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I. Gushchin
Moscow Institute of Physics and Technology
BiophysicsMembrane proteinChemistryBacteriorhodopsinBiochemistry
49Publications
10H-index
370Citations
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Publications 68
Newest
#1I. GushchinH-Index: 10
#2Igor MelnikovH-Index: 4
Last. Valentin I. GordeliyH-Index: 23
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#1K. KovalevH-Index: 5
#2Roman Astashkin (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Antoine Royant (CNRS: Centre national de la recherche scientifique)H-Index: 18
view all 24 authors...
The light-driven sodium-pumping rhodopsin KR2 from Krokinobacter eikastus is the only non-proton cation active transporter with demonstrated potential for optogenetics. However, the existing structural data on KR2 correspond exclusively to its ground state, and show no sodium inside the protein, which hampers the understanding of sodium-pumping mechanism. Here we present crystal structure of the O-intermediate of the physiologically relevant pentameric form of KR2 at the resolution of 2.1 A, rev...
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#1I. Gushchin (MIPT: Moscow Institute of Physics and Technology)H-Index: 10
#2Philipp S. Orekhov (MIPT: Moscow Institute of Physics and Technology)H-Index: 4
Last. Valentin I. GordeliyH-Index: 23
view all 6 authors...
Membrane-embedded sensor histidine kinases (HKs) and chemoreceptors are used ubiquitously by bacteria and archaea to percept the environment, and are often crucial for their survival and pathogenicity. The proteins can transmit the signal from the sensor domain to the catalytic kinase domain reliably over the span of several hundreds of angstroms, and regulate the activity of the cognate response regulator proteins, with which they form two-component signaling systems (TCSs). Several mechanisms ...
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Last. I. GushchinH-Index: 10
view all 5 authors...
Source
#1K. KovalevH-Index: 5
#2I. GushchinH-Index: 10
Last. Valentin I. GordeliyH-Index: 23
view all 3 authors...
Source
#1K. KovalevH-Index: 5
Last. Valentin I. GordeliyH-Index: 23
view all 3 authors...
Source
#1K. KovalevH-Index: 5
#2I. GushchinH-Index: 10
Last. Valentin I. GordeliyH-Index: 23
view all 3 authors...
Source
#1A. RemeevaH-Index: 3
Last. Mehdi D. DavariH-Index: 10
view all 12 authors...
Light-oxygen-voltage (LOV) domains are ubiquitous photosensory modules found in proteins from bacteria, archaea and eukaryotes. Engineered versions of LOV domains have found widespread use in fluorescence microscopy and optogenetics, with improved versions being continuously developed. Many of the engineering efforts focused on the thermal stabilization of LOV domains. Recently, we described a naturally thermostable LOV domain from Chloroflexus aggregans. Here we show that the discovered protein...
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Membrane lipids are inherently highly dynamic molecules. Currently, it is difficult to probe the structures of individual lipids experimentally at the timescales corresponding to atomic motions, and consequently molecular dynamics simulations are used widely. In our previous work, we have introduced the principal component analysis (PCA) as a convenient framework for comprehensive quantitative description of lipid motions. Here, we present a newly developed open source script, PCAlipids, which a...
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#1K. KovalevH-Index: 5
#2Dimitij Volkov (Forschungszentrum Jülich)H-Index: 1
Last. A. V. Rogachev (JINR: Joint Institute for Nuclear Research)H-Index: 7
view all 18 authors...
Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), has recently been discovered. Unlike in the known rhodopsins, in HeRs the N termini face the cytoplasm. The function of HeRs remains unknown. We present the structures of the bacterial HeR-48C12 in two states at the resolution of 1.5 A, which highlight its remarkable difference from all known rhodopsins. The interior of HeR’s extracellular part is completely hydrophobic, while the cyto...
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