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Richard Morgan
University of Bradford
126Publications
25H-index
2,168Citations
Publications 122
Newest
#1Natasha Punia (University of Surrey)H-Index: 1
#2Monika Primon (University of Bradford)H-Index: 1
Last.Richard Morgan (University of Bradford)H-Index: 25
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Engrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a range of cancers. In addition to transcriptional regulation, it is secreted by cells and taken up by others through a mechanism that is yet to be fully elucidated. In this study, the distribution of EN2 protein in cells was evaluated using immunofluorescence with a set of antibodies raised against overlapping epitopes a...
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#2Richard MorganH-Index: 25
Last.Agnieszka MichaelH-Index: 21
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HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing...
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#1Monika PrimonH-Index: 1
#2Keith D. HunterH-Index: 17
Last.Richard MorganH-Index: 25
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The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell ...
3 CitationsSource
#1Sophie E. McGrath (University of Surrey)H-Index: 5
#2Nicola E. Annels (University of Surrey)H-Index: 23
Last.Agnieszka Michael (University of Surrey)H-Index: 21
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Background Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker.
1 CitationsSource
#1Christopher Platais (University of Sheffield)H-Index: 2
#2Raghu Radhakrishnan (University of Sheffield)H-Index: 11
Last.Keith D. Hunter (University of Pretoria)H-Index: 17
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High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein binding to PBX cofactors by the use of synthetic peptides, such as HXR9, results in apoptosis in multiple cancers. Activity of the HOX-PBX inhibiting peptide HXR9 was tested in immortalised normal oral (NOK), potenti...
2 CitationsSource
#1El-Habib Dakir (University of Bradford)H-Index: 1
#2Adam Pickard ('QUB': Queen's University Belfast)H-Index: 11
Last.Mohamed El-Tanani (University of Bradford)H-Index: 18
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Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to suppress cell growth of breast cancer cells in vitro. In this study we further explore the inhibitory effects of this molecule in cancer cells. We found that Pimozide inhibited cell proliferation in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells and A549 lung cancer cells. Furthermore, we found that Pimozide also promoted apoptosis as demonstrated by cell cycle arrest and induction of dou...
5 CitationsSource
#1Sophie E. McGrathH-Index: 5
#2Nicola E. AnnelsH-Index: 23
Last.Agnieszka MichaelH-Index: 21
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BACKGROUND: Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. METHODS We evaluated 8 Epithelial ovarian cancer cell lines, along with >100 surgical specimens from the Royal Surrey C...
1 CitationsSource
#1Raed A. AlharbiH-Index: 2
#2Hardev PandhaH-Index: 46
Last.Richard MorganH-Index: 25
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The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playing a particularly significant role in acute myeloid leukemia (AML), the relationship between HOX gene expression and patient survival has not been evaluated (with the exception of HOXA9), and the mecha...
12 CitationsSource
#1Benjamin BoyerinasH-Index: 6
#2Sara M. MillerH-Index: 2
Last.Richard MorganH-Index: 25
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Numerous immune-suppressive mechanisms exist within the tumor microenvironment that may hinder chimeric antigen receptor (CAR) T cell efficacy. One such mechanism is mediated by TGF-β, a cytokine secreted by tumor cells and infiltrating suppressive immune cells that directly inhibits effector T cell activity. Effector T cells express the TGF-β receptors TGFBR1 and TGFBR2, and exposure of T cells to TGF-β induces phosphorylation of the major TGF-β signal mediators SMAD2 and SMAD3. Phosphorylated ...
2 CitationsSource
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