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Tony R. Hazbun
Purdue University
Molecular biologyKinetochoreSaccharomyces cerevisiaeGeneticsBiology
42Publications
18H-index
1,264Citations
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Publications 43
Newest
#1Hassan E. Eldesouky (Purdue University)H-Index: 4
#2Ehab A. Salama (Purdue University)
Last. Mohamed N. Seleem (Purdue University)H-Index: 22
view all 6 authors...
The limited number of antifungals and the rising frequency of azole-resistant Candida species are growing challenges to human medicine. Drug repurposing signifies an appealing approach to enhance the activity of current antifungal drugs. Here, we evaluated the ability of Pharmakon 1600 drug library to sensitize an azole-resistant Candida albicans to the effect of fluconazole. The primary screen revealed 44 non-antifungal hits were able to act synergistically with fluconazole against the test str...
Source
#1Hassan E. Eldesouky (Purdue University)H-Index: 4
#2Ehab A. Salama (Purdue University)
Last. Mohamed N. Seleem (Purdue University)H-Index: 22
view all 5 authors...
Azole antifungals are vital therapeutic options for treating invasive mycotic infections. However, the emergence of azole-resistant isolates combined with limited therapeutic options presents a growing challenge in medical mycology. To address this issue, we utilized microdilution checkerboard assays to evaluate nine stilbene compounds for their ability to interact synergistically with azole drugs, particularly against azole-resistant fungal isolates. Ospemifene displayed the most potent azole c...
Source
#1Sonia Villa (MWU: Midwestern University)
#2Mohammad Hamideh (MWU: Midwestern University)
Last. Shankar Thangamani (MWU: Midwestern University)H-Index: 13
view all 8 authors...
Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct ...
Source
#1Haroon Mohammad (Purdue University)H-Index: 15
#2Hassan E. Eldesouky (Purdue University)H-Index: 4
Last. Mohamed N. Seleem (Purdue University)H-Index: 22
view all 5 authors...
Candida species are a leading source of healthcare infections globally. The limited number of antifungal drugs combined with the isolation of Candida species, namely C. albicans and C. auris, exhibiting resistance to current antifungals necessitates the development of new therapeutics. The present study tested 85 synthetic phenylthiazole small molecules for antifungal activity against drug-resistant C. albicans. Compound 1 emerged as the most potent molecule, inhibiting growth of C. albicans and...
3 CitationsSource
#1Hassan E. Eldesouky (Purdue University)H-Index: 4
#2Ehab A. Salama (Purdue University)
Last. Mohamed N. Seleem (Purdue University)H-Index: 22
view all 6 authors...
The limited number of systemic antifungals and the emergence of azole-resistant Candida species constitute a growing challenge to human medicine. Combinatorial drug therapy represents an appealing approach to enhance the activity of, or restore the susceptibility to current antifungals. Here, we evaluated the fluconazole chemosensitization activity of the Pharmakon 1600 drug library against azole-resistant Candida albicans. We identified 33 non-antifungal drugs that were able to restore suscepti...
Source
#1Jack Guinan (MWU: Midwestern University)H-Index: 2
#2Shaohua Wang (Wake Forest University)H-Index: 5
Last. Shankar Thangamani (MWU: Midwestern University)H-Index: 13
view all 5 authors...
Candida albicans is the fourth most common cause of systemic nosocomial infections, posing a significant risk in immunocompromised individuals. As the majority of systemic C. albicans infections stem from endogenous gastrointestinal (GI) colonization, understanding the mechanisms associated with GI colonization is essential in the development of novel methods to prevent C. albicans-related mortality. In this study, we investigated the role of microbial-derived short-chain fatty acids (SCFAs) inc...
1 CitationsSource
#1Chen Chen (Purdue University)H-Index: 7
#2Dabao Zhang (Purdue University)H-Index: 12
Last. Min Zhang (Purdue University)H-Index: 17
view all 4 authors...
Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by c...
Source
#1Haroon Mohammad (Purdue University)H-Index: 15
#2Nehal H. ElghazawyH-Index: 2
Last. Mohamed N. Seleem (Purdue University)H-Index: 22
view all 9 authors...
Globally, invasive fungal infections pose a significant challenge to modern human medicine due to the limited number of antifungal drugs and the rise in resistance to current antifungal agents. A vast majority of invasive fungal infections are caused by species of Candida, Cryptococcus, and Aspergillus. Novel antifungal molecules consisting of unexploited chemical scaffolds with a unique mechanism are a pressing need. The present study identifies a dibromoquinoline compound (4b) with broad-spect...
6 CitationsSource
#1Christopher J. Buehl (MSU: Michigan State University)H-Index: 3
#2Xiexiong Deng (MSU: Michigan State University)H-Index: 3
Last. Min Hao Kuo (MSU: Michigan State University)H-Index: 12
view all 6 authors...
Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugoshin 1, be recruited to the centromeres and the neighboring pericentric regions. Concerted actions integrating proteins at centromeres and pericentromeres create highly specific Shugo...
3 CitationsSource
#1Prashant K. Mishra (NIH: National Institutes of Health)H-Index: 7
#2Kriti Shrestha Thapa (Purdue University)H-Index: 2
Last. Munira A. Basrai (NIH: National Institutes of Health)H-Index: 19
view all 6 authors...
ABSTRACTShugoshin is an evolutionarily conserved protein, which is involved in tension sensing on mitotic chromosomes, kinetochore biorientation, and protection of centromeric (CEN) cohesin for faithful chromosome segregation. Interaction of the C-terminus of Sgo1 with phosphorylated histone H2A regulates its association with CEN and pericentromeric (peri-CEN) chromatin, whereas mutations in histone H3 selectively compromise the association of Sgo1 with peri-CEN but not CEN chromatin. Given that...
7 CitationsSource
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