Alexis Régent
Paris Descartes University
PathologyPhysical therapyImmunologyGiant cell arteritisMedicine
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Publications 58
#1B. Terrier (Paris V: Paris Descartes University)H-Index: 3
#2Agnes Dechartres (University of Paris)H-Index: 25
Last. Loïc Guillevin (Paris V: Paris Descartes University)H-Index: 94
view all 14 authors...
BACKGROUND: Myocardial involvement may occur during systemic sclerosis (SSc) and lead to impaired myocardial contraction and/or arrhythmia. Cardiac magnetic resonance imaging (CMRI) is used for noninvasive characterization of myocardium. We aimed to evaluate the interest of CMRI with intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and T1 mapping to assess myocardial microvascular and interstitium impairment in SSc. PATIENTS AND METHODS: Single-center prospective study of 40 ...
#1J. BertolinoH-Index: 1
#2Elisabeth JouveH-Index: 16
Last. Benjamin ChaigneH-Index: 4
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Objective:Systemic sclerosis mainly affects the microvascular network. However, macrovascular manifestations have been reported. We aimed to investigate the characteristics of systemic sclerosis pa...
#1Yann Nguyen (Paris V: Paris Descartes University)H-Index: 1
#2Christian Pagnoux (MSH: Mount Sinai Hospital, Toronto)H-Index: 32
Last. Alexis Régent (Paris V: Paris Descartes University)H-Index: 12
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Abstract Objective To describe characteristics and long-term outcomes of patients with microscopic polyangiitis (MPA), an antineutrophil cytoplasm antibody (ANCA)-associated small-vessel necrotizing vasculitis. Methods MPA patients from the French Vasculitis Study Group Registry satisfying the European Medicines Agency algorithm were analyzed retrospectively. Characteristics at diagnosis, treatments, relapses and deaths were analyzed to identify factors predictive of death or relapse. Results Be...
#1C. Rodriguez-Régent (French Institute of Health and Medical Research)H-Index: 9
#2Wagih Ben Hassen (French Institute of Health and Medical Research)H-Index: 6
Last. Alexis Régent (Paris V: Paris Descartes University)H-Index: 12
view all 5 authors...
OBJECTIVES: Imaging techniques have an increasing place in the diagnosis of giant cell arteritis (GCA). Achieving a confident diagnosis of GCA is often challenging and temporal artery biopsy is still considered as the gold standard despite the delayed results. 3T-MRI with 2D sequences has been evaluated for the detection of mural inflammation in extracranial arteries to support the diagnosis of GCA. METHODS: We evaluated the diagnostic performance of fat-suppressed 3D T1-weighted black-blood MRI...
#2B. Dunogué (Paris V: Paris Descartes University)H-Index: 12
Last. Christian Roux (Paris V: Paris Descartes University)H-Index: 75
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OBJECTIVE Sarcopenia has been associated with poor outcomes in various medical and surgical conditions. However, its impact in systemic necrotizing vasculitides (SNV) had never been characterized. We aimed to assess the prevalence, associated factors and prognostic impact of sarcopenia in SNV. METHODS Patients with SNV were successively included in a prospective longitudinal study assessing comorbidities. At inclusion, we evaluated sarcopenia by assessing skeletal muscle mass index using DXA and...
#1Benjamin Chaigne (French Institute of Health and Medical Research)
#1Benjamin ChaigneH-Index: 4
Last. Luc Mouthon (CNRS: Centre national de la recherche scientifique)H-Index: 34
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Abstract Introduction Little is known about systemic sclerosis (SSc)-associated myopathy (SScAM) treatment. Herein we evaluated the use of intravenous immunoglobulin (IVIg) in SScAM. Methods We conducted a retrospective study of patients with SScAM in the Internal medicine department of Cochin University Hospital between 1993 and 2017. Results Fifty-two patients were included comprising 18 (34.6%) with limited SSc and 34 (65.4%) with diffuse SSc. SScAM occurred at a median [interquartile range (...
#1Cléa Melenotte (AMU: Aix-Marseille University)H-Index: 8
#2Julie Seguier (AMU: Aix-Marseille University)H-Index: 2
Last. Nicolas Schleinitz (AMU: Aix-Marseille University)H-Index: 28
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Abstract Pachymeningitis is rare, either idiopathic or secondary to inflammatory disorders, after tumoral, surgical or infectious causes have been excluded. The fibroinflammatory IgG4-related disease is one of the etiologies of pachymeningitis with only few cases reported yet. From a single referral regional center, we evaluated the frequency of IgG4-related disease as the cause of inflammatory pachymeningitis in 10% of cases. From a National case registry of IgG4-related disease the pachymening...
2 CitationsSource
#2W. Ben HassenH-Index: 6
Last. Alexis RégentH-Index: 12
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Introduction L’arterite a cellules geantes (ACG) est la plus frequente des vascularites des gros vaisseaux chez les patients de plus de 50 ans. La biopsie de l’artere temporale (BAT) est toujours consideree comme le gold standard pour le diagnostic d’ACG, mais elle est invasive et sa sensibilite varie de 39 a 86 %. L’echographie Doppler couleur et le PET-scanner ont ete proposes comme methodes alternatives de diagnostic d’une ACG mais leur usage n’est pas repandu en routine. Des recommandations ...
#1Alexis Régent (Paris V: Paris Descartes University)H-Index: 12
#2Kim Heang LyH-Index: 14
Last. Luc Mouthon (Paris V: Paris Descartes University)H-Index: 61
view all 3 authors...
Points cles L’arterite a cellules geantes (ACG) est une vascularite des vaisseaux de gros calibre interessant l’aorte et ses principales branches en particulier celles a destinee cerebrale. Bien que de gros progres aient ete faits, la physiopathologie reste incompletement elucidee. Un trigger initial, suspecte d’origine infectieuse, va conduire a la maturation et au recrutement de cellules dendritiques (DC). Le defaut de migration de ces DC va permettre le recrutement local de lymphocytes T (LT)...