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Antonio L. Dans
University of the Philippines
56Publications
25H-index
6,773Citations
Publications 56
Newest
#1Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
#2Philip Joseph (Population Health Research Institute)H-Index: 17
Last.Gilles Dagenais (Laval University)H-Index: 31
view all 39 authors...
Summary Background Global estimates of the effect of common modifiable risk factors on cardiovascular disease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using similar methods to prospectively measure the effect of modifiable risk factors on cardiovascular disease and mortality across 21 countries (spanning five continents) grouped by different economic levels. M...
4 CitationsSource
#1Paul Moayyedi (Population Health Research Institute)H-Index: 3
#2John W. Eikelboom (Population Health Research Institute)H-Index: 93
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 50 authors...
Background & Aims Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. Methods We performed a 3 × 2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease randomly assigned to groups given p...
9 CitationsSource
#1Perry Hystad (OSU: Oregon State University)H-Index: 14
#2MyLinh Duong (Population Health Research Institute)H-Index: 16
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 31 authors...
Background: Household air pollution (HAP) from solid fuel use for cooking affects 2.5 billion individuals globally and may contribute substantially to disease burden. However, few prospective studi...
1 CitationsSource
#1Prem Pais (St. John's University)H-Index: 46
#2Hyejung Jung (Population Health Research Institute)H-Index: 14
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 9 authors...
Background and designThere are limited data on the effects of blood pressure and cholesterol lowering in Asians at intermediate risk and no cardiovascular disease. We report an analysis of the effe...
2 CitationsSource
#1Jackie BoschH-Index: 45
#2Martin O'DonnellH-Index: 54
view all 21 authors...
Objective To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk. Methods The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 × 2 factorial design. Participants without known cardiovascular disease or need for treatment were randomized to candesartan (16 mg) plus hydrochlorothiazide...
4 CitationsSource
#1Andrew Mente (McMaster University)H-Index: 32
#2Martin O'Donnell (McMaster University)H-Index: 54
Last.Salim Yusuf Mb Bs DPhil Frcpc (McMaster University)H-Index: 214
view all 32 authors...
Summary Background WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovascular disease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) without data relating low sodium intake to reduced cardiovascular events from randomised trials or observational studies. We investigated the associations between community-level mean sodium and p...
45 CitationsSource
#1Peter Langhorne (Glas.: University of Glasgow)H-Index: 70
#2Martin O'Donnell (National University of Ireland, Galway)H-Index: 54
Last.K. McBurnieH-Index: 1
view all 373 authors...
Summary Background Stroke disproportionately affects people in low-income and middle-income countries. Although improvements in stroke care and outcomes have been reported in high-income countries, little is known about practice and outcomes in low and middle-income countries. We aimed to compare patterns of care available and their association with patient outcomes across countries at different economic levels. Methods We studied the patterns and effect of practice variations (ie, treatments us...
14 CitationsSource
#1Jackie Bosch (McMaster University)H-Index: 45
#2Eva Lonn (McMaster University)H-Index: 65
Last.Salim Yusuf Mb Bs DPhil Frcpc (McMaster University)H-Index: 214
view all 9 authors...
Background: Most (75%) strokes are first strokes, and primary prevention is crucial for reducing the global burden of stroke The role of fixed-dose antihypertensive therapy and statin drugs for pri...
Source
BackgroundWe evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. MethodsIn this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or m...
418 CitationsSource
#1Jackie Bosch (McMaster University)H-Index: 45
#2John W. Eikelboom (Population Health Research Institute)H-Index: 93
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 58 authors...
Abstract Background Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy. Methods C ardiovascular O utco m es for P eople Using A ntic...
43 CitationsSource
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