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Zhuchi Tu
Jinan University
12Publications
7H-index
255Citations
Publications 12
Newest
#1Hui Zhao (CAS: Chinese Academy of Sciences)H-Index: 2
#2Qiqi Wang (CAS: Chinese Academy of Sciences)
Last.Xiao-Jiang Li (Emory University)H-Index: 61
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Despite the substantial progress made in identifying genetic defects in autism spectrum disorder (ASD), the etiology for majority of ASD individuals remains elusive. Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy in human, has long been considered a risk factor to contribute to ASD susceptibility in offspring from epidemiological studies in humans. The similar exposures in murine models have provided tentative evidence to support the finding f...
#1Weili Yang (JNU: Jinan University)H-Index: 9
#2Yunbo Liu (Peking Union Medical College)H-Index: 1
Last.Zhengyi Yang (CAS: Chinese Academy of Sciences)H-Index: 14
view all 15 authors...
#1Zhuchi Tu (JNU: Jinan University)H-Index: 7
#2Hui Zhao (CAS: Chinese Academy of Sciences)H-Index: 2
Last.Yingqi Lin (JNU: Jinan University)
view all 17 authors...
#1Sen Yan (JNU: Jinan University)H-Index: 11
#2Zhuchi Tu (JNU: Jinan University)H-Index: 7
Last.Chengdan Lai (Guangzhou Institutes of Biomedicine and Health)H-Index: 4
view all 21 authors...
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
#1Sen Yan (JNU: Jinan University)H-Index: 11
#2Zhuchi Tu (JNU: Jinan University)H-Index: 7
Last.Xiao-Jiang Li (Emory University)H-Index: 61
view all 4 authors...
Abstract Aging-related brain diseases consist of a number of important neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases, all of which have become more prevalent as the life expectancy of humans is prolonged. Age-dependent brain disorders are associated with both environmental insults and genetic mutations. For those brain disorders that are inherited, gene editing is an important tool for establishing animal models to investigate the pathogenesis of dise...
#1Hui ZhaoH-Index: 2
#2Zhuchi TuH-Index: 7
Last.Rui TianH-Index: 2
view all 15 authors...
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3 -deficient non-human primate
#1Xiao-Jiang Li (Emory University)H-Index: 61
#2Zhuchi Tu (JNU: Jinan University)H-Index: 7
Last.Li Shihua (Emory University)H-Index: 76
view all 4 authors...
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
#1Weili Yang (CAS: Chinese Academy of Sciences)H-Index: 9
#2Zhuchi Tu (CAS: Chinese Academy of Sciences)H-Index: 7
Last.Xiao-Jiang Li (CAS: Chinese Academy of Sciences)H-Index: 61
view all 4 authors...
CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative ...
#1Zhuchi Tu (CAS: Chinese Academy of Sciences)H-Index: 7
#2Weili Yang (CAS: Chinese Academy of Sciences)H-Index: 9
Last.Xiao-Jiang Li (CAS: Chinese Academy of Sciences)H-Index: 61
view all 5 authors...
Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals are more like humans than rodents, they make good models to identify the important pathological events that may be seen in humans but not in small animals; large animals are also very important for validating effective treatments or confirming therapeutic targets. Due to the lack of embryonic stem cell lines from large animals, it has bee...
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