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Encarnita Mariotti-Ferrandiz
University of Paris
14Publications
5H-index
100Citations
Publications 14
Newest
#1Darawan Rinchai (Qatar Airways)H-Index: 13
Last.Damien Chaussabel (Qatar Airways)H-Index: 46
view all 10 authors...
Availability of large collections of public omics data creates a wide range of hands-on training opportunities for biomedical investigators. The organization and outcome of a workshop focusing on implementation of modular repertoire analysis and visualization approaches is described here. This analytic strategy has been developed specifically for mining of blood transcriptome data. Workshop participants conducted modular repertoire analyses of public blood transcriptome datasets generated from p...
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#1Paul-Gydeon Ritvo (University of Paris)H-Index: 2
#2Ahmed Saadawi (University of Paris)H-Index: 1
Last.David Klatzmann (University of Paris)H-Index: 63
view all 11 authors...
T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated for Tfr cells. Here, we used high-throughput T cell receptor (TCR) sequencing to analyze the repertoires of Tfh and Tfr cells, at homeostasis and after imm...
7 CitationsSource
#1Roberta LorenzonH-Index: 3
#2Encarnita Mariotti-Ferrandiz (University of Paris)H-Index: 5
Last.David KlatzmannH-Index: 63
view all 29 authors...
Introduction Autoimmune and autoinflammatory diseases (AIDs) represent a socioeconomic burden as the second cause of chronic illness in Western countries. In this context, the TRANSIMMUNOM clinical protocol is designed to revisit the nosology of AIDs by combining basic, clinical and information sciences. Based on classical and systems biology analyses, it aims to uncover important phenotypes that cut across diagnostic groups so as to discover biomarkers and identify novel therapeutic targets. Me...
1 CitationsSource
#1Roberta Lorenzon (University of Paris)H-Index: 3
#2Iannis Drakos (University of Paris)H-Index: 1
Last.Encarnita Mariotti-Ferrandiz (University of Paris)H-Index: 5
view all 25 authors...
Objectives: Autoimmune and inflammatory diseases (AIDs) form a continuum of autoimmune and inflammatory diseases, yet AIDs' nosology is based on syndromic classification. The TRANSIMMUNOM trial (NCT02466217) was designed to re-evaluate AIDs nosology through clinic-biological and multi-omics investigations of patients with one of 19 selected AIDs. To allow cross-analyses of clinic-biological data together with omics data, we needed to integrate clinical data in a harmonized database. Materials an...
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#1Wahiba Chaara (University of Paris)H-Index: 10
#2Ariadna Gonzalez-Tort (University of Paris)H-Index: 1
Last.Adrien Six (University of Paris)H-Index: 25
view all 6 authors...
High-throughput sequencing (HTS) has the potential to decipher the diversity of T cell repertoires and their dynamics during immune responses. Applied to T cell subsets such as T effector and T regulatory cells, it should help identify novel biomarkers of diseases. However, given the extreme diversity of TCR repertoires, understanding how the sequencing conditions, including cell numbers, biological and technical sampling and sequencing depth, impact the experimental outcome is critical to prope...
1 CitationsSource
#1Pierre Ellul (University of Paris)H-Index: 3
#2Encarnita Mariotti-Ferrandiz (University of Paris)H-Index: 5
Last.David Klatzmann (University of Paris)H-Index: 63
view all 4 authors...
There is growing evidence that inflammation plays a role in major depressive disorder (MDD). As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD. However, neither a qualitative nor a quantitative defect of Tregs has been ascertained, and no causality direction between inflammation and depression has been established. Here, after reviewing the evidence supporting a relation between Treg insufficiency and MDD, we conclude that a ...
2 CitationsSource
#1Wahiba Chaara (University of Paris)H-Index: 10
#2Encarnita Mariotti-Ferrandiz (University of Paris)H-Index: 5
Last.David Klatzmann (University of Paris)H-Index: 63
view all 6 authors...
High-throughput sequencing (HTS) has the potential to decipher the diversity of T cell repertoires and their dynamics during immune responses. Applied to T cell subsets such as T effector and T regulatory cells, it should help identify novel biomarkers of diseases. However, given the extreme diversity of TCR repertoires, understanding how the sequencing conditions, including cell numbers, biological and technical sampling and sequencing depth, impact the experimental outcome is critical to prope...
Source
#1Paul-Gydeon Ritvo (University of Paris)H-Index: 2
#2Wahiba Chaara (University of Paris)H-Index: 10
Last.David Klatzmann (University of Paris)H-Index: 63
view all 7 authors...
T follicular helper (Tfh) and regulatory (Tfr) cells regulate B cell activation and ultimately antibody production. While concordant results show that Tfh cells are specific for the immunizing antigens, limited and even controversial results have been reported regarding the specificity of Tfr cells. Here we used high-throughput T cell receptor (TCR) sequencing to address this issue. We observed that although the Tfh- and Tfr-cell repertoires are less diverse than those of effector (Teff) and reg...
1 CitationsSource
#1Paul-Gydeon Ritvo (University of Paris)H-Index: 2
#2Guillame Churlaud (University of Paris)H-Index: 1
Last.David Klatzmann (University of Paris)H-Index: 63
view all 8 authors...
Follicular regulatory T (T fr ) cells from lymph node germinal centers control follicular helper T (T fh ) cell–dependent B cell activation. These scarce cells, often described and purified as CD25 + cells, are thought to be derived from thymic regulatory T (T reg ) cells. However, we observed that mouse T fr cells do not respond to interleukin-2 (IL-2), unlike T reg cells. Stringent immunophenotyping based on B cell lymphoma 6 (Bcl6), programmed cell death protein 1 (PD-1), and CXCR5 expression...
27 CitationsSource
#1Ana Raquel Maceiras (IGC: Instituto Gulbenkian de Ciência)H-Index: 4
#2S. Almeida (IGC: Instituto Gulbenkian de Ciência)H-Index: 6
Last.Luis Graca (IGC: Instituto Gulbenkian de Ciência)H-Index: 31
view all 10 authors...
T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear. Here the authors show that T cells with distinct antigen specificity spectra are recruited to the germinal centre to establish these two populations.
40 CitationsSource
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