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Tony R. Hazbun
Purdue University
39Publications
17H-index
1,209Citations
Publications 39
Newest
#1Jack Guinan (MWU: Midwestern University)H-Index: 1
#2Shaohua Wang (Wake Forest University)H-Index: 3
Last.Shankar Thangamani (MWU: Midwestern University)H-Index: 12
view all 5 authors...
Candida albicans is the fourth most common cause of systemic nosocomial infections, posing a significant risk in immunocompromised individuals. As the majority of systemic C. albicans infections stem from endogenous gastrointestinal (GI) colonization, understanding the mechanisms associated with GI colonization is essential in the development of novel methods to prevent C. albicans-related mortality. In this study, we investigated the role of microbial-derived short-chain fatty acids (SCFAs) inc...
#1Chen Chen (Purdue University)H-Index: 3
#2Dabao Zhang (Purdue University)H-Index: 12
Last.Min Zhang (Purdue University)H-Index: 17
view all 4 authors...
Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by c...
#1Hassan E. Eldesouky (Purdue University)H-Index: 3
#2Ehab A. Salama (Purdue University)
Last.Mohamed N. Seleem (Purdue University)H-Index: 21
view all 6 authors...
The limited number of systemic antifungals and the emergence of azole-resistant Candida species constitute a growing challenge to human medicine. Combinatorial drug therapy represents an appealing approach to enhance the activity of, or restore the susceptibility to current antifungals. Here, we evaluated the fluconazole chemosensitization activity of the Pharmakon 1600 drug library against azole-resistant Candida albicans. We identified 33 non-antifungal drugs that were able to restore suscepti...
#1Haroon Mohammad (Purdue University)H-Index: 12
#2Nehal H. ElghazawyH-Index: 2
Last.Mohamed N. Seleem (Purdue University)H-Index: 21
view all 9 authors...
Globally, invasive fungal infections pose a significant challenge to modern human medicine due to the limited number of antifungal drugs and the rise in resistance to current antifungal agents. A vast majority of invasive fungal infections are caused by species of Candida, Cryptococcus, and Aspergillus. Novel antifungal molecules consisting of unexploited chemical scaffolds with a unique mechanism are a pressing need. The present study identifies a dibromoquinoline compound (4b) with broad-spect...
#1Christopher J. Buehl (MSU: Michigan State University)H-Index: 3
#2Xiexiong Deng (MSU: Michigan State University)H-Index: 3
Last.Min Hao Kuo (MSU: Michigan State University)H-Index: 12
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Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugoshin 1, be recruited to the centromeres and the neighboring pericentric regions. Concerted actions integrating proteins at centromeres and pericentromeres create highly specific Shugo...
#1Prashant K. Mishra (NIH: National Institutes of Health)H-Index: 7
#2Kriti Shrestha Thapa (Purdue University)H-Index: 2
Last.Munira A. Basrai (NIH: National Institutes of Health)H-Index: 18
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ABSTRACTShugoshin is an evolutionarily conserved protein, which is involved in tension sensing on mitotic chromosomes, kinetochore biorientation, and protection of centromeric (CEN) cohesin for faithful chromosome segregation. Interaction of the C-terminus of Sgo1 with phosphorylated histone H2A regulates its association with CEN and pericentromeric (peri-CEN) chromatin, whereas mutations in histone H3 selectively compromise the association of Sgo1 with peri-CEN but not CEN chromatin. Given that...
#1Fiona M. Thomas (Purdue University)H-Index: 1
#2Kourtney M. Goode (Purdue University)H-Index: 2
Last.V. Jo Davisson (Purdue University)H-Index: 26
view all 7 authors...
Compounds that modulate the heat shock protein (HSP) network have potential in a broad range of research applications and diseases. A yeast-based liquid culture assay that measured time-dependent turbidity enabled the high-throughput screening of different Saccharomyces cerevisae strains to identify HSP modulators with unique molecular mechanisms. A focused set of four strains, with differing sensitivities to Hsp90 inhibitors, was used to screen a compound library of 3680 compounds. Computed tur...
#1Kourtney M. Goode (Purdue University)H-Index: 2
#2Dino P. Petrov (Purdue University)H-Index: 2
Last.Tony R. Hazbun (Purdue University)H-Index: 17
view all 8 authors...
Abstract Background Inhibition of Hsp90 is desirable due to potential downregulation of oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C-terminal domain (CTD) inhibitors are a promising class because they do not induce a heat shock response. Here we present a new structural class of CTD binding molecules with a unique allosteric inhibition mechanism. Methods A hit molecule, NSC145366, and structurally similar probes were assessed for inhibition of Hsp90 ac...
#1Shankar Thangamani (Purdue University)H-Index: 12
#2Matthew Maland (UCLA: University of California, Los Angeles)H-Index: 1
Last.Mohamed N. Seleem (Purdue University)H-Index: 21
view all 8 authors...
Current antifungal therapies have limited effectiveness in treating invasive fungal infections. Furthermore, the development of new antifungal is currently unable to keep pace with the urgent demand for safe and effective new drugs. Auranofin, an FDA-approved drug for the treatment of rheumatoid arthritis, inhibits growth of a diverse array of clinical isolates of fungi and represents a new antifungal agent with a previously unexploited mechanism of action. In addition to auranofin’s potent anti...
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