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Aybüke Olgun
Dokuz Eylül University
ImmunologyMultiple myelomaCisplatinOtotoxicityMedicine
9Publications
2H-index
21Citations
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Publications 10
Newest
#1Cihan AgalarH-Index: 4
Last. Tarkan UnekH-Index: 12
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Amac: Immun trombositopenik purpura (ITP), edinilmis trombositopeninin en sik nedenlerinden biridir. Immun trombositopenik purpura tanili hastalarin ikinci sira tedavisinde laparoskopik splenektomi (LS) yaygin olarak uygulanmaktadir. Bu calismanin amaci merkezimizde ITP nedeniyle LS uygulanan hastalarin peri-operatif ve uzun donem sonuclarini Vicenza konsensus kriterleri cercevesinde degerlendirmektir. Gerec ve Yontem: 2010-2017 yillari arasinda ITP tanisiyla merkezimizde LS uygulanan hastalarin...
#1Cihan AgalarH-Index: 4
#2Aybüke OlgunH-Index: 2
Last. Tarkan UnekH-Index: 12
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#2Celal AcarH-Index: 3
Last. Güner Hayri Özsan (Dokuz Eylül University)H-Index: 6
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BACKGROUND: Recent reports have showed that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are predictors of progression-free survival (PFS) and overall survival (OS) in many types of cancer. This study evaluates the predictive value of NLR, MLR, and PLR for survival in MM patients treated with to ASCT. METHODS: A set of data consisting of 150 patients who underwent autologous stem cell transplantation (ASCT) for MM was collected ...
Source
#1Omur Gokmen Sevindik (Fırat University)H-Index: 2
#2Mustafa Pehlivan (University of Gaziantep)H-Index: 14
Last. Güner Hayri Özsan (Dokuz Eylül University)H-Index: 6
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Introduction: Pomalidomide is a potent immunomodulatory drug (imid) with efficacy demonstrated in relapsed refractory multiple myeloma. In a phase 3 study, pomalidomide showed a benefit of PFS and OS over high dose dexamethasone, even in proteasome inhibitor and imid refractory patients. In our country, Pomalidomide has recently gained approval in relapsed refractory setting in patients who were both refractory to a proteasome inhibitor and an immunomodulatory drug. Before this approval we were ...
#1Aybüke OlgunH-Index: 2
#2Fatih DemirkanH-Index: 13
The aim of our study was to investigate the effects Korean Red Ginseng (KRG) on cisplatin (CDDP) ototoxicity in vivo and in vitro.The first part of the study was conducted on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cell line. Cells were treated with CDDP, KRG, and their combination for 24 h. Cell viability, apoptosis, and the expression of 84 apoptosis-related genes were analyzed. In the second part of the study, 30 Wistar albino rats were divided into five groups. Baseline distortion...
6 CitationsSource
#1Yüksel Olgun (Dokuz Eylül University)H-Index: 8
#2Günay Kirkim (Dokuz Eylül University)H-Index: 10
Last. Enis Alpin Güneri (Dokuz Eylül University)H-Index: 13
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Objectives/Hypothesis Our objectives were to study effects of orally administered resveratrol (RV) against cisplatin (CDDP) ototoxicity in different doses and to investigate ultrastructural changes in the cochlea and brainstem. Study Design In vivo study using an animal model. Methods Thirty-two male Wistar albino rats were divided into six groups. Baseline distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements were made. In groups I, II, and III, on...
14 CitationsSource
#1Ayfer ColakH-Index: 8
#2Burak ToprakH-Index: 5
Last. Safiye AktasH-Index: 12
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Source
#1Abdullah KatgiH-Index: 4
#2Aybüke OlgunH-Index: 2
Last. Bülent ÜndarH-Index: 11
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Amac: Follikuler lenfoma, ikinci en sik gorulen lenfoma turu olup, butun non hodgkin lenfomalarin %20-25’ini, yavas seyirli (indolen) lenfomalarin ise %70’ini olusturur. Ortalama yasam beklentisi yaklasik 10 yildir. Fakat beklenen yasam suresi monoklonal antikorlarin kesfi ile uzamistir. Yontemler: Bu calismada, follikuler lenfomali 28 hastanin klinikopatolojik ozellikleri, tedavi modaliteleri ve yanit oranlari retrospektif olarak degerlendirilmistir. Bulgular: Hastalarin %39,3’unde B semptomlar...
Source
#1Abdullah KatgiH-Index: 4
#2Aybüke OlgunH-Index: 2
Last. Bülent ÜndarH-Index: 11
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