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Richard Morgan
University of Bradford
Hox geneCancerCancer researchTranscription factorBiology
222Publications
37H-index
4,429Citations
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Publications 126
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#1Einthavy Arunachalam (University of Surrey)H-Index: 1
#2Guy R. Simpson (University of Surrey)H-Index: 15
Last. Hardev Pandha (University of Surrey)H-Index: 47
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Introduction: Triple Negative Breast Cancer (TNBC) is a heterogeneous disease, clinically defined for its aggressive tumour behaviour, metastatic ability and poor prognosis. Homeobox (HOX) genes are a family of homeodomain-containing transcription factors, which establish and maintain the identity and fate of cells and tissues during normal embryogenesis and organ development. A total of 39 HOX genes exist, located in four clusters (A-D) on different chromosomes. HOX genes are dysregulated in mo...
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#1Richard Morgan (University of Bradford)H-Index: 37
#2Hardev Pandha (University of Surrey)H-Index: 47
PBX3 is a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, members of which have extensive roles in early development and some adult processes. A number of features distinguish PBX3 from other PBX proteins, including the ability to form specific and stable interactions with DNA in the absence of cofactors. PBX3 has frequently been reported as having a role in the development and maintenance of a malignant phenotype, and high levels of PBX3 tumor expression hav...
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Urothelial carcinoma of the urinary bladder (UCB) or Bladder cancer remains a major health problem with high morbidity and mortality rates, especially in the western world. UCB is also associated with the highest cost per patient. In recent years numerous markers have been evaluated for suitability in UCB detection and surveillance. However, to date none of these markers can replace or even reduce the use of routine tools (cytology and cystoscopy). Our current study described the UCB's extensive...
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#1Praveena Idaikkadar (University of Surrey)H-Index: 1
#2Richard Morgan (University of Bradford)H-Index: 37
Last. Agnieszka Michael (University of Surrey)H-Index: 21
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HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing...
4 CitationsSource
#1Richard MorganH-Index: 37
Last. Hardev S. PandhaH-Index: 1
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1 CitationsSource
#1Monika PrimonH-Index: 2
#2Keith D. HunterH-Index: 18
Last. Richard MorganH-Index: 37
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The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell ...
3 CitationsSource
#1Natasha Punia (University of Surrey)H-Index: 1
#2Monika Primon (University of Bradford)H-Index: 2
Last. Richard Morgan (University of Bradford)H-Index: 37
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Engrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a range of cancers. In addition to transcriptional regulation, it is secreted by cells and taken up by others through a mechanism that is yet to be fully elucidated. In this study, the distribution of EN2 protein in cells was evaluated using immunofluorescence with a set of antibodies raised against overlapping epitopes a...
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#1El-Habib Dakir (University of Bradford)H-Index: 1
#2Adam Pickard ('QUB': Queen's University Belfast)H-Index: 12
Last. Mohamed El-Tanani (University of Bradford)H-Index: 18
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Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to suppress cell growth of breast cancer cells in vitro. In this study we further explore the inhibitory effects of this molecule in cancer cells. We found that Pimozide inhibited cell proliferation in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells and A549 lung cancer cells. Furthermore, we found that Pimozide also promoted apoptosis as demonstrated by cell cycle arrest and induction of dou...
5 CitationsSource
#1Sophie E. McGrathH-Index: 5
#2Nicola E. AnnelsH-Index: 23
Last. Agnieszka MichaelH-Index: 21
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BACKGROUND: Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. METHODS We evaluated 8 Epithelial ovarian cancer cell lines, along with >100 surgical specimens from the Royal Surrey C...
#1Sophie E. McGrath (University of Surrey)H-Index: 5
#2Nicola E. Annels (University of Surrey)H-Index: 23
Last. Agnieszka Michael (University of Surrey)H-Index: 21
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Background Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker.
1 CitationsSource
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