Wai Tong Ng
Pamela Youde Nethersole Eastern Hospital
CancerPathologyNasopharyngeal carcinomaRadiation therapyMedicine
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Publications 128
#1Josephine Mun Yee Ko (HKU: University of Hong Kong)H-Index: 13
#2Vince Vardhanabhuti (HKU: University of Hong Kong)H-Index: 1
Last. Chung-Kong KwanH-Index: 1
view all 21 authors...
Nasopharyngeal carcinoma (NPC) is an important cancer in Hong Kong. We aim to utilise liquid biopsies for serial monitoring of disseminated NPC in patients to compare with PET-CT imaging in detection of minimal residual disease. Prospective serial monitoring of liquid biopsies was performed for 21 metastatic patients. Circulating tumour cell (CTC) enrichment and characterisation was performed using a sized-based microfluidics CTC chip, enumerating by immunofluorescence staining, and using target...
#1Luiz Paulo Kowalski (USP: University of São Paulo)H-Index: 2
#2Álvaro Sanabria (UdeA: University of Antioquia)H-Index: 20
Last. Carol R. Bradford (UM: University of Michigan)H-Index: 70
view all 22 authors...
The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that is spread human-to-human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities. There is an important risk of contagion for anesthetists, dentists, head and neck surgeons, maxillofacial surgeons, ophthalmologists and otolaryngologists. Healt...
15 CitationsSource
#1Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 27
#2June Corry (St. Vincent's Health System)H-Index: 37
Last. Robert SmeeH-Index: 20
view all 14 authors...
Abstract Up to one in four patients with nasopharyngeal carcinoma present with non-metastatic stage IV disease (i.e. T4 or N3). Distinct failure patterns exist, despite the routine adoption of contemporary treatment modalities such as intensity modulated radiotherapy and systemic chemotherapy. Concurrent chemoradiotherapy (CCRT) followed by adjuvant chemotherapy or induction chemotherapy followed by CCRT are commonly employed in this setting, with the latter emerging as the preferred option. Add...
#1Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 27
#2Michael Ch Lee (Pamela Youde Nethersole Eastern Hospital)
Last. Anne Wm Lee (HKU: University of Hong Kong)H-Index: 1
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BACKGROUND: This study analyzed the dose volume effects of re-irradiation for locally recurrent nasopharyngeal carcinoma (NPC) and attempts to determine the optimal dose for the best survival. METHODS: Ninety-one patients were studied. The local control, fatal complication, and overall survival were analyzed against the dose (in Equivalent Dose at 2 Gy/fractions) and recurrent gross tumor volume (GTV). RESULTS: The local control and fatal complication rate appear to increase with prescribed dose...
#1Nelson Tsz Cheong Fung (Pamela Youde Nethersole Eastern Hospital)H-Index: 1
#2Wai Man HungH-Index: 5
Last. Wai Tong NgH-Index: 27
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Abstract The aim of this study was to quantify the geometrical differences between manual contours and autocontours, the dosimetric impacts, and the time gain of using autosegmentation in adaptive nasopharyngeal carcinoma (NPC) intensity-modulated radiotherapy (IMRT) for a commercial system. A total of 20 consecutive Stages I to III NPC patients who had undergone adaptive radiation therapy (ART) re planning for IMRT treatment were retrospectively studied. Manually delineated organs at risks (OAR...
1 CitationsSource
#1Anne W.M. Lee (HKU: University of Hong Kong)H-Index: 35
#2Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 27
Last. Joseph Wee (NUS: National University of Singapore)H-Index: 31
view all 29 authors...
Abstract Purpose The treatment of nasopharyngeal carcinoma (NPC) requires high radiation doses. The balance of the risks of local recurrence due to inadequate tumor coverage versus the potential damage to the adjacent organs at risk (OARs) is of critical importance. With advancements in technology, high target conformality is possible. Nonetheless, to achieve the best possible dose distribution, optimal setting of dose targets and dose prioritization for tumor volumes and various OARs is fundame...
#1Anne W.M. Lee (HKU: University of Hong Kong)H-Index: 35
#2Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 27
Last. Alfio FerlitoH-Index: 58
view all 14 authors...
Abstract As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10–20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the poss...
1 CitationsSource
#1Luo Chen (Hong Kong Baptist University)
#2Lai Sheung Chan (Hong Kong Baptist University)H-Index: 1
Last. Nai-Ki Mak (Hong Kong Baptist University)H-Index: 28
view all 12 authors...
Abstract Background Sulforaphane (SFN), a natural compound present in cruciferous vegetable, has been shown to possess anti-cancer activities. Cancer stem cell (CSC) in bulk tumor is generally considered as treatment resistant cell and involved in cancer recurrence. The effects of SFN on nasopharyngeal carcinoma (NPC) CSCs have not yet been explored. Purpose The present study aims to examine the anti-tumor activities of SFN on NPC cells with CSC-like properties and the underlying mechanisms. Met...
1 CitationsSource
#1Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 27
#2Edwin C.Y. Wong (Pamela Youde Nethersole Eastern Hospital)H-Index: 2
Last. Kwok‐Hung AuH-Index: 1
view all 13 authors...
2 CitationsSource