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Ying Xu
Shanghai Jiao Tong University
8Publications
7H-index
310Citations
Publications 8
Newest
#1Ying Xu (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2JinBao Liu (Guangzhou Medical University)H-Index: 1
Last.Guo-Qiang Chen (SJTU: Shanghai Jiao Tong University)H-Index: 46
view all 6 authors...
Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compound...
#1Jie Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Ying Xu (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last.Guo-Qiang Chen (SJTU: Shanghai Jiao Tong University)H-Index: 46
view all 6 authors...
Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid tumors. The transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of HIF-1α, an oxygen-sensitive subunit of HIF-1, are mainly modulated by various post-translational modifications. Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcriptional activity o...
#1Zhu Mei (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2HuiKe Jiao (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Ying Xu (SJTU: Shanghai Jiao Tong University)H-Index: 7
view all 6 authors...
We recently report that the expression of polycomb chromobox 4 (Cbx4) is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma (HCC) patients and it enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha (HIF-1α). Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell line...
#1Jie Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Ying Xu (CAS: Chinese Academy of Sciences)H-Index: 7
Last.Guo-Qiang Chen (CAS: Chinese Academy of Sciences)H-Index: 46
view all 13 authors...
Summary Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1. ...
#1Qingkang Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2N. Xia (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last.Jinke Cheng (SJTU: Shanghai Jiao Tong University)H-Index: 23
view all 10 authors...
Abstract SUMO-specific protease 1 (SENP1) is a member of de-SUMOylation protease family and has an important role in the regulation of androgen receptor-dependent transcription and hypoxia signaling. This activity profile of SENP1 prompted us to investigate whether SENP1 is involved in the pathogenesis of prostate cancer. In previous studies, we have detected the overexpression of SENP1 in both precancerous prostate intraepithelial neoplasia (PIN) lesions and prostate cancer tissue samples from ...
#1Ying Xu (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Jie Li (MOE: Chinese Ministry of Education)H-Index: 1
Last.Guo-Qiang Chen (SJTU: Shanghai Jiao Tong University)H-Index: 46
view all 6 authors...
SUMO conjugation emerges as an important mechanism in regulating protein localization, stability and activity. SUMOylation is a dynamic process and can be reversed by a family of sentrin/SUMO-specific proteases (SENPs). However, the biological roles of SENPs in cellular processes are largely unknown. Here, we show that SENP1, a member of SENP family, is overexpressed in most of colon cancer tissues. Silencing of SENP1 expression inhibits cell growth with G1 arrest in vitro and in nude mice and c...
#1Ying Xu (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Yong Zuo (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last.Jinke Cheng (SJTU: Shanghai Jiao Tong University)H-Index: 23
view all 10 authors...
Abstract SENP1 (SUMO-specific protease 1) has been shown to be essential for the stability and activity of hypoxia-inducible factor 1 (HIF-1α) under hypoxia conditions. However, it is unknown how SENP1 activation and hypoxia signaling are coordinated in the cellular response to hypoxia. Here, we report the essential role of SENP1 in endothelial cells as a positive regulator of hypoxia-driven VEGF production and angiogenesis. SENP1 expression is increased in endothelial cells following exposure t...
#1Xu Yun Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Ting Ting Chen (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last.Ke Wen Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 5
view all 9 authors...
The expression of galectin-1, one of the most important lectins participating in the malignant tumor development, has been shown to be regulated by hypoxia, but its exact mechanism remains elusive. Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1α protein, an oxygen-sensitive subunit of HIF-1 that is a master factor for cellular response to hypoxia, significantly increases galectin-1 expression in both messenger RNA and protein levels in all four colorectal cancer (CRC) ...
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