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Marie-Laure Machado
University of Caen Lower Normandy
EndocrinologyHippocampal formationPsychologyVestibular systemHippocampus
14Publications
5H-index
171Citations
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Publications 14
Newest
#1Marie-Laure Machado (UNICAEN: University of Caen Lower Normandy)H-Index: 5
#2Nicolas LefevreH-Index: 17
Last. Stephane Besnard (UNICAEN: University of Caen Lower Normandy)H-Index: 10
view all 8 authors...
Abstract Background Compared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might offer new tools for research purposes and for diagnosis in patients suffering from mild cognitive impairment or dementia. Comparison with existing methods Current software proposes a customizable VR environment combined with an analyser module based on regions of interest and some parameters ...
Source
#1A. Le Gall (French Institute of Health and Medical Research)H-Index: 1
#2P. HilberH-Index: 8
Last. S. Besnard (AMU: Aix-Marseille University)H-Index: 1
view all 9 authors...
Abstract Earth’s gravity acts both as a mechanical stimulus on the body and as a sensory stimulus to the vestibular organ, which is transmitted into the brain. The vestibular system has been recently highlighted as the cornerstone of the multisensory cortex, of the dorsal hippocampus related to spatial cognition. Consequently, we have hypothesized that the vestibular sensory perception of gravity by the otoliths might also play a crucial role during the first stages of development in both sensor...
1 CitationsSource
#1Stephane BesnardH-Index: 10
#2Brahim TighiletH-Index: 16
Last. Paul F. SmithH-Index: 41
view all 8 authors...
Source
#1P. HilberH-Index: 8
#2Jan Cendelin (Charles University in Prague)H-Index: 10
Last. Stephane Besnard (French Institute of Health and Medical Research)H-Index: 10
view all 6 authors...
Abstract The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emotional reactivity, accumulating evidence indicates that both the vestibular and cerebellar systems are involved not only in motor coordination but also influence both cogni...
4 CitationsSource
#1Costantino Balestra ('ENS Paris': École Normale Supérieure)H-Index: 18
#2Marie-Laure Machado (UNICAEN: University of Caen Lower Normandy)H-Index: 5
Last. Pierre Lafère ('ENS Paris': École Normale Supérieure)H-Index: 6
view all 11 authors...
In-situ evaluation of human brain performance and arousal remains challenging during operational circumstances, hence the need for a rapid, reliable and reproducible tool. Here we hypothesized that the Critical flicker fusion frequency (CFFF) reflecting/requiring visual integration, visuo-motor skills and decision-taking process might be a powerful, fast and simple tool in modified gravity environments. Therefore 11 male healthy volunteers were assessed for higher cognitive functions with CFFF d...
3 CitationsSource
#1Alice Benoit (French Institute of Health and Medical Research)H-Index: 1
#2Stephane Besnard (French Institute of Health and Medical Research)H-Index: 10
Last. Paul F. Smith (University of Otago)H-Index: 41
view all 10 authors...
Abstract There is substantial evidence that loss of vestibular function impairs spatial learning and memory related to hippocampal (HPC) function, as well as increasing evidence that striatal (Str) plasticity is also implicated. Since the N-methyl- d -aspartate (NMDA) subtype of glutamate receptor is considered essential to spatial memory, previous studies have investigated whether the expression of HPC NMDA receptors changes following vestibular loss; however, the results have been contradictor...
2 CitationsSource
#1Stephane Besnard (French Institute of Health and Medical Research)H-Index: 10
#2Brahim Tighilet (AMU: Aix-Marseille University)H-Index: 16
Last. Paul F. Smith (University of Otago)H-Index: 41
view all 8 authors...
Summary The vestibular system encodes linear and angular head motion supporting numerous functions from gaze stabilization and postural control, to high-level cortical functions involving spatial cognition, including self-body perception, verticality perception, orientation, navigation and spatial memory. At the brainstem and mesencephalic levels, the vestibular organs also influence postural blood pressure regulation, bone density and muscle composition via specific vestibulo-sympathetic effere...
3 CitationsSource
#1Yiwen Zheng (University of Otago)H-Index: 22
#2Catherine M. Gliddon (University of Otago)H-Index: 10
Last. Stephane Besnard (UNICAEN: University of Caen Lower Normandy)H-Index: 10
view all 9 authors...
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss of vestibular function, would alter cell proliferation in the hippocampal dentate gyrus of rats, by measuring the number of bromodeoxyuridine (BrdU)-in...
2 CitationsSource
#1Marie-Laure Machado (UNICAEN: University of Caen Lower Normandy)H-Index: 5
Last. Stephane BesnardH-Index: 10
view all 6 authors...
Declarative memory refers to a spatial strategy using numerous sources of sensory input information in which visual and vestibular inputs are assimilated in the hippocampus. In contrast, procedural memory refers to a response strategy based on motor skills and familiar gestures and involves the striatum. Even if vestibular loss impairs hippocampal activity and spatial memory, vestibular-lesioned rats remain able to find food rewards during complex spatial memory task. Since hippocampal lesions i...
12 CitationsSource
#1Marie-Laure Machado (French Institute of Health and Medical Research)H-Index: 5
#2J.-Y. GuincestreH-Index: 1
Last. Stéphane BesnardH-Index: 1
view all 9 authors...
Abstract Persons with cerebral palsy (CP) need to modify their lifestyle in order to carry out daily activities. Assistive technology facilitates communication and improves the domestic environment and mobility. The STARNAV Company has developed a Head Tracking System, Head Pilot, which uses a robust algorithm that measures, in real-time, head motion from a webcam. Head Pilot aims to control any informatic and domotic interface controlling the pointer of a PC. This work aims to create an assisti...
2 CitationsSource
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