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Liang Guo
University of Michigan
6Publications
5H-index
69Citations
Publications 6
Newest
#1Xuelian Xiong (Fudan University)H-Index: 3
#2Henry Kuang (UM: University of Michigan)H-Index: 2
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 30 authors...
Summary Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex organs. Despite this, the global landscape of intercellular signaling in mammalian liver has not been elucidated. Here we perform single-cell RNA sequencing on non-parenchymal cells isolated from healthy and NASH mouse livers. Secretome gene analysis revealed a highly connected network of intrahepatic signaling and disruption of vascular signaling in NASH. We uncovered the emergence of NASH-associat...
#1Xuelian Xiong (Fudan University)H-Index: 3
#2Qiuyu Wang (UM: University of Michigan)H-Index: 2
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 8 authors...
Abstract Objective Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. The objectives of the current study are to delineate the transcriptomic and proteomic signatures of NASH liver, to identify potential pathogenic pathways and factors, and to critically assess their role in...
#1Qiuyu Wang (UM: University of Michigan)H-Index: 2
#2Vishal Premdev Sharma (UM: University of Michigan)H-Index: 4
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 13 authors...
Thermogenesis is an important contributor to whole-body energy expenditure and metabolic homeostasis. Although circulating factors that promote energy expenditure are known, endocrine molecules that suppress energy expenditure have remained largely elusive. Here we found that Tsukushi (TSK) is a liver-enriched secreted factor that is highly inducible in response to increased energy expenditure. Hepatic Tsk expression and plasma TSK levels were elevated in obesity. In mice, TSK deficiency increas...
#1Xu-Yun Zhao (UM: University of Michigan)H-Index: 2
#2Xuelian Xiong (Fudan University)H-Index: 3
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 10 authors...
Hepatic lipogenesis is aberrantly induced in nonalcoholic fatty liver disease (NAFLD) via activation of the LXR-SREBP1c pathway. To date, a number of protein factors impinging on the transcriptional activity of LXR and SREBP1c have been elucidated. However, whether this regulatory axis interfaces with long noncoding RNAs (lncRNAs) remains largely unexplored. Here we show that hepatic expression of the lncRNA Blnc1 is strongly elevated in obesity and NAFLD in mice. Blnc1 is required for the induc...
#1Liang Guo (Fudan University)H-Index: 5
#2Peng Zhang (UM: University of Michigan)H-Index: 6
Last.Jiandie D. Lin (Life Sciences Institute)H-Index: 38
view all 9 authors...
#1Zhimin Chen (UM: University of Michigan)H-Index: 4
#2Guo Xiao Wang (UM: University of Michigan)H-Index: 8
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 14 authors...
Abstract Objective Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induced metabolic disorders, including insulin resistance and hepatic steatosis. However, the physiological mechanisms through which Nrg4 regulates energy balance and glucose and lipid metabolism remain incompletely understood. The aims of the cur...
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