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Clare Bycroft
Wellcome Trust Centre for Human Genetics
PeninsulaHaplotypePopulationEvolutionary biologyBiology
6Publications
4H-index
641Citations
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Publications 6
Newest
#1A. Raveane (UNIPV: University of Pavia)H-Index: 1
#2S. Aneli (University of Oxford)H-Index: 1
Last. Cristian Capelli (University of Oxford)H-Index: 31
view all 48 authors...
European populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudie...
7 CitationsSource
#1Clare Bycroft (Wellcome Trust Centre for Human Genetics)H-Index: 4
Last. Simon Myers (University of Oxford)H-Index: 41
view all 7 authors...
The Iberian Peninsula is linguistically diverse and has a complex demographic history, including a centuries-long period of Muslim rule. Here, we study the fine-scale genetic structure of its population, and the genetic impacts of historical events, leveraging powerful, haplotype-based statistical methods to analyse 1413 individuals from across Spain. We detect extensive fine-scale population structure at extremely fine scales (below 10 Km) in some regions, including Galicia. We identify a major...
11 CitationsSource
#1Alessandro Raveane (UNIPV: University of Pavia)H-Index: 4
#2Serena Aneli (UNITO: University of Turin)H-Index: 3
Last. Cristian Capelli (University of Oxford)H-Index: 31
view all 45 authors...
European populations display low genetic diversity as the result of long term blending of the small number of ancient founding ancestries. However it is still unclear how the combination of ancient ancestries related to early European foragers, Neolithic farmers and Bronze Age nomadic pastoralists can fully explain genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the overall continental diversity, but to date have been sys...
4 CitationsSource
#1Jonathan Marchini (University of Oxford)H-Index: 58
#2Clare Bycroft (University of Oxford)H-Index: 4
Last. Peter Donnelly (University of Oxford)H-Index: 95
view all 18 authors...
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size and scope. A rich variety of phenotypic and health-related information is available on each participant, including biological measurements, lifestyle indicators, biomarkers in blood and urine, and imaging of the body and brain. Follow-up information i...
337 CitationsSource
#1Clare Bycroft (University of Oxford)H-Index: 4
Last. Simon Myers (University of Oxford)H-Index: 41
view all 7 authors...
Genetic differences within or between human populations (population structure) has been studied using a variety of approaches over many years. Recently there has been an increasing focus on studying genetic differentiation at fine geographic scales, such as within countries. Identifying such structure allows the study of recent population history, and identifies the potential for confounding in association studies, particularly when testing rare, often recently arisen variants. The Iberian Penin...
3 CitationsSource
#1Clare Bycroft (University of Oxford)H-Index: 4
#2C. Freeman (University of Oxford)H-Index: 19
Last. Jonathan Marchini (University of Oxford)H-Index: 58
view all 15 authors...
The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and health-related information is available on each participant, making the resource unprecedented in its size and scope. Here we describe the genome-wide genotype data (~805,000 markers) collected on all individuals in the cohort and its quality control procedures. Genotype data on this scale offers novel opportunities...
284 CitationsSource
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