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Tadakazu Tokumura
International University of Health and Welfare
High-performance liquid chromatographyHelicobacter pyloriOral administrationMetronidazoleStomach
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#1Mai KuboderaH-Index: 1
#2Tadakazu Tokumura (International University of Health and Welfare)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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Abstract In the eradication therapy of Helicobacter pylori changes of antibiotics as these concentrations or amount in the stomach after oral administration were not clear. A simple and accurate method for determining the concentration of metronidazole (MTZ) in homogenate of rat stomach was developed in order to obtain basic data to design a pharmaceutical preparation having targeting ability to the surface of gastric-mucosa. This method included a deproteinization process by methanol, separatio...
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