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Xiaobo Sun
Academy of Medical Sciences, United Kingdom
12Publications
7H-index
105Citations
Publications 12
Newest
#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Yuanyuan Dai (Jiangsu University)
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
This research investigated the influence of extremely low frequency magnetic fields (ELF-MF; 50 Hz, 8 mT, 4 h per day, for 28 days) on calcium ion signaling and the double messenger system in the hippocampus of mice. Messengers that were studied included: G-protein, Ins(1,4,5)P3 (IP3), diacylglycerol (DAG), cAMP-dependent protein kinase (PKA), and Ca2+-dependent protein kinase C (PKC). The results showed that ELF-MF caused an increase in the levels of Gi protein, IP3, DAG, PKA and PKC beta, calc...
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#1Chunchun Yin (Jiangsu University)H-Index: 2
#2Xiaoping Luo (Jiangsu University)H-Index: 7
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
Abstract The present study investigated the protective effects of lotus seedpod procyanidins (LSPCs) on extremely low frequency electromagnetic field (ELF-EMF)-induced neurotoxicity in primary cultured rat hippocampal neurons and the underlying molecular mechanism. The results of MTT, morphological observation, superoxide dismutase (SOD) and malondialdehyde (MDA) assays showed that compared with control, incubating neurons under ELF-EMF exposure significantly decreased cell viability and increas...
6 CitationsSource
#1Xiaoping Luo (Jiangsu University)H-Index: 7
#2Meng Chen (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 9 authors...
Abstract With the increasing use of electromagnetic technology, the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on biological systems, central neurotransmitter systems, and human health have attracted extensive attention worldwide. In this study, lotus seedpod procyanidins (LSPCs) were evaluated for their protective effects on ELF-EMF induced oxidative stress injury in mice. Sixty male ICR mice were used for the experiment. The mice were randomly divided into five equal g...
7 CitationsSource
#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Xiaoping Luo (Jiangsu University)H-Index: 7
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 9 authors...
Abstract Procyanidins from Castanea mollissima Bl. shell (CSPCs) induced autophagy and apoptosis in HepG2 cells and its mechanism remains to be examined. In this paper, autophagy was measured by the lipid modification of light chain-3 (LC3) and the formation of autophagosomes. Hoechst 33258 staining and flow cytometer analysis were used to measure apoptosis. The western blot analysis was used to examine the effects of CSPCs on the expression of LC3, PI3K, phosphorylation of AKT, mTOR, Bcl-2, Bad...
8 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Hui Xu (Jiangsu University)H-Index: 1
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 7 authors...
Abstract In this study, autophagic effect of procyanidins from lotus ( Nelumbo nucifera Gaertn.) seedpod (LSPCs) on human hepatoma G2 (HepG2) cells, and the inherent correlation between autophagic levels and reactive oxygen species (ROS) generation were investigated. The results showed that LSPCs increased monodansylcadaverine (MDC) fluorescence intensity and LC3-I/LC3-II conversion in HepG2 cells. In addition, the typically autophagic characteristics (autophagosomes and autolysosomes) were obse...
5 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Jiajia Ke (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 6 authors...
Abstract The autophagy of human hepatoma G2 (HepG2) cells induced by procyanidins from chestnut ( Castanea mollissima Bl.) shell (CSPCs) was investigated, and the inherent relationship between autophagic levels and reactive oxygen species (ROS) generation was studied. The results showed that CSPCs induced HepG2 cell death in a time- and concentration-dependent manner, increased the accumulation of autophagolysosomes and microtubule-associated proteins light chain 3-II (LC3-II, a marker of autoph...
11 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Zhigao Wang (Jiangsu University)H-Index: 2
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
Lotus seedpod procyanidins (LSPCs) could effectively prevent learning and memory damage and oxidative damage caused by extremely low frequency electromagnetic field (ELF-EMF) exposure. However, LSPCs protect neurons from ELF-EMF-induced damage by mechanisms currently not clear. An excessive release of glutamate is considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases. In this study we determined whether the ELF-EMF (50 Hz, 8 mT, 28 days) exposure in...
16 CitationsSource
#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Jiajia Ke (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 10 authors...
Abstract Significant cytotoxic effects of procynadins from chestnut ( Castanea mollissima Bl.) s hell (CSPC) on human hepatoma G2 (HepG2) cells were found in vitro . CSPC could inbibit HepG2 proliferation in a dose-dependent manner (100–400 μg/mL), arrest cell cycle in the G 0 /G 1 phase, induce apoptosis and trigger necrosis of HepG2. Proapoptotic effect of CSPC was evidenced by nuclear condensation, internucleosomal DNA fragmentation. Treatment of HepG2 cells with CSPC caused a loss of mitocho...
13 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Xiaoping Luo (Jiangsu University)H-Index: 7
Last.Yongsheng Yan (Jiangsu University)H-Index: 50
view all 7 authors...
An electrochemical molecularly imprinted polymer (MIP) sensor for detecting the existence of epigallocatechin-3-gallate (EGCG) in tea and its products was successfully developed on the basis of a glassy carbon electrode modified with an electropolymerized nonconducting poly(o-phenylenediamine) film. The properties of the electrode were characterized by cyclic voltammetry, differential pulse voltammetry, and infrared spectroscopy. The template molecules could be rapidly and thoroughly removed by ...
11 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 2
#2Zhigao Wang (Jiangsu University)H-Index: 2
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg−1 LSPCs treatment significantly increased body weight compared with the ELF-EMF group at ELF-EMF exposure and effectively maintained liver index, thymus index, kidney index and spleen index close to normal. A wa...
22 CitationsSource
12