Elena Bolzacchini
Ospedale di Circolo e Fondazione Macchi
PathologyOncologyColorectal cancerGeneral surgeryMedicine
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Publications 22
Abstract Background Preliminary studies suggested that selected drug-related toxicities of sunitinib may correlate with a better prognosis. Patients and methods From January 2006 till December 2015 we retrospectively analysed data of 145 patients (pts) affected with metastatic renal cell carcinoma (mRCC) treated with sunitinib as a first-line therapy in 7 different Italian Oncology Departments. Hypertension, hypothyroidism, thrombocytopenia, neutropenia and anemia were evaluated. Overall surviva...
#1O. NigroH-Index: 1
Last. Graziella PinottiH-Index: 28
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Abstract Background Immunotherapy has become a standard of care for an increasing number of tumors. Patients have a chance of developing immune-related adverse events (irAEs). In general, irAEs occur quite early, mostly within weeks to 3 months after initiation of treatment. Being drugs relatively innovative, “late” irAEs are still unknown. Methods We conducted a multicenter retrospective study of advanced cancer patients (any histology, regardless of treatment line) treated with anti-PD-1/PD-L1...
#1Elena BolzacchiniH-Index: 2
Last. Carlo CapellaH-Index: 67
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Colorectal rhabdoid carcinomas (CRbCs) are very rare and aggressive cancers. The BRAF mutation and CpG island methylator phenotype have been reported to be common features of CRbCs. This study reviews the literature about CRbCs and analyzes the clinicopathological and molecular profiles of seven CRbCs characterized by large discohesive cells with abundant eosinophilic cytoplasm, showing hyaline inclusions and large rounded to bean-shaped nuclei. For comparison, we included four poorly differenti...
#1Elena BolzacchiniH-Index: 2
#2Giovanna LuchenaH-Index: 4
Last. Monica GiordanoH-Index: 18
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#1Nunzio Digiacomo (University of Insubria)H-Index: 2
#2Elena BolzacchiniH-Index: 2
Last. Daniela Furlan (University of Insubria)H-Index: 25
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Abstract Background Approximately 10% of metastatic colorectal cancer (mCRC) cases will harbor the BRAF p.V600E mutation (BRAF-mCRC) and have been associated with a poor prognosis. Although they are usually considered a unique clinical entity, biologic heterogeneity has been described. We performed an extensive clinicopathologic study of a multicenter series of BRAF-mCRC to highlight differences between tumors with microsatellite instability (MSI) and microsatellite stable tumors, focusing on bo...
2 CitationsSource
#1Francesca Spada (IEO: European Institute of Oncology)H-Index: 11
#2Massimo MilioneH-Index: 25
Last. Nicola Fazio (IEO: European Institute of Oncology)H-Index: 31
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e15695Background: Mixed adeno-neuroendocrine carcinomas (MANECs) are very rare malignancies. Due to their biological and clinical heterogeneity, there is not a universally shared clinical approach....
#1Elena BolzacchiniH-Index: 2
#2Alessandro TuziH-Index: 2
Last. Graziella PinottiH-Index: 28
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#1Elena BolzacchiniH-Index: 2
#2Roberta Cerutti (University of Insubria)H-Index: 13
Last. Daniela Furlan (University of Insubria)H-Index: 25
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e15624Background: BRAFV600E mutation occurs in less than 10% of colorectal cancers (BmutCRCs) and is a strong predictor of poor prognosis not only in metastatic setting. Although BmutCRCs are usual...
#1Elena BolzacchiniH-Index: 2
#2Claudio ChiniH-Index: 7
Last. Silvia Uccella (University of Insubria)H-Index: 22
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A 37-year-old male with long-standing and extensive ulcerative pancolitis developed a rapidly lethal poorly differentiated neuroendocrine carcinoma (NEC) in the sigmoid colon. Prior biopsies obtained from multiple sites of the colon during endoscopic surveillance showed minimal inflammatory changes and no sign of dysplasia. Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal malignancies, and adenocarcinoma is the most common type of colorectal neoplasm associated ...
1 CitationsSource