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Meiling Zhang
Shanghai Jiao Tong University
2Publications
2H-index
25Citations
Publications 2
Newest
Published on Dec 1, 2019in Genome Biology14.03
Meiling Zhang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University),
Changyang Zhou3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
+ 14 AuthorsNing Yao2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
Base editing installs a precise nucleotide change in specific gene loci without causing a double-strand break. Its efficiency in human embryos is generally low, limiting its utility in functional genetic studies. Here, we report that injecting base editors into human cleaving two-cell and four-cell embryos results in much higher (up to 13-fold) homozygotic nucleotide substitution efficiency as opposed to MII oocytes or zygotes. Furthermore, as a proof-of-principle study, a point mutation can be ...
Published on Jun 1, 2018in In Vitro Cellular & Developmental Biology – Animal1.65
Yang Wang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University),
Meiling Zhang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 1 AuthorsYanzhi Du2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
Vitrification of oocytes is closely associated with the lower embryonic developmental potential, which involves the cryopreservation injury occurred during vitrification. It indicates that vitrification may need to be further optimized. Therefore, we studied the effects of resveratrol, an antioxidant, on the developmental potential of vitrified mouse oocytes after in vitro fertilization. After adding a series of concentrations of resveratrol (0, 1, 10, 25, and 50 μM) into vitrification, warming,...
Published on May 1, 2018in Developmental Cell9.19
Xuan Yao7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences),
Meiling Zhang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 13 AuthorsYun Sun9
Estimated H-index: 9
(SJTU: Shanghai Jiao Tong University)
Summary The targeting efficiency of knockin sequences via homologous recombination (HR) is generally low. Here we describe a method we call Tild-CRISPR (targeted integration with linearized dsDNA-CRISPR), a targeting strategy in which a PCR-amplified or precisely enzyme-cut transgene donor with 800-bp homology arms is injected with Cas9 mRNA and single guide RNA into mouse zygotes. Compared with existing targeting strategies, this method achieved much higher knockin efficiency in mouse embryos, ...
Published on Oct 1, 2017in Protein & Cell7.58
Changyang Zhou3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences),
Meiling Zhang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 9 AuthorsWeiping Li7
Estimated H-index: 7
(SJTU: Shanghai Jiao Tong University)
Published on Jun 1, 2016in Cell Research17.85
Cuiqing Zhong5
Estimated H-index: 5
,
Meiling Zhang1
Estimated H-index: 1
+ 7 AuthorsJinsong Li27
Estimated H-index: 27
Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus
Published on Jan 1, 2016in Reproduction, Fertility and Development1.72
Qiaoli Zhang1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Dong Liu1
Estimated H-index: 1
(Tianjin Medical University)
+ 4 AuthorsZi-Jiang Chen36
Estimated H-index: 36
(SDU: Shandong University)
Brain-derived neurotrophic factor (BDNF) is expressed extensively in the mammalian female reproductive system and has been implicated in the development of follicles and oocytes. However, BDNF expression patterns in the ovary and its effects on oocyte maturation and embryonic development in polycystic ovary syndrome (PCOS) have not been established. In the present study, we established a PCOS model by treating the rats with insulin and human chorionic gonadotropin (hCG). Rats treated with insuli...
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