Yan Wang
Shanghai Jiao Tong University
VasodilationProtein kinase CEndotheliumVascular smooth muscleProtein kinase A
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Publications 3
#1Yan Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Quanhong Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 10
Last. Ai-Zhong Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
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Background and Purpose Exaggerated hypotension following administration of propofol is strongly predicted in patients with hypertension. Increased PKCs play a crucial role in regulating vascular tone. We studied whether propofol induces vasodilation by inhibiting increased PKC activity in spontaneously hypertensive rats (SHRs) and, if so, whether contractile Ca2+ sensitization pathways and filamentous–globular (F/G) actin dynamics were involved. Experimental Approach Rings of thoracic aorta, den...
1 CitationsSource
#1Huixuan ZhouH-Index: 2
#2Yan WangH-Index: 2
Last. Li WangH-Index: 4
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Background/Aims: Phorbol myristate acetate (PMA) exerts a pleiotropic effect on the growth and differentiation of various cells. Protein kinase Cs (PKCs) plays a central role in mediating the effects of PMA on cells. The present study investigated whether the down-regulation of protein kinase C-e (PKC-e) is involved in the inhibition of vascular smooth muscle cell (VSMC) proliferation caused by prolonged PMA incubation. Methods: Using cell counting, Cell Counting Kit-8 (CCK-8) and EdU incorporat...
3 CitationsSource
#1Yan WangH-Index: 2
#2Huixuan ZhouH-Index: 2
Last. Li WangH-Index: 4
view all 6 authors...
Abstract Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing the PKC-mediated nitric oxide synthesis in endothelium and/or inhibiting the PKC-regulated Ca sensitivity in vascular smooth muscle (VSM). Propofol (1-100 μM) induced greater relaxation in endothelium-int...
11 CitationsSource