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Italo Rodrigo Calori
Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
MicelleMonomerChemistryDrug deliveryPhotochemistry
5Publications
4H-index
57Citations
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Publications 5
Newest
#1Cristiano Ceron Jayme (USP: University of São Paulo)H-Index: 2
Last. Antonio Claudio Tedesco (USP: University of São Paulo)H-Index: 37
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Abstract The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. I...
3 CitationsSource
#1Diogo Silva Pellosi (USP: University of São Paulo)H-Index: 12
Last. Antonio Claudio Tedesco (USP: University of São Paulo)H-Index: 37
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Abstract Nanotechnology development provides new strategies to treat cancer by integration of different treatment modalities in a single multifunctional nanoparticle. In this scenario, we applied the multifunctional Pluronic P123/F127 mixed micelles for Verteporfin-mediated photodynamic therapy in PC3 and MCF-7 cancer cells. Micelles functionalization aimed the targeted delivery by the insertion of biotin moiety on micelle surface and fluorescence image-based through rhodamine-B dye conjugation ...
11 CitationsSource
#1Camila Fabiano de Freitas (UEM: Universidade Estadual de Maringá)H-Index: 6
#2Diogo Silva Pellosi (UEM: Universidade Estadual de Maringá)H-Index: 12
Last. Noboru Hioka (UEM: Universidade Estadual de Maringá)H-Index: 20
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It was evaluated the properties of the xanthene dyes Erythrosin B, Eosin Y and theirs Methyl, Butyl and Decyl ester derivatives as possible photosensitizers (PS) for photodynamic treatments. The more hydrophobic dyes self-aggregate in water/ethanol solutions above 70% water (vol/vol) in the mixture. In buffered water, these PS were encapsulated in Pluronic polymeric surfactants of P-123 and F-127 by two methodologies: direct addition and the thin-film solid dispersion methods. The thin-film soli...
12 CitationsSource
#1Italo Rodrigo Calori (FFCLRP: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto)H-Index: 4
#2Antonio Claudio Tedesco (FFCLRP: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto)H-Index: 37
Abstract Aluminum phthalocyanine chloride (AlClPc) is a second-generation photodynamic therapy (PDT) photosensitizer characterized for its high hydrophobicity and self-aggregation tendency in aqueous media, which hamper its potential application. Aiming at AlClPc solubilization we proposed here the use of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) at different proportions to form mixed lipid vesicles (LVs) as a drug delivery system. LVs ...
12 CitationsSource
#1Cristiano Ceron Jayme (FFCLRP: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto)H-Index: 1
#2Italo Rodrigo Calori (FFCLRP: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto)H-Index: 4
Last. Antonio Claudio Tedesco (FFCLRP: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto)H-Index: 37
view all 3 authors...
Abstract This study evaluated the behavior of aluminum chloride phthalocyanine in a binary water/ethanol mixture using electronic absorption spectroscopy and static and time-resolved fluorescence spectroscopy. The electronic absorption spectra, resonance light scattering and fluorescence quenching of aluminum chloride phthalocyanine in water/ethanol mixtures were studied at several concentrations. The electronic absorption spectra and fluorescence quenching changed significantly at approximately...
19 CitationsSource
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