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Pratyusa Sahoo
University of Malaya
ChemistryIn vivoInsulinChitosanDrug delivery
2Publications
1H-index
4Citations
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Publications 2
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#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract In designing an oral delivery method for insulin, we previously reported that pH-responsive carboxymethylated kappa -carrageenan-based microparticles protected insulin from acid degradation during transport through the gastrointestinal tract. However, the low surface-to-volume ratio of these microparticles and the presence of only one sulfate group in each kappa -carrageenan subunit for insulin stabilization may lead to a suboptimal delivery efficiency. To improve the delivery efficienc...
4 CitationsSource
1