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Ting Zhuang
Karolinska Institutet
GeneKinaseCancer researchBreast cancerBiology
8Publications
4H-index
95Citations
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Publications 8
Newest
#1Tânia D. F. Costa (KI: Karolinska Institutet)H-Index: 2
#2Ting Zhuang (KI: Karolinska Institutet)H-Index: 4
Last. Staffan Strömblad (KI: Karolinska Institutet)H-Index: 30
view all 22 authors...
Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. Importantly, PAK4 prevents senescence-like growth arrest in breast cancer cells in vitro, in vivo and ex vivo, but is not needed in non-immortali...
3 CitationsSource
#1Parisa Rabieifar (KI: Karolinska Institutet)H-Index: 1
#2Ting Zhuang (KI: Karolinska Institutet)H-Index: 4
Last. Staffan Strömblad (KI: Karolinska Institutet)H-Index: 30
view all 5 authors...
p21-activated protein kinases (PAKs) are serine/threonine kinases functioning as downstream effectors of the small GTPases Rac1 and Cdc42. Members of the PAK family are overexpressed in human breast cancer, but their role in mammary gland development is not fully explored. Here we examined the functional role of PAK4 in mammary gland development by creating a mouse model of MMTV-Cre driven conditional PAK4 gene depletion in the mammary gland. The PAK4 conditional knock-out mice were born healthy...
1 CitationsSource
#1Miao Zhao (KI: Karolinska Institutet)H-Index: 2
#2Parisa Rabieifar (KI: Karolinska Institutet)H-Index: 1
Last. Staffan Strömblad (KI: Karolinska Institutet)H-Index: 30
view all 8 authors...
Constitutive depletion of p21-activated kinase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defects. Given that conventional gene depletion of PAK1 or PAK3 caused functional deficits in the mouse pancreas, while gene depletion of PAK5 or PAK6 did not, we asked if PAK4 might have a functional role in pancreas development. We therefore introduced conditional, Pdx1-Cre-mediated, pancreatic PAK4 gene depletion in the mouse, verified by loss of PAK4 protein express...
3 CitationsSource
#1Jian Zhu (KI: Karolinska Institutet)H-Index: 5
#2Chunyan Zhao (KI: Karolinska Institutet)H-Index: 26
Last. Karin Dahlman-Wright (KI: Karolinska Institutet)H-Index: 43
view all 8 authors...
The atypical E3 ubiquitin ligase RNF31 is highly expressed in human breast cancer, the most frequent neoplastic lethality among women. Here, RNF31 depletion in breast cancer cells in combination with global gene expression profiling revealed p53 (TP53) signaling as a potential RNF31 target. Interestingly, RNF31 decreased p53 stability, whereas depletion of RNF31 in breast cancer cells caused cell cycle arrest and cisplatin-induced apoptosis in a p53-dependent manner. Furthermore, RNF31 associate...
16 CitationsSource
#1Ting ZhuangH-Index: 4
#2Jian ZhuH-Index: 5
Last. Staffan StrömbladH-Index: 30
view all 7 authors...
// Ting Zhuang 1, * , Jian Zhu 1, * , Zhilun Li 1 , Julie Lorent 2 , Chunyan Zhao 1 , Karin Dahlman-Wright 1, 3 , Staffan Stromblad 1 1 Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden 2 Department of Oncology and Pathology, Karolinska Institutet, Solna, Sweden 3 Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Solna, Sweden * These authors have contributed equally to this work Correspondence to: Staffan Stromblad, e-mail: staffan.stromblad@...
19 CitationsSource
#1Miao Zhao (KI: Karolinska Institutet)H-Index: 2
#2Tânia D. F. Costa (KI: Karolinska Institutet)H-Index: 1
Last. Staffan Strömbald (KI: Karolinska Institutet)
view all 6 authors...
Source
#1Yichun QiaoH-Index: 5
#2Chiou-Nan ShiueH-Index: 5
Last. Karin Dahlman-WrightH-Index: 43
view all 8 authors...
// Yichun Qiao 1 , Chiou-Nan Shiue 2, 3 , Jian Zhu 1 , Ting Zhuang 1 , Philip Jonsson 4 , Anthony P.H. Wright 2 , Chunyan Zhao 1 , Karin Dahlman-Wright 1, 5 1 Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden 2 Clinical Research Center (KFC), Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden 3 Department of Pediatrics, Hualien Tzu Chi Hospital, Buddist Tzu Chi Medical Foundation, Hualien, Taiwan 4 Center for Nuclear Receptors and Cel...
23 CitationsSource
#1Jian Zhu (KI: Karolinska Institutet)H-Index: 5
#2Chunyan Zhao (KI: Karolinska Institutet)H-Index: 26
Last. Karin Dahlman-Wright (KI: Karolinska Institutet)H-Index: 43
view all 13 authors...
Estrogen receptor α (ERα) is initially expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression by regulating the transcription of genes linked to cell proliferation. ERα status is of clinical importance, as ERα-positive breast cancers can be successfully treated by adjuvant therapy with antiestrogens or aromatase inhibitors. Complications arise from the frequent development of drug resistance that might be caused by multiple alterations, including component...
32 CitationsSource
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