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Jack A. Sargeant
Loughborough University
11Publications
4H-index
27Citations
Publications 12
Newest
#1Scott A. Willis (NIHR: National Institute for Health Research)H-Index: 1
#2Jack A. Sargeant (NIHR: National Institute for Health Research)H-Index: 4
Last.James A. King (NIHR: National Institute for Health Research)H-Index: 16
view all 16 authors...
Background: Hepatokines such as fibroblast growth factor 21 (FGF21), leukocyte cell-derived chemotaxin 2 (LECT2), fetuin-A, fetuin-B and selenoprotein P (SeP) are liver-derived proteins which are modulated by chronic energy status and metabolic disease. Emerging data from rodent and cell models indicate that hepatokines may be sensitive to acute nutritional manipulation; however, data in humans are lacking. Objective: To investigate the influence of hyper-energetic, high-fat feeding on circulati...
1 CitationsSource
#1Scott A. Willis (Lboro: Loughborough University)H-Index: 1
#2Jack A. Sargeant (Lboro: Loughborough University)H-Index: 4
Last.James A. King (Lboro: Loughborough University)H-Index: 16
view all 7 authors...
Fibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines that are modulated by metabolic stresses. This study investigated whether exer...
1 CitationsSource
#1Jack A. Sargeant (University of Leicester)H-Index: 4
#2Joseph Henson (University of Leicester)H-Index: 11
Last.Melanie J. Davies (University of Leicester)H-Index: 82
view all 6 authors...
Weight loss is an important goal in the management of several chronic conditions, including type 2 diabetes mellitus, and pharmacological therapies that aid weight loss are appealing. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) are novel glucose-lowering therapies that have been shown to induce clinically significant reductions in body weight. However, this weight loss may not be attributed solely to fat mass (FM). Given the import...
Source
#1David J. Clayton (Lboro: Loughborough University)H-Index: 9
#2Jack Biddle (Lboro: Loughborough University)H-Index: 1
Last.Lewis J. James (Lboro: Loughborough University)H-Index: 13
view all 9 authors...
Intermittent energy restriction (IER) involves short periods of severe energy restriction interspersed with periods of adequate energy intake, and can induce weight loss. Insulin sensitivity is impaired by short-term, complete energy restriction, but the effects of IER are not well known. In randomised order, fourteen lean men (age: 25 (sd 4) years; BMI: 24 (sd 2) kg/m2; body fat: 17 (4) %) consumed 24-h diets providing 100 % (10 441 (sd 812) kJ; energy balance (EB)) or 25 % (2622 (sd 204) kJ; e...
Source
#1Jack A. Sargeant (NIHR: National Institute for Health Research)H-Index: 4
#2Laura J. Gray (University of Leicester)H-Index: 63
Last.James A. King (NIHR: National Institute for Health Research)H-Index: 16
view all 8 authors...
This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also examined its effect on hepatic insulin sensitivity in individuals with or at increased risk of NAFLD. Analyses were restricted to studies using magnetic resonance spectroscopy or liver biopsy for the measurement of IHTG and isotope-labelled glucose tra...
4 CitationsSource
#1Jack A. Sargeant (Leicester General Hospital)H-Index: 4
#2Thomas Yates (Leicester General Hospital)H-Index: 32
Last.Joseph Henson (Leicester General Hospital)H-Index: 11
view all 7 authors...
Source
#1Jack A. Sargeant (Lboro: Loughborough University)H-Index: 4
#2Guruprasad P. Aithal (University of Nottingham)H-Index: 40
Last.James A. King (Lboro: Loughborough University)H-Index: 16
view all 12 authors...
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and other metabolic parameters. This study investigated differences in adiposity status on 5 novel hepatokines and characterised their response to acute moderate-intensity exercise in groups of normal-weight and overweight/obese men. Twenty-two men were recruited into normal-weight and overweight/obese groups (body mass index: 18.5 to 24.9 and 25.0 to 34.9 kg·m−2). Each completed 2 experimental trials, exercis...
5 CitationsSource
#1Jack A. Sargeant (Lboro: Loughborough University)H-Index: 4
#2Stephen Bawden (University of Nottingham)H-Index: 4
Last.James A. King (Lboro: Loughborough University)H-Index: 16
view all 12 authors...
Purpose This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT).
4 CitationsSource
#1Scott A. WillisH-Index: 1
#2Jack A. SargeantH-Index: 4
Last.James A. KingH-Index: 16
view all 4 authors...
This is an abstract of a paper presented at the European Congress on Obesity, Vienna, May 23-26, 2018. This is an Open Access Article. It is published by Karger under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
Source
#1Jessica A. Douglas (University of Birmingham)H-Index: 5
#2James A. King (Lboro: Loughborough University)H-Index: 16
Last.David J. Stensel (Lboro: Loughborough University)H-Index: 27
view all 8 authors...
Acute effects of exercise on appetite, ad libitum energy intake and appetite-regulatory hormones in lean and overweight/obese men and women
14 CitationsSource
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