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Marie-Laure Machado
University of Caen Lower Normandy
11Publications
4H-index
117Citations
Publications 11
Newest
Published on 2019in Journal of Neuroscience Methods2.79
Marie-Laure Machado4
Estimated H-index: 4
(UNICAEN: University of Caen Lower Normandy),
Nicolas Lefevre16
Estimated H-index: 16
+ 5 AuthorsStephane Besnard9
Estimated H-index: 9
(UNICAEN: University of Caen Lower Normandy)
Abstract Background compared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might offer new tools for research purposes and for diagnosis in patients suffering from mild cognitive impairment or dementia. Comparison with existing methods Current software proposes a customizable VR environment combined with an analyser module based on regions of interest and some parameters ...
Published on Jun 1, 2019in Behavioural Brain Research2.77
A. Le Gall (French Institute of Health and Medical Research), Pascal Hilber8
Estimated H-index: 8
+ 6 AuthorsS. Besnard (AMU: Aix-Marseille University)
Abstract Earth’s gravity acts both as a mechanical stimulus on the body and as a sensory stimulus to the vestibular organ, which is transmitted into the brain. The vestibular system has been recently highlighted as the cornerstone of the multisensory cortex, of the dorsal hippocampus related to spatial cognition. Consequently, we have hypothesized that the vestibular sensory perception of gravity by the otoliths might also play a crucial role during the first stages of development in both sensor...
Published on Apr 1, 2019in Sleep Medicine Reviews10.52
Stephane Besnard9
Estimated H-index: 9
,
Brahim Tighilet16
Estimated H-index: 16
+ 5 AuthorsPaul F. Smith39
Estimated H-index: 39
Pascal Hilber8
Estimated H-index: 8
,
Jan Cendelin10
Estimated H-index: 10
(Charles University in Prague)
+ 3 AuthorsStephane Besnard9
Estimated H-index: 9
(French Institute of Health and Medical Research)
Abstract The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emotional reactivity, accumulating evidence indicates that both the vestibular and cerebellar systems are involved not only in motor coordination but also influence both cogni...
Published on Dec 1, 2018in Sleep Medicine Reviews10.52
Stephane Besnard9
Estimated H-index: 9
(French Institute of Health and Medical Research),
Brahim Tighilet16
Estimated H-index: 16
(AMU: Aix-Marseille University)
+ 5 AuthorsPaul F. Smith39
Estimated H-index: 39
(University of Otago)
Summary The vestibular system encodes linear and angular head motion supporting numerous functions from gaze stabilization and postural control, to high-level cortical functions involving spatial cognition, including self-body perception, verticality perception, orientation, navigation and spatial memory. At the brainstem and mesencephalic levels, the vestibular organs also influence postural blood pressure regulation, bone density and muscle composition via specific vestibulo-sympathetic effere...
Published on Oct 2, 2018in Frontiers in Physiology3.20
Costantino Balestra17
Estimated H-index: 17
('ENS Paris': École Normale Supérieure),
Marie-Laure Machado4
Estimated H-index: 4
(UNICAEN: University of Caen Lower Normandy)
+ 8 AuthorsPeter Germonpré13
Estimated H-index: 13
('ENS Paris': École Normale Supérieure)
In-situ evaluation of human brain performance and arousal remains challenging during operational circumstances, hence the need for a rapid, reliable and reproducible tool. Here we hypothesized that the Critical flicker fusion frequency (CFFF) reflecting/requiring visual integration, visuo-motor skills and decision-taking process might be a powerful, fast and simple tool in modified gravity environments. Therefore 11 male healthy volunteers were assessed for higher cognitive functions with CFFF d...
Published on Sep 1, 2018in Neuroscience Letters2.17
Alice Benoit1
Estimated H-index: 1
(French Institute of Health and Medical Research),
Stephane Besnard9
Estimated H-index: 9
(French Institute of Health and Medical Research)
+ 7 AuthorsPaul F. Smith39
Estimated H-index: 39
(University of Otago)
Abstract There is substantial evidence that loss of vestibular function impairs spatial learning and memory related to hippocampal (HPC) function, as well as increasing evidence that striatal (Str) plasticity is also implicated. Since the N -methyl- d -aspartate (NMDA) subtype of glutamate receptor is considered essential to spatial memory, previous studies have investigated whether the expression of HPC NMDA receptors changes following vestibular loss; however, the results have been contradicto...
Published on Jul 1, 2017in Neuroscience Letters2.17
Yiwen Zheng21
Estimated H-index: 21
(University of Otago),
Catherine M. Gliddon10
Estimated H-index: 10
(University of Otago)
+ 6 AuthorsStephane Besnard9
Estimated H-index: 9
(UNICAEN: University of Caen Lower Normandy)
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss of vestibular function, would alter cell proliferation in the hippocampal dentate gyrus of rats, by measuring the number of bromodeoxyuridine (BrdU)-in...
Published on May 1, 2014in Hippocampus3.27
Marie-Laure Machado4
Estimated H-index: 4
(UNICAEN: University of Caen Lower Normandy),
Véronique Lelong-Boulouard9
Estimated H-index: 9
+ 3 AuthorsStephane Besnard9
Estimated H-index: 9
Declarative memory refers to a spatial strategy using numerous sources of sensory input information in which visual and vestibular inputs are assimilated in the hippocampus. In contrast, procedural memory refers to a response strategy based on motor skills and familiar gestures and involves the striatum. Even if vestibular loss impairs hippocampal activity and spatial memory, vestibular-lesioned rats remain able to find food rewards during complex spatial memory task. Since hippocampal lesions i...
Published on Apr 1, 2013in Irbm0.93
Marie-Laure Machado4
Estimated H-index: 4
(French Institute of Health and Medical Research),
J.-Y. Guincestre1
Estimated H-index: 1
+ 6 AuthorsStéphane Besnard1
Estimated H-index: 1
Abstract Persons with cerebral palsy (CP) need to modify their lifestyle in order to carry out daily activities. Assistive technology facilitates communication and improves the domestic environment and mobility. The STARNAV Company has developed a Head Tracking System, Head Pilot, which uses a robust algorithm that measures, in real-time, head motion from a webcam. Head Pilot aims to control any informatic and domotic interface controlling the pointer of a PC. This work aims to create an assisti...
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