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Leena Mathew
Temple University
AntigenAntibodyHuman leukocyte antigenImmunologyBiology
3Publications
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Publications 3
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#1Steven S. Geier (TU: Temple University)H-Index: 2
#2Leena Mathew (TU: Temple University)
Last. Olga Timofeeva (TU: Temple University)H-Index: 17
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Aim The accuracy of HLA antibody testing is very important for entering UNOS Unacceptable donor antigens, evaluating organ offers by virtual and prospective crossmatch, and evaluating donor specific antibodies (DSAs) pre and post transplant. It is known that Single Antigen Beads (SAB) often have problems with false positive reactions, when the manufacturing process results in 3–5% denatured HLA determinants on every bead, exposing cryptic, non HLA antigens. This case study demonstrates that SAB ...
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#1Steven S. Geier (TU: Temple University)H-Index: 2
#2Josheph Rudic (TU: Temple University)
Last. Olga Timofeeva (TU: Temple University)H-Index: 17
view all 9 authors...
Aim The accuracy of HLA antibody testing is very important for entering UNOS Unacceptable donor antigens, evaluating organ offers by virtual and prospective crossmatch, and evaluating donor specific antibodies (DSAs) pre and post transplant. It is known that the Single Antigen Bead (SAB) assay can have HLA antibody false positives reactions, due to the exposure of cryptic, non HLA antigens, during the manufacturing process. This study was to determine the SAB false positive rate in our testing a...
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