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Antonio L. Dans
University of the Philippines
52Publications
22H-index
5,842Citations
Publications 52
Newest
Published on May 1, 2019in Gastroenterology 19.23
Paul Moayyedi1
Estimated H-index: 1
(Population Health Research Institute),
John A. Eikelboom (Population Health Research Institute)+ 47 AuthorsKelley Branch1
Estimated H-index: 1
(University of Washington Medical Center)
Abstract Background & Aims Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. Methods We performed a 3x2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease randomly assigned to groups ...
Published on May 1, 2019in Environmental Health Perspectives 8.05
Perry Hystad22
Estimated H-index: 22
(OSU: Oregon State University),
Perry Hystad6
Estimated H-index: 6
(OSU: Oregon State University)
+ 29 AuthorsIgbal Azam (Aga Khan University)
Background: Household air pollution (HAP) from solid fuel use for cooking affects 2.5 billion individuals globally and may contribute substantially to disease burden. However, few prospective studi...
Published on May 1, 2019in European Journal of Preventive Cardiology 5.64
Prem Pais42
Estimated H-index: 42
(St. John's University),
Hyejung Jung14
Estimated H-index: 14
(Population Health Research Institute)
+ 6 AuthorsSalim Yusuf Mb Bs DPhil Frcpc209
Estimated H-index: 209
(Population Health Research Institute)
Background and designThere are limited data on the effects of blood pressure and cholesterol lowering in Asians at intermediate risk and no cardiovascular disease. We report an analysis of the effects of blood pressure and cholesterol lowering in Asians enrolled in the Heart Outcomes Prevention Evaluation 3 (HOPE 3) trial.MethodsWe randomly assigned 6241 Asians and 6464 non-Asians at intermediate risk without cardiovascular disease to candesartan 16 mg/hydrochlorothiazide 12.5 mg or placebo and ...
Published on Mar 26, 2019in Neurology 8.69
Jackie Bosch43
Estimated H-index: 43
,
Martin O'Donnell50
Estimated H-index: 50
+ 18 AuthorsAlvaro Avezum70
Estimated H-index: 70
Objective To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk. Methods The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 × 2 factorial design. Participants without known cardiovascular disease or need for treatment were randomized to candesartan (16 mg) plus hydrochlorothiazide...
Published on Aug 1, 2018in The Lancet 59.10
Andrew Mente30
Estimated H-index: 30
(McMaster University),
Martin O'Donnell50
Estimated H-index: 50
(McMaster University)
+ 29 AuthorsRafael Diaz71
Estimated H-index: 71
Summary Background WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovascular disease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) without data relating low sodium intake to reduced cardiovascular events from randomised trials or observational studies. We investigated the associations between community-level mean sodium and p...
Published on May 1, 2018in The Lancet 59.10
Peter Langhorne65
Estimated H-index: 65
(Glas.: University of Glasgow),
Martin O'Donnell50
Estimated H-index: 50
(National University of Ireland, Galway)
+ 370 AuthorsPatricio López-Jaramillo42
Estimated H-index: 42
Summary Background Stroke disproportionately affects people in low-income and middle-income countries. Although improvements in stroke care and outcomes have been reported in high-income countries, little is known about practice and outcomes in low and middle-income countries. We aimed to compare patterns of care available and their association with patient outcomes across countries at different economic levels. Methods We studied the patterns and effect of practice variations (ie, treatments us...
Published on Jan 22, 2018in Stroke 6.05
Jackie Bosch43
Estimated H-index: 43
(McMaster University),
Eva Lonn64
Estimated H-index: 64
(McMaster University)
+ 6 AuthorsSalim Yusuf Mb Bs DPhil Frcpc209
Estimated H-index: 209
(McMaster University)
Background: Most (75%) strokes are first strokes, and primary prevention is crucial for reducing the global burden of stroke The role of fixed-dose antihypertensive therapy and statin drugs for primary stroke prevention has not been adequately defined. Methods: Using a 2x2 factorial design, 12,705 participants from 21 countries with an intermediate risk of cardiovascular disease but without overt vascular disease were randomized to fixed-dose candesartan 16 mg plus hydrochlorothiazide (HCTZ) 12....
Published on Oct 5, 2017in The New England Journal of Medicine 70.67
John W. Eikelboom89
Estimated H-index: 89
,
Stuart J. Connolly89
Estimated H-index: 89
+ 46 AuthorsSonia S. Anand74
Estimated H-index: 74
BackgroundWe evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. MethodsIn this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or m...
Published on Aug 1, 2017in Canadian Journal of Cardiology 5.59
Jackie Bosch43
Estimated H-index: 43
(McMaster University),
John W. Eikelboom89
Estimated H-index: 89
(Population Health Research Institute)
+ 55 AuthorsA. M. W. Alings31
Estimated H-index: 31
Abstract Background Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy. Methods C ardiovascular O utco m es for P eople Using A ntic...
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