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Filipa Vlahova
University College London
4Publications
3H-index
16Citations
Publications 4
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#1Filipa Vlahova (UCL: University College London)H-Index: 3
#2Kate E. Hawkins (UCL: University College London)H-Index: 3
Last.Pascale V. Guillot (UCL: University College London)H-Index: 4
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Expression of OCT4A is one of the hallmarks of pluripotency, defined as a stem cell’s ability to differentiate into all the lineages of the three germ layers. Despite being defined as non-tumorigenic cells with high translational potential, human mid-trimester amniotic fluid stem cells (hAFSCs) are often described as sharing features with embryonic stem cells, including the expression of OCT4A, which could hinder their clinical potential. To clarify the OCT4A status of hAFSCs, we first undertook...
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#1Michelangelo Corcelli (UCL: University College London)H-Index: 5
#2Kate E. Hawkins (UCL: University College London)H-Index: 3
Last.Pascale V. Guillot (UCL: University College London)H-Index: 4
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Human amniotic fluid contains two morphologically-distinct sub-populations of stem cells with regenerative potential, spindle-shaped (SS-hAFSCs) and round-shaped human amniotic fluid stem cells (RS-hAFSCs). However, it is unclear whether morphological differences correlate with functionality, and this lack of knowledge limits their translational applications. Here, we show that SS-hAFSCs and RS-hAFSCs differ in their neuro-protective ability, demonstrating that a single contralateral injection o...
4 CitationsSource
Human mesenchymal stem cells (MSCs) have huge potential for regenerative medicine. In particular, the use of pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) overcomes the hurdle of replicative senescence associated with the in vitro expansion of primary cells and has increased therapeutic benefits in comparison to the use of various adult sources of MSCs in a wide range of animal disease models. On the other hand, fetal MSCs exhibit faster growth kinetics and possess longer telom...
9 CitationsSource
#1Kwan-Leong Hau (UCL: University College London)H-Index: 3
#2Anna Maria Ranzoni (UCL: University College London)H-Index: 3
Last.Pascale V. Guillot (UCL: University College London)H-Index: 4
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The human amniotic fluid stem cell (hAFSC) population consists of two morphologically distinct subtypes, spindle-shaped and round-shaped cells (SS-hAFSCs and RS-hAFSCs). Whilst SS-hAFSCs are routinely expanded in mesenchymal-type (MT) conditions, we previously showed that they acquire broader differentiation potential when cultured under embryonic-type (ET) conditions. However, the effects of culture conditions on RS-hAFSCs have not been determined. Here, we show that culturing RS-hAFSCs under E...
3 CitationsSource
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