Jun Yan
Peking University
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Publications 24
#1Liu SH-Index: 1
#2Li AH-Index: 1
Last. Liu BH-Index: 1
view all 26 authors...
Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated. Aims To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functi...
5 CitationsSource
#1Ang Li (CAS: Chinese Academy of Sciences)H-Index: 2
#2Andrew Zalesky (University of Melbourne)H-Index: 42
Last. Guangxiang Rao (CAS: Chinese Academy of Sciences)H-Index: 1
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Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia1–5. We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification, prognosis and subtyping based on functional striatal abnormalities (FSA). FSA scores provide a personalized index of striatal dysfunction, ranging from normal to highly pathological. Using inter-site cross-validation on functional magnetic resonance images acquired from seven independent scan...
4 CitationsSource
#1Weizheng Yan (CAS: Chinese Academy of Sciences)H-Index: 2
#2Vince D. CalhounH-Index: 93
Last. Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
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Abstract Background Current fMRI-based classification approaches mostly use functional connectivity or spatial maps as input, instead of exploring the dynamic time courses directly, which does not leverage the full temporal information. Methods Motivated by the ability of recurrent neural networks (RNN) in capturing dynamic information of time sequences, we propose a multi-scale RNN model, which enables classification between 558 schizophrenia and 542 healthy controls by using time courses of fM...
1 CitationsSource
#1Sangma Xie (Hangzhou Dianzi University)H-Index: 5
Last. Tianzi JiangH-Index: 67
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Abstract Auditory verbal hallucinations (AVH) are one of the cardinal symptoms of schizophrenia, and are proposed to be associated with altered integrity of the left perisylvian language pathways. There is considerable heterogeneity in the pattern of white matter abnormalities across previous studies. We investigated the white matter integrity of the perisylvian language pathways in schizophrenia patients with AVH based on a relatively large sample dataset from four different sites. 113 schizoph...
1 CitationsSource
#1Shengfeng LiuH-Index: 4
#2Haiying Wang (Harbin University of Science and Technology)H-Index: 1
Last. Jing SuiH-Index: 31
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Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such as schizophrenia (SZ). In this article, we aim to investigate the covarying abnormalities underlying SZ in a large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four types of magnetic resonance imaging (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) from structural MRI, fr...
5 CitationsSource
#1Jinmin Liao (PKU: Peking University)H-Index: 3
#2Tian Li (PKU: Peking University)
Last. Jun Yan (PKU: Peking University)H-Index: 9
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Abstract Functional neuroimaging studies by near-infrared spectroscopy (NIRS) have focused on the role of the prefrontal cortex (PFC) in the pathophysiology of obsessive-compulsive disorder (OCD). However, the reported areas in the PFC were inconsistent in OCD, and correlations between hemodynamic response and clinical symptoms have not been investigated. This study aimed to evaluate the hemodynamic response related to the verbal fluency task (VFT) and assess the relationship between activation ...
#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Jing SuiH-Index: 31
Last. Tianzi JiangH-Index: 67
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Abstract Background In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset. Methods Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-su...
3 CitationsSource
#1Linlin QiuH-Index: 2
#2Hao Yan (PKU: Peking University)H-Index: 79
Last. Dai Zhang (PKU: Peking University)H-Index: 28
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Widespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, the loss of gray matter density is specifically related to deficits of the responsive search score (RSS) of EEM in schizophrenia. It is unknown, however, whether the schizophrenia-related RSS deficits are associated with certain psychotic symptoms, such as hallucinat...
2 CitationsSource
#1Xiao Zhang (PKU: Peking University)H-Index: 2
#2Yuyanan Zhang (PKU: Peking University)H-Index: 1
Last. Hao Yan (PKU: Peking University)H-Index: 79
view all 8 authors...
Cross-sectional and longitudinal studies have identified widespread and progressive grey matter volume (GMV) reductions in schizophrenia, especially in the frontal lobe. In this study, we found a progressive GMV decrease in the rostral medial frontal cortex (rMFC, including the anterior cingulate cortex) in the patient group during a 6-week follow-up of 40 patients with schizophrenia and 31 healthy controls well-matched for age, gender, and education. The higher baseline GMV in the rMFC predicte...
2 CitationsSource
#1Jing Li (PKU: Peking University)
#2Hao YuH-Index: 11
Last. Hao YanH-Index: 13
view all 8 authors...
Objective To explore the effect of single nucleotide polymorphisms in CSMD1 on grey matter volume (GMV) and verbal fluency in schizophrenic patients. Methods Eighty-seven schizophrenic patients and 98 normal controls underwent MRI scanning, cognitive assessment and whole-genome genotyping. Linear regression model was conducted to explore the association between the genotype of CSMD1 and cognitive function (digit symbol substitution test (DSST) ,verbal fluency test (VFT) ) ; The full factorial an...