cornstarch, and microcrystalline cellulose were chosen as the formulation factors. Ten tablet formulations were prepared. The tensile strength (TS) and disintegration time (DT) of tablets were measured as tablet characteristics. The response surfaces for TS and DT were estimated using...
1 CitationsSource
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