Zhuchi Tu
Jinan University
12Publications
7H-index
239Citations
Publications 12
Newest
Published on Feb 15, 2019in Cell Research 15.39
Weili Yang9
Estimated H-index: 9
,
Yunbo Liu + 12 AuthorsZhengyi Yang
Source Cite
Published on Feb 15, 2019in Human Molecular Genetics 4.90
Zhuchi Tu7
Estimated H-index: 7
(Jinan University),
Hui Zhao2
Estimated H-index: 2
(Chinese Academy of Sciences)
+ 14 AuthorsYingqi Lin (Jinan University)
Source Cite
Sen Yan10
Estimated H-index: 10
(Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Abstract Aging-related brain diseases consist of a number of important neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases, all of which have become more prevalent as the life expectancy of humans is prolonged. Age-dependent brain disorders are associated with both environmental insults and genetic mutations. For those brain disorders that are inherited, gene editing is an important tool for establishing animal models to investigate the pathogenesis of dise...
3 Citations Source Cite
Published on May 1, 2018in Cell 31.40
Sen Yan10
Estimated H-index: 10
(Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
18 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Zhuchi Tu7
Estimated H-index: 7
,
Weili Yang9
Estimated H-index: 9
+ 10 AuthorsSu Yang8
Estimated H-index: 8
18 Citations Source Cite
Published on Oct 1, 2017in Cell Research 15.39
Hui Zhao2
Estimated H-index: 2
,
Zhuchi Tu7
Estimated H-index: 7
+ 12 AuthorsRui Tian1
Estimated H-index: 1
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3 -deficient non-human primate
18 Citations Source Cite
Published on Sep 1, 2017in Cell Stem Cell 23.29
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
1 Citations Source Cite
Published on Apr 28, 2016in Frontiers in Molecular Neuroscience 3.90
Weili Yang9
Estimated H-index: 9
(Chinese Academy of Sciences),
Zhuchi Tu7
Estimated H-index: 7
(Chinese Academy of Sciences)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Chinese Academy of Sciences)
CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative ...
18 Citations Source Cite
Published on May 27, 2015in The Journal of Neuroscience 5.97
Weili Yang9
Estimated H-index: 9
(Chinese Academy of Sciences),
Guohao Wang5
Estimated H-index: 5
(Chinese Academy of Sciences)
+ 9 AuthorsXintian Hu15
Estimated H-index: 15
(Kunming Institute of Zoology)
Parkinson's disease (PD) is an age-dependent neurodegenerative disease that often occurs in those over age 60. Although rodents and small animals have been used widely to model PD and investigate its pathology, their short life span makes it difficult to assess the aging-related pathology that is likely to occur in PD patient brains. Here, we used brain tissues from rhesus monkeys at 2–3, 7–8, and >15 years of age to examine the expression of Parkin, PINK1, and α-synuclein, which are known to ca...
24 Citations Source Cite
Published on Dec 1, 2015in Molecular Neurodegeneration 6.43
Zhuchi Tu7
Estimated H-index: 7
(Chinese Academy of Sciences),
Weili Yang9
Estimated H-index: 9
(Chinese Academy of Sciences)
+ 2 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Chinese Academy of Sciences)
Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals are more like humans than rodents, they make good models to identify the important pathological events that may be seen in humans but not in small animals; large animals are also very important for validating effective treatments or confirming therapeutic targets. Due to the lack of embryonic stem cell lines from large animals, it has bee...
45 Citations Source Cite
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