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Zhuchi Tu
Jinan University
12Publications
7H-index
255Citations
Publications 12
Newest
Published on Apr 1, 2019in Cell Research17.85
Weili Yang9
Estimated H-index: 9
(JNU: Jinan University),
Yunbo Liu1
Estimated H-index: 1
(Peking Union Medical College)
+ 12 AuthorsZhengyi Yang14
Estimated H-index: 14
(CAS: Chinese Academy of Sciences)
Published on Feb 15, 2019in Human Molecular Genetics4.54
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University),
Hui Zhao2
Estimated H-index: 2
(CAS: Chinese Academy of Sciences)
+ 14 AuthorsYingqi Lin (JNU: Jinan University)
Published on May 1, 2018in Cell36.22
Sen Yan11
Estimated H-index: 11
(JNU: Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
Sen Yan11
Estimated H-index: 11
(JNU: Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Abstract Aging-related brain diseases consist of a number of important neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases, all of which have become more prevalent as the life expectancy of humans is prolonged. Age-dependent brain disorders are associated with both environmental insults and genetic mutations. For those brain disorders that are inherited, gene editing is an important tool for establishing animal models to investigate the pathogenesis of dise...
Published on Oct 1, 2017in Cell Research17.85
Hui Zhao2
Estimated H-index: 2
,
Zhuchi Tu7
Estimated H-index: 7
+ 12 AuthorsRui Tian1
Estimated H-index: 1
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3 -deficient non-human primate
Published on Sep 1, 2017in Cell Stem Cell21.46
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
Published on Feb 1, 2017in Scientific Reports4.01
Zhuchi Tu7
Estimated H-index: 7
,
Weili Yang9
Estimated H-index: 9
+ 10 AuthorsSu Yang9
Estimated H-index: 9
Published on Apr 28, 2016in Frontiers in Molecular Neuroscience3.72
Weili Yang9
Estimated H-index: 9
(CAS: Chinese Academy of Sciences),
Zhuchi Tu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(CAS: Chinese Academy of Sciences)
CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative ...
Published on Dec 1, 2015in Molecular Neurodegeneration8.27
Zhuchi Tu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences),
Weili Yang9
Estimated H-index: 9
(CAS: Chinese Academy of Sciences)
+ 2 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(CAS: Chinese Academy of Sciences)
Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals are more like humans than rodents, they make good models to identify the important pathological events that may be seen in humans but not in small animals; large animals are also very important for validating effective treatments or confirming therapeutic targets. Due to the lack of embryonic stem cell lines from large animals, it has bee...
Published on Jul 1, 2015in Human Molecular Genetics4.54
Yongchang Chen11
Estimated H-index: 11
(Kunming University of Science and Technology),
Yinghui Zheng3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
+ 12 AuthorsRuxiao Xing3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the targeted gene or cause the pathology seen in human disease. Addressing these issues is necessary if we are to generate large animal models of human diseases using CRISPR/Cas9. Here we used CRISPR/Cas9 to target the monkey dystrophin gene to create mu...
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