Match!
Pascale Krejbich-Trotot
University of La Réunion
18Publications
10H-index
573Citations
Publications 18
Newest
#1Jonathan TurpinH-Index: 2
#2Etienne FrumenceH-Index: 3
Last.Pascale Krejbich-TrototH-Index: 10
view all 5 authors...
Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction of cell death. However, previous studies suggest that the virally induced apoptosis occurs at a slower rate compared to the course of viral production. In this present study, we investigated the capacity of ZIKV to delay host cell apoptosis. We provide evidence...
Source
#1Jonathan TurpinH-Index: 2
#2Etienne FrumenceH-Index: 3
Last.Wildriss ViranaickenH-Index: 8
view all 7 authors...
Source
#1Sandra BosH-Index: 5
Last.Gilles GadeaH-Index: 17
view all 8 authors...
Source
#2Etienne FrumenceH-Index: 3
Last.Wildriss ViranaickenH-Index: 8
view all 12 authors...
Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA repl...
5 CitationsSource
#1Elodie Clain (University of La Réunion)H-Index: 3
#2Laura Sinigaglia (Pasteur Institute)H-Index: 4
Last.Chaker El Kalamouni (University of La Réunion)H-Index: 4
view all 13 authors...
The mosquito-borne Zika virus (ZIKV) belongs to the flavivirus genus of the Flaviviridae family. Contemporary epidemic strains of ZIKV are associated with congenital malformations in infants, including microcephaly, as well as Guillain-Barre syndrome in adults. A risk of human-to-human transmission of ZIKV is also well documented. A worldwide research effort has been undertaken to identify safe and effective strategies to prevent or treat ZIKV infection. We show here that extract from Aphloia th...
6 CitationsSource
#1Arnaud Gaudry ('ENS Paris': École Normale Supérieure)H-Index: 2
#2Sandra BosH-Index: 5
Last.Chaker El-KalamouniH-Index: 4
view all 8 authors...
The medical importance of Zika virus (ZIKV) was fully highlighted during the recent epidemics in South Pacific islands and Americas due to ZIKV association with severe damage to fetal brain development and neurological complications in adult patients. A worldwide research effort has been undertaken to identify effective compounds to prevent or treat ZIKV infection. Fruits and vegetables may be sources of compounds with medicinal properties. Flavonoids are one class of plant compounds that emerge...
12 CitationsSource
#1Sandra Bos (University of La Réunion)H-Index: 5
#2Wildriss Viranaicken (University of La Réunion)H-Index: 8
Last.Gilles Gadea (University of La Réunion)H-Index: 17
view all 8 authors...
Abstract Mosquito-borne Zika virus (ZIKV) recently emerged in South Pacific islands and Americas where large epidemics were documented. In the present study, we investigated the contribution of the structural proteins C, prM and E in the permissiveness of human host cells to epidemic strains of ZIKV. To this end, we evaluated the capacity of the epidemic strain BeH819015 to infect epithelial A549 and neuronal SH-SY5Y cells in comparison to the African historical MR766 strain. For that purpose, w...
16 CitationsSource
#2Alexia Ndebo (University of Geneva)H-Index: 1
Last.Marjolaine RocheH-Index: 6
view all 10 authors...
Zika virus (ZIKV) is a mosquito-borne flavivirus that recently emerged in the South Pacific, Americas, and Caribbean islands, where the larger epidemics were documented. ZIKV infection in humans is responsible for neurological disorders and microcephaly. Flavivirus NS1 is a non-structural glycoprotein that is expressed on the cell surface and secreted as a hexameric lipoprotein particle. Intracellular NS1 exists as a dimer that is required for viral replication, whereas the secreted NS1 hexamer ...
3 CitationsSource
#1Wildriss Viranaicken (University of La Réunion)H-Index: 8
#2Brice Nativel (University of La Réunion)H-Index: 6
Last.Philippe Desprès (University of La Réunion)H-Index: 50
view all 9 authors...
Abstract Available rapid, simple and accurate methods for detection and diagnosis of emerging viral diseases are required. Recently, there was an urgent need for specific antibodies against mosquito-borne Zika virus (ZIKV), which is an emerging zoonotic disease of medical concern in different regions of the world. Here, we showed that overexpression of ZIKV antigens in ClearColi BL21(DE3), a bacteria strain expressing a non-endotoxic form of LPS, is suitable for the production of specific ZIKV a...
5 CitationsSource
#1Pascale Krejbich-Trotot (University of La Réunion)H-Index: 10
#2Essia Belarbi (French Institute of Health and Medical Research)H-Index: 3
Last.Gilles Gadea (University of La Réunion)H-Index: 17
view all 8 authors...
Alphaviruses such as Chikungunya and Ross River (RRV) viruses are associated with persistent arthritis and arthralgia in humans. Monocytes and macrophages are believed to play an important role in alphaviral arthritides. In this study, we evaluated RRV permissiveness of the human acute leukemia MM6 cell line. Viral growth analysis showed that RRV infection of MM6 cells resulted in a very low virus progeny production with daily output. Using recombinant RRV expressing the reporter gene Renilla lu...
3 CitationsSource
12