Lisa Manuzzi
University of Bologna
Publications 11
Abstract Background Although prognosis of NENs is affected by several features including tumour burden, the specific role of this factor in pancreatic NENs (PanNENs) and gastrointestinal NENs (GI NENs) is not well established. Aim To compare the prognostic role of tumour burden in PanNENs and GI NENs. Patients and methods This study was a retrospective analysis of stage IV PanNENs and GI NENs. Tumours were classified based on liver tumour volume ( 25%). Overall survival as assessed by Kaplan-Mei...
#1Nicole BrighiH-Index: 6
#2Giuseppe LambertiH-Index: 3
Last.Davide CampanaH-Index: 25
view all 5 authors...
Typical (TC) and atypical (AC) carcinoids are low-grade neuroendocrine tumors (NETs) of the lung and, are neglected diseases in respect of both high-grade NETs of the lung (i.e. small-cell lung cancer and large-cell neuroendocrine carcinoma) and gastroenteropancreatic (GEP)-NETs. AC and TC account f
#1Ilaria Maggio (UNIBO: University of Bologna)H-Index: 2
#2V. Mollica (UNIBO: University of Bologna)
Last.Davide Campana (UNIBO: University of Bologna)H-Index: 25
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Purpose Insulinomas are a rare type of neuroendocrine tumors, originating in the pancreas, difficult to diagnose and to treat. Due to its rarity, insulinomas are a not well-known pathological entity; thus, the diagnostic process is frequently a medical challenge with many possible differential diagnoses. The diagnostic process varies between non-invasive procedures, such as the fasting test or imaging techniques, and invasive ones. Insulinomas are rarely malignant, but the glycemic imbalance cor...
#1Nicole Brighi (UNIBO: University of Bologna)H-Index: 6
#2Giuseppe Lamberti (UNIBO: University of Bologna)H-Index: 3
Last.Davide Campana (UNIBO: University of Bologna)H-Index: 25
view all 12 authors...
Abstract Background Somatostatin analogs are the backbone of neuroendocrine neoplasms treatment. Biliary stone disease is a potentially severe adverse event of somatostatin analogs: an increased incidence has been reported in somatostatin analogs-treated acromegalic patients, but studies on patients with neuroendocrine neoplasms are lacking. Aims To evaluate biliary stone disease incidence and associated factors in a large series of patients treated with somatostatin analogs for neuroendocrine n...
2 CitationsSource
#1Francesco PanzutoH-Index: 24
#2Davide Campana (UNIBO: University of Bologna)H-Index: 25
Last.Bruno Annibale (Sapienza University of Rome)H-Index: 48
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Abstract Background Gastric neuroendocrine neoplasias (gNEN) are defined as type I if associated with atrophic body gastritis and type III when tumour is sporadic. This classification, together with grading and size, plays a crucial prognostic role. Nevertheless, the impact of these features on clinical outcome is not clear. Aim To identify factors predicting poor outcome. Patients and methods Analysis of type I and type III gNEN. A composite endpoint was defined if tumour-related death or metas...
#1F. PanzutoH-Index: 4
#2Davide CampanaH-Index: 25
Last.Bruno AnnibaleH-Index: 48
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The mechanistic target of rapamycin (mTOR) is part of the phosphoinositide-3-kinase (PI3K)/protein kinase B (AkT)/mTOR pathway and owes its name to the inhibitory effect of rapamycin. The mTOR has a central converging role for many cell functions, serving as a sensor for extracellular signals from energy status and nutrients availability, growth factors, oxygen and stress. Thus, it also modulates switch to anabolic processes (protein and lipid synthesis) and autophagy, in order to regulate cell ...
6 CitationsSource
#1Maria RinzivilloH-Index: 9
#2Francesco PanzutoH-Index: 24
Last.Gianfranco Delle FaveH-Index: 53
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#1Simone Longhi (UNIBO: University of Bologna)H-Index: 16
#2Candida Cristina Quarta (UNIBO: University of Bologna)H-Index: 18
Last.Claudio Rapezzi (UNIBO: University of Bologna)H-Index: 49
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AbstractBackground: Although atrial fibrillation (AF) is a known complication of amyloidotic cardiomyopathy (AC), a precise pathophysiological and prognostic characterization is not available. We therefore aimed to assess prevalence, incidence, risk factors and prognostic significance of AF in light-chain (AL), hereditary transthyretin-related (m-ATTR) and non-mutant transthyretin-related (wt-ATTR) AC.Methods: Retrospective study of 262 patients with AC (123 AL, 94 m-ATTR, 45 wt-ATTR) from a sin...
22 CitationsSource