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Ying Li
Oregon National Primate Research Center
27Publications
14H-index
1,455Citations
Publications 27
Newest
Published on Mar 1, 2019in Journal of Computer Science and Technology 0.88
Zhiguo Wan16
Estimated H-index: 16
(SDU: Shandong University),
Robert H. Deng48
Estimated H-index: 48
(Singapore Management University)
+ 1 AuthorsYing Li14
Estimated H-index: 14
While Bitcoin gains increasing popularity in different payment scenarios, the transaction fees make it difficult to be applied to micropayment. Given the wide applicability of micropayment, it is crucial for all cryptocurrencies including Bitcoin to provide effective support therein. In light of this, a number of low-cost micropayment schemes for Bitcoin have been proposed recently to reduce micropayment costs. Existing schemes, however, suffer from drawbacks such as high computation cost, infle...
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Published on Mar 1, 2019in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
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Published on Jul 24, 2018in PLOS ONE 2.77
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
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Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Jan 1, 2017in Cell Stem Cell 23.29
Hong Ma27
Estimated H-index: 27
(OHSU: Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(UCSD: University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
21 Citations Source Cite
Published on Dec 1, 2016in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(UOU: University of Ulsan),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
70 Citations Source Cite
Published on Aug 1, 2016in Cell Metabolism 20.57
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti Gutierrez10
Estimated H-index: 10
(Oregon National Primate Research Center)
+ 9 AuthorsDon P. Wolf42
Estimated H-index: 42
(Oregon National Primate Research Center)
Vertebrate cells carry two different genomes, nuclear (nDNA) and mitochondrial (mtDNA), both encoding proteins involved in oxidative phosphorylation. Because of the extensive interactions, adaptive coevolution of the two genomes must occur to ensure normal mitochondrial function. To investigate whether incompatibilities between these two genomes could contribute to interspecies reproductive barriers, we performed reciprocal mtDNA replacement (MR) in zygotes between widely divergent Mus m. domest...
30 Citations Source Cite
Published on Jul 1, 2016in Protein & Cell 6.23
Ying Li14
Estimated H-index: 14
(CAS: Chinese Academy of Sciences),
Weizhou Zhang25
Estimated H-index: 25
(UI: University of Iowa)
+ 13 AuthorsYanxia Ye2
Estimated H-index: 2
(CAS: Chinese Academy of Sciences)
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based on a screen of a number of chemicals, here we found that Vitamin C exerts most efficient rescue for many features in premature aging as shown in WRN-deficient MSCs, including cell growth arrest, increased reactive oxygen species...
19 Citations Source Cite
Published on May 1, 2016in Cell Stem Cell 23.29
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Xinjian Wang20
Estimated H-index: 20
(Cincinnati Children's Hospital Medical Center)
+ 20 AuthorsYing Li14
Estimated H-index: 14
(Oregon National Primate Research Center)
Summary The genetic integrity of iPSCs is an important consideration for therapeutic application. In this study, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblasts, blood, and iPSCs derived from young and elderly subjects (24–72 years). We found that pooled skin and blood mtDNA contained low heteroplasmic point mutations, but a panel of ten individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load of heteroplas...
76 Citations Source Cite
Published on Feb 1, 2016in Cell Research 15.39
Huize Pan6
Estimated H-index: 6
,
Di Guan3
Estimated H-index: 3
+ 19 AuthorsWeiqi Zhang17
Estimated H-index: 17
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues. To this end, we generated SIRT6 knockout human mesenchymal stem cells (hMSCs) by targeted gene editing. SIRT6-deficient hMSCs exhibited accelerated functional decay, a feature distinct from typical premature c...
72 Citations Source Cite
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