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Zhengtao Liu
Zhejiang University
Fatty liverLiver transplantationDiabetes mellitusMedicineBiology
14Publications
5H-index
471Citations
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Publications 15
Newest
Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis is a contributor for inferior graft quality. But its impact and safety on transplantation was less assessed in Chinese patients. Graft steatosis and related information involved in recipients, donors and surgical procedures were retrospectively collected from 239 patients. Donor macrosteatosis (MaS) caused about 2.14 and 2.80 folds of increment on patient and graft mort...
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#1Zhengtao Liu (ZJU: Zhejiang University)H-Index: 5
#2Jun-Jun Jia (ZJU: Zhejiang University)H-Index: 6
Last. Shusen Zheng (ZJU: Zhejiang University)H-Index: 42
view all 6 authors...
Background: Currently, 30% macrovesicular steatosis (MaS) content is usually assigned empirically as the boundary between “use” or “refuse” a donor liver for liver transplantation; however, this cut-off is questionable due to the lack of systemic evidence of the efficiency relative to prognosis prediction. Clinicians have tried to identify the threshold for optimized utilization of marginal steatotic allografts, but controversy exists among different studies. Aim: Our study aimed to systematical...
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#1Zhengtao Liu (KTH: Royal Institute of Technology)H-Index: 5
#2Cheng Zhang (KTH: Royal Institute of Technology)H-Index: 15
Last. Adil Mardinoglu (Chalmers University of Technology)H-Index: 29
view all 13 authors...
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) has been associated with altered expression of liver-specific genes including pyruvate kinase liver and red blood cell (PKLR), patatin-like phospholipase domain containing 3 (PNPLA3) and proprotein convertase subtilisin/kexin type 9 (PCSK9). Here, we inhibited and overexpressed the expression of these three genes in HepG2 cells, generated RNA-seq data before and after perturbation and revealed the al...
3 CitationsSource
#1Zhengtao Liu (ZJU: Zhejiang University)H-Index: 5
#2Shuheng Liang (Boston Children's Hospital)H-Index: 1
Last. Adil Mardinoglu (Chalmers University of Technology)H-Index: 29
view all 6 authors...
Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1248 and 6020 subjects, respectively. Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve=0.81, ...
3 CitationsSource
#1Sunjae Lee (KTH: Royal Institute of Technology)H-Index: 11
#2Cheng Zhang (KTH: Royal Institute of Technology)H-Index: 15
Last. Adil Mardinoglu (Chalmers University of Technology)H-Index: 29
view all 13 authors...
Biological networks provide new opportunities for understanding the cellular biology in both health and disease states. We generated tissue specific integrated networks (INs) for liver, muscle and adipose tissues by integrating metabolic, regulatory and protein-protein interaction networks. We also generated human co-expression networks (CNs) for 46 normal tissues and 17 cancers to explore the functional relationships between genes as well as their relationships with biological functions, and in...
11 CitationsSource
#1Zhengtao Liu (KTH: Royal Institute of Technology)H-Index: 5
#2Adil Mardinoglu (Chalmers University of Technology)H-Index: 29
Last. Shuping Que (KTH: Royal Institute of Technology)H-Index: 3
view all 3 authors...
1 CitationsSource
#1Zhengtao LiuH-Index: 5
#2Shuping Que (KTH: Royal Institute of Technology)H-Index: 3
Last. Adil MardinogluH-Index: 29
view all 3 authors...
Rediscussion on Linearity Between Fibrosis Stages and Mortality Risk in Nonalcoholic Fatty Liver Disease Patients
1 CitationsSource
#1Zhengtao Liu (ZJU: Zhejiang University)H-Index: 5
#2Shuping Que (Boston Children's Hospital)H-Index: 3
Last. Luca Valenti (University of Milan)H-Index: 48
view all 7 authors...
The impact of Transmembrane 6 superfamily member 2 (TM6SF2) E167K variant, which causes hepatocellular fat retention by altering lipoprotein secretion, on liver damage and metabolic traits in chronic hepatitis C patients is still debated. We performed a systematic review and meta-analysis to clarify this relationship. Four studies with a total of 4325 patients were included. The risk of histologically-determined advanced steatosis, fibrosis, and cirrhosis (but not of severe inflammation) were in...
3 CitationsSource
#1Mathias Uhlén (KTH: Royal Institute of Technology)H-Index: 93
#2Cheng Zhang (KTH: Royal Institute of Technology)H-Index: 15
Last. Fredrik Pontén (Uppsala University)H-Index: 58
view all 27 authors...
Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation o...
392 CitationsSource
#1Sunjae Lee (KTH: Royal Institute of Technology)H-Index: 11
#2Cheng Zhang (KTH: Royal Institute of Technology)H-Index: 15
Last. Adil Mardinoglu (Chalmers University of Technology)H-Index: 29
view all 24 authors...
We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co-expression networks (CNs) for 46 human tissues and liver cancer to explore the functional relationships between genes and examined the overlap between functional and physical interactions. Since increased de novo lipogenesis is a characteristic of nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC), we inve...
28 CitationsSource
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