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Wenshuai Wang
Shandong Agricultural University
14Publications
5H-index
54Citations
Publications 14
Newest
#1Wenshuai Wang (SDAU: Shandong Agricultural University)H-Index: 5
#2Honghong LiuH-Index: 2
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 10 authors...
Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice. The results of animal experiment in vivo showed that treatment with Al-DPS or En-DPS could improve the excessive level of lipid profiles in serum and liver, as well as strengthen ...
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#2Zheng GaoH-Index: 8
Last.Le JiaH-Index: 19
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As an irreversible and complex degenerative physiological process, the treatment for aging seems strategically necessary, and polysaccharides play important roles against aging owing to their abundant bioactivities. In this paper, the antioxidant and anti-aging activities of Flammulina velutipes polysaccharides (FPS) and its sulfated FPS (SFPS) on d-galactose-induced aging mice were investigated. The in vitro antioxidant activities demonstrated that SFPS had strong reducing power and superior sc...
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#1Wenshuai Wang (SDAU: Shandong Agricultural University)H-Index: 5
#2Xinling Song (SDAU: Shandong Agricultural University)H-Index: 7
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 8 authors...
Abstract The present work aimed to investigate the antioxidant, hepatic and renal protective effects of water-extractable polysaccharides (WPS) by Dictyophora indusiata fruiting body on high-fat emulsion-induced obese mice. The structural analysis indicated that WPS was the α-configurational heteropolysaccharide with the major monosaccharides of mannose and glucose, and the polydispersity of 1.77. The in vivo results showed that WPS administration could improve obesity-associated hepatic and ren...
1 CitationsSource
#1Huaping LiH-Index: 1
#2Huajie ZhaoH-Index: 9
Last.Le JiaH-Index: 19
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The present work mainly describes the preparation of acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigates the antioxidant and anti-aging effects in d-galactose-induced aging mice. The optimized procedure indicates the acetyl substitution degree of AMPS is 0.54 ± 0.04 under the conditions of a reaction time of 56 h, a reaction temperature of 37 °C, and 4 mL of added acetic anhydride. The in vitro analysis and in vivo animal experiments indicate that the AMPS could alle...
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#1Wenshuai Wang (SDAU: Shandong Agricultural University)H-Index: 5
#2Xinling Song (SDAU: Shandong Agricultural University)H-Index: 7
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 7 authors...
Abstract In the present work, we investigated the anti-hyperlipidemic, antioxidant and organic protection effects of acidic-extractable Dictyophora indusiata polysaccharides (Ac-DPS) on hyperlipidemic mice induced by high-fat emulsion. The results demonstrated that Ac-DPS had impressive abilities to mitigate oxidative stress by increasing the activities of antioxidant enzyme and reducing the contents of lipid peroxide. Moreover, lipid levels in serum were returned to normal status. Besides, Ac-D...
1 CitationsSource
#1Huajie Zhao (SDAU: Shandong Agricultural University)H-Index: 9
#2Huaping Li (SDAU: Shandong Agricultural University)H-Index: 1
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 9 authors...
Abstract A modified polysaccharide named MPCC from Coprinus comatus (MPCC) was obtained by the snailase hydrolysis. And the hepatoprotective effects on alcohol-induced liver injury and preliminary structure features were investigated. For in vivo hepatoprotective abilities, MPCC significantly attenuated the hepatic and serum lipid levels, obviously enhanced antioxidant enzyme activities, markedly improved alcohol metabolism system and inflammatory response, and mitigated alcohol-induced liver in...
2 CitationsSource
#1Zheng Gao (SDAU: Shandong Agricultural University)H-Index: 8
#2Xinchao Liu (SDAU: Shandong Agricultural University)H-Index: 2
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 12 authors...
Abstract The present work investigated the antioxidative, anti-inflammatory and pulmonary protective effects of enzymatic- and acid- hydrolysed mycelia polysaccharides (En-MPS and Ac-MPS) from Oudemansiella radicata on LPS-induced acute lung injury (ALI) mice. The results demonstrated that both En-MPS and Ac-MPS showed potential pulmonary protective effects by decreasing serum levels of hs-CRP and C3, increasing pulmonary enzyme values of SOD, GSH-Px, CAT and the level of T-AOC; reducing the act...
5 CitationsSource
#1Min Liu (SDAU: Shandong Agricultural University)H-Index: 6
#2Yufei LanH-Index: 2
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 9 authors...
The present work was designed to investigate the characterization, as well as the antioxidation and renoprotection in streptozocin (STZ)-induced diabetic mice, of exopolysaccharides (EPS) and the enzymatic-EPS (EEPS) and acidic-EPS (AEPS) hydrolysates, which were separated from the fermentation liquor of Hypsizigus marmoreus. Animal results demonstrated that EPS, EEPS and AEPS had potential antioxidant and renoprotective effects, especially EEPS. Additionally, they were the most effective, refle...
2 CitationsSource
#1Yuhan Dong (SDAU: Shandong Agricultural University)H-Index: 3
#2Yanran Qi (Jiangnan University)H-Index: 2
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
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Abstract The aims of this work were to investigate the antioxidant, anti-hyperlipidemia and hepatic protection of Morehella esculenta polysaccharide (MPS) from fruiting body and its enzyme-assisted MPS (EnMPS). The in vitro scavenging rates of EnMPS at 600 mg/L on superoxide, hydroxyl and 1,1‑diphenyl‑2‑pyrazole hydrazide (DPPH) radicals were 76.92 ± 2.61%, 66.74 ± 2.56% and 75.78 ± 2.4%, higher than those of MPS, respectively. Animals experiments showed that the EnMPS exhibited superior abiliti...
2 CitationsSource
#1Xinling Song (SDAU: Shandong Agricultural University)H-Index: 7
#2Qiang Shen (SDAU: Shandong Agricultural University)H-Index: 1
Last.Le Jia (SDAU: Shandong Agricultural University)H-Index: 19
view all 11 authors...
Abstract In the present study, we investigated the antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus geesteranus (IMPP) to address acute alcoholic liver diseases (ALD). Animal studies have demonstrated that the hepatic parameters of CYP2E1, MPO, TC, ALT, AST and ALP, HDLC, LDL-C and VLDL-C were improved; the inflammatory factor levels, including TNF-α, IL-1β and IL-6, were decreased; the hepatic ADH and ALDH activities were inhibited; the activitie...
15 CitationsSource
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