Hisahiko Sekihara
Yokohama City University
Publications 148
#1Yoshihiko Yamada (YCU: Yokohama City University)H-Index: 7
#2Hisahiko Sekihara (YCU: Yokohama City University)H-Index: 41
Last.Hajime Nawata (Kyushu University)H-Index: 26
view all 13 authors...
In man, serum concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease with age after the twenties. For this reason, the decline in DHEA and DHEAS concentrations may be related to the development of some chronic diseases that are prevalent in the older age population. In this study, we evaluate the benefit and safety level of DHEA administration to men as a hormone replacement therapy. Twenty-two healthy Japanese males (age 26-63; mean ± SD, 41.0 ± 10.0 yrs.) received 25...
12 CitationsSource
#1Satsuki Kawasaki (YCU: Yokohama City University)H-Index: 6
#2Osamu Hasegawa (Yokohama City University Medical Center)H-Index: 4
Last.Hisahiko Sekihara (YCU: Yokohama City University)H-Index: 41
view all 10 authors...
Objective: To examine factors that affect the development of retinopathy after short-term inpatient management of diabetes. Patients and Methods: The subjects were 143 patients with type 2 diabetes who were admitted for inpatient management of diabetes, and did not have retinopathy of the right eye at admission, and had an HbA1c level of ≥8.0%. We studied the characteristics of patients who developed retinopathy within one year after discharge. Results: Between the admission date and one year af...
5 CitationsSource
#1Hideyuki KayamaH-Index: 3
#2Masahiko InamoriH-Index: 35
Last.Hisahiko SekiharaH-Index: 41
view all 15 authors...
Background/Aims: Endoscopic injection sclerotherapy is in widespread use for patients with esophageal varices. It is well known that pleural effusions are among complications following endoscopic sclerotherapy. However, there are few studies regarding the proportion of patients developing pleural effusions after sclerotherapy. Methodology: Between August 1991 and September 1998, 575 endoscopic injection sclerotherapies were carried out in 128 patients. Chest radiographs were obtained prior to an...
4 Citations
#1Masahiko InamoriH-Index: 35
#2Takeshi ShimamuraH-Index: 39
Last.Shizuo TominagaH-Index: 5
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Background/Aims: Nitric oxide (NO) production is elevated in the intestine and may contribute to intestinal injury during inflammation. However, how the expression of inducible NO synthase (iNOS) mRNA and endothelial NO synthase (eNOS) mRNA in the esophageal mucosa contribute to mucosal damage caused by reflux esophagitis remains unknown. Since vascular endothelial growth factor (VEGF) exerts its action on microcirculation, contributing to angiogenesis and inflammation, we examined the role of V...
5 Citations
Dehydroepiandrosterone (DHEA) is a type of adrenal steroid. The concentrations of DHEA and its sulfate (DHEA-S) in serum reach a peak between the ages of 25 and 30 yr and thereafter decline steadily. It was reported that DHEA-S concentration in humans is inversely related to death from cardiovascular diseases. In this study, we examined the effects of DHEA on regulation of collagen mRNA and collagen synthesis in cultured cardiac fibroblasts. Treatment with DHEA (10−6 M) resulted in a significant...
23 CitationsSource
#1Takako Yoshii (YCU: Yokohama City University)H-Index: 1
#2Keiko Mizuno (YCU: Yokohama City University)H-Index: 31
Last.Shigeo Ohno (YCU: Yokohama City University)H-Index: 83
view all 6 authors...
PAR-3 (partitioning-defective) is a scaffold-like PDZ (postsynaptic density-95/discs large/zonula occludens-1) domain-containing protein that forms a complex with PAR-6 and atypical PKC, localizes to tight junctions, and contributes to the formation of functional tight junctions. There are several alternatively spliced isoforms of PAR-3, although their physiological significance remains unknown. In this study, we show that one of the major isoforms of PAR-3, sPAR-3, is predominantly expressed in...
5 CitationsSource
#1Ryo Yamashita (YCU: Yokohama City University)H-Index: 6
#2Tatsuya Saito (YCU: Yokohama City University)H-Index: 9
Last.Hisahiko Sekihara (YCU: Yokohama City University)H-Index: 41
view all 6 authors...
Dehydroepiandrosterone (DHEA), the most abundant human adrenal steroid, improves insulin sensitivity and obesity in human and model animals. In a previous study, we reported that orally administered DHEA suppresses the elevated activities of hepatic gluconeogenic enzymes like glucose-6-phosphatase (G6Pase) in C57BL/KsJ-db/db mice (Aoki K, Saito T, Satoh S, Mukasa K, Kaneshiro M, Kawasaki S, Okamura A, Sekihara H (1999) Diabetes 48: 1579-1585). However, the molecular mechanisms by which DHEA amel...
37 CitationsSource
#1Jun-Ichi TogawaH-Index: 6
#2Masahiko InamoriH-Index: 35
Last.Hisahiko SekiharaH-Index: 41
view all 14 authors...
Background/Aims: Triple therapy consisting of lansoprazole, amoxicillin, and clarithromycin (LAC regimen) is widely used to eradicate Helicobacter pylori in Japan. However, the need for appropriate treatment after failure of initial therapy to eradicate H. pylori has been increasing. We therefore assessed the efficacy of a combination of rabeprazole, amoxicillin, and faropenem for second-line eradication therapy. Methodology: The subjects were 116 patients positive for H. pylori infection. Patie...
5 Citations
#1Yoji NagashimaH-Index: 2
#2Ichiro AokiH-Index: 1
Last.Eiji GotoH-Index: 2
view all 11 authors...
#1Masato Yoneda (YCU: Yokohama City University)H-Index: 35
#2Koichiro Wada (Osaka University)H-Index: 38
Last.Atsushi Nakajima (YCU: Yokohama City University)H-Index: 60
view all 11 authors...
Dehydroepiandrosterone (DHEA), one of the major androgens secreted by the adrenal cortex, has been shown to have potential immunoreguratory properties. In this study, we examined the effect of DHEA in a mouse model of hepatitis. Mice were treated with DHEA and injected with concanavalin A (Con A) or lipopolysaccharide (LPS)/D-galactosamine (GalN). Cytokine expression was measured by quantitative RT-PCR and ELISA. Apoptosis was detected by the TUNEL method and by DNA fragmentation analysis. In th...
10 CitationsSource