Takuya Oishi
University of Toyama
Hausner ratioChemistryMicrocrystalline celluloseChromatographyActive ingredient
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Publications 3
#1Takuya Oishi (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Abstract Our aim was to understand better the causal relationships between material attributes (MAs), process parameters (PPs), and critical quality attributes (CQAs) using an originally created large dataset and regularized linear regression models. In this study, we focused on the following three points: (1) creation of a dataset comprising several tablet production methods, (2) the influence of interaction terms of MAs and/or PPs, and (3) comparison of regularized linear regression models wit...
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takuya Oishi (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
AbstractObjectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared ta...
4 CitationsSource
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takahiro Tsuji (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract In this study, we evaluated the correlation between the response surfaces for the tablet characteristics of placebo and active pharmaceutical ingredient (API)-containing tablets. The quantities of lactose, cornstarch, and microcrystalline cellulose were chosen as the formulation factors. Ten tablet formulations were prepared. The tensile strength (TS) and disintegration time (DT) of tablets were measured as tablet characteristics. The response surfaces for TS and DT were estimated using...
1 CitationsSource