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Xianghua Yan
Huazhong Agricultural University
23Publications
10H-index
7,283Citations
Publications 24
Newest
Early-weaning of piglets is often accompanied by severe disorders, especially diarrhea. The gut microbiota and its metabolites play a critical role in the maintenance of the physiologic and metabolic homeostasis of the host. Our previous studies have demonstrated that oral administration of Lactobacillus frumenti improves epithelial barrier functions and confers diarrhea resistance in early-weaned piglets. However, the metabolic response to L. frumenti administration remains unclear. Then, we co...
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#1Yangfan NieH-Index: 4
#2Jun HuH-Index: 6
Last.Xianghua YanH-Index: 10
view all 8 authors...
Oxidative damages have adverse effects on mammals. Growing studies have focused on exploring new antioxidants. Here, we report that Lactobacillus frumenti increases the total antioxidation capacity...
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#1Xiu-zhi Li (HAU: Huazhong Agricultural University)
#2Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to various environmental inputs, especially amino acids. In fact, the activity of mTORC1 is highly sensitive to changes in amino acid levels. Over past decades, a variety of proteins have been identified as participating in the mTORC1 pathway regulated by amino acids. Classically, the Rag guanosine triphosphatases (GTPases), which reside on the lysosome, transmit amino acid availability to the ...
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#1Jun Hu (HAU: Huazhong Agricultural University)H-Index: 6
#2Libao Ma (HAU: Huazhong Agricultural University)H-Index: 2
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 5 authors...
Intestinal microbial interactions with the host epithelium have important roles in host health. Our previous data have suggested that Lactobacillus gasseri LA39 is the predominant intestinal Lactobacillus in weaned piglets. However, the regulatory role of L. gasseri LA39 in the intestinal epithelial protein expression in piglets remains unclear. In the present study, we conducted comparative proteomics approach to investigate the intestinal epithelial protein profile alteration caused by L. gass...
1 CitationsSource
#1Jun Hu (HAU: Huazhong Agricultural University)H-Index: 6
#2Libao Ma (HAU: Huazhong Agricultural University)H-Index: 2
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 19 authors...
Summary Alternatives to antibiotics for preventing diarrhea in early-weaned farm animals are sorely needed. CM piglets (a native Chinese breed) are more resistant to early-weaning stress-induced diarrhea than the commercial crossbred LY piglets. Transferring fecal microbiota, but not saline, from healthy CM into LY piglets by oral administration prior to early weaning conferred diarrhea resistance. By comparing the relative abundance of intestinal microbiota in saline and microbiota transferred ...
5 CitationsSource
#1Jun Hu (HAU: Huazhong Agricultural University)H-Index: 6
#2Lingli Chen (HAU: Huazhong Agricultural University)H-Index: 3
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 16 authors...
The intestine of pigs harbors a mass of microorganisms which are essential for intestinal homeostasis and host health. Intestinal microbial disorders induce enteric inflammation and metabolic dysfunction, thereby causing adverse effects on the growth and health of pigs. In the human medicine, fecal microbiota transplantation (FMT), which engrafts the fecal microbiota from a healthy donor into a patient recipient, has shown efficacy in intestinal microbiota restoration. In addition, it has been u...
3 CitationsSource
#1Jun Hu (HAU: Huazhong Agricultural University)H-Index: 6
#2Lingli Chen (HAU: Huazhong Agricultural University)H-Index: 3
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 17 authors...
Increased intestinal epithelial barrier function damages caused by early weaning stress have adverse effects on swine health and feed utilization efficiency. Probiotics have emerged as the promising antibiotic alternatives used for intestinal barrier function damage prevention. Our previous data showed that Lactobacillus frumenti was identified as a predominant Lactobacillus in the intestinal microbiota of weaned piglets. However, whether the intestinal epithelial barrier function in piglets was...
11 CitationsSource
#1Guokai Yan (HAU: Huazhong Agricultural University)H-Index: 4
#2Xiuzhi Li (HAU: Huazhong Agricultural University)H-Index: 3
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 10 authors...
Leucine (Leu) is a multifunctional essential amino acid that plays crucial role in various cellular processes. However, the integral effect of Leu on the hepatic proteome remains largely unknown. Here, we for the first time applied an isobaric tags for relative and absolute quantification (iTRAQ)-based comparative proteomics strategy to investigate the proteome alteration induced by Leu deprivation in human hepatocellular carcinoma (HepG2) cells. A total of 4,111 proteins were quantified; 43 pro...
2 CitationsSource
#1Jun Hu (HAU: Huazhong Agricultural University)H-Index: 6
#2Yangfan Nie (HAU: Huazhong Agricultural University)H-Index: 4
Last.Xianghua Yan (HAU: Huazhong Agricultural University)H-Index: 10
view all 10 authors...
Abstract Leucine serves not only as a substrate for protein synthesis, but also as a signal molecule involved in protein metabolism. However, whether the levels of cellular reactive oxygen species (ROS), which have damaging effects on cellular DNA, proteins, and lipids, are regulated by leucine is still unclear. Here, we report that leucine supplementation reduces ROS levels in intestinal epithelial cells of weaned piglets. A proteomics analysis revealed that leucine supplementation induces an e...
7 CitationsSource
#1Qiwen FanH-Index: 5
#2Baisheng LongH-Index: 4
Last.Xianghua YanH-Index: 10
view all 11 authors...
2 CitationsSource
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