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Jie Feng
Zhejiang University
27Publications
7H-index
252Citations
Publications 26
Newest
#1Chunchun Wang (ZJU: Zhejiang University)H-Index: 4
#2Zhuojun Shen (ZJU: Zhejiang University)H-Index: 1
Last.Caihong Hu (ZJU: Zhejiang University)H-Index: 22
view all 8 authors...
Abstract This study evaluated the effects of tributyrin supplementation on the growth performance, intestinal microflora and barrier function of weaned pigs. A total of 144 piglets (Duroc × (Landrace × Yorkshire), average initial weight of 6.82 kg weaned at 24 ± 1 day) were allotted to 4 treatments for 2 weeks, each of which had 6 pens with 6 pigs per pen (3 barrows and 3 gilts). The four treatments were the control (basal diet), and the basal diet supplemented with 250, 500 and 750 mg/kg tribut...
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#1Qing Liu (ZJU: Zhejiang University)H-Index: 2
#2Yuanling Zhao (ZJU: Zhejiang University)H-Index: 1
Last.Xinxia Wang (ZJU: Zhejiang University)H-Index: 12
view all 11 authors...
ABSTRACTObesity is becoming a global problem. Research into the detailed mechanism of adipocyte development is crucial for the treatment of excess fat. Zinc finger protein 217 plays roles in adipog...
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#1Xiaonan YuH-Index: 2
Last.Jie FengH-Index: 7
view all 5 authors...
This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intestinal cells. The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport. The results showed that the intracellular labile iron increased significantly with Fe-Gly or FeSO4 treatment, and this phenome...
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#1Zhao Zhuo (ZJU: Zhejiang University)H-Index: 5
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
view all 5 authors...
This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of the following dietary treatments: control group (basal diet with no extra iron addition), FeSO4 group (basal diet + 100 mg Fe/kg as FeSO4), Fe-Gly group (basal diet + 100 mg Fe/kg a...
1 CitationsSource
#1Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
#2Jianan Han (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
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Background This experiment was conducted to study the effect of different feed enzymes (phytase, xylanase, β-glucanase) on release rate of trace elements (Fe, Cu, Mn and Zn) in 6 commonly used feedstuffs (corn, wheat, barley, soybean meal, wheat bran, wheat middlings) by using an in vitro model, simulating the digestive processes in stomach for 2 h and then in small intestine for 6 h at 39 °C.
2 CitationsSource
#1Xinxia Wang (ZJU: Zhejiang University)H-Index: 12
#2Baofa Sun (Beijing Institute of Genomics)H-Index: 2
Last.Yizhen Wang (ZJU: Zhejiang University)H-Index: 24
view all 10 authors...
N6-methyladenosine (m6A) modification of mRNA plays an important role in regulating adipogenesis. However, its underlying mechanism remains largely unknown. Using Jinhua and Landrace pigs as fat and lean models, we presented a comprehensive transcriptome-wide m6A profiling in adipose tissues from these two pig breeds. Two differentially methylated genes were selected to explore the mechanisms of m6A-mediated regulation of gene function. The ratio of m6A/A in the layer of backfat (LB) was signifi...
6 CitationsSource
#1Weiche Wu (ZJU: Zhejiang University)H-Index: 5
#2Sisi Wang (ZJU: Zhejiang University)H-Index: 2
Last.Yizhen Wang (ZJU: Zhejiang University)H-Index: 24
view all 7 authors...
Betaine, a neutral zwitterionic compound, could regulate intramuscular fat (IMF) deposition and meat quality. However, the efficacy is controversial. Moreover, the regulatory mechanism of betaine on lipid metabolism in skeletal muscle cells remains unclear. Therefore, in this study, we examined the effects and regulatory mechanism of betaine on lipid accumulation in adipogenic-differentiated C2C12 cells. We found that adipogenic-induced C2C12 cells treated with 10 mM betaine for 24 and 48 h had ...
3 CitationsSource
#1Shenglin Fang (ZJU: Zhejiang University)H-Index: 6
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
view all 5 authors...
Abstract Iron overload causes many diseases, while the underlying etiologies of these diseases are unclear. Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS). However, whether the accumulation of intracellular iron itself induces ferroptosis or other forms of cell death is largely elusive. In presen...
7 CitationsSource
#1Haichao WangH-Index: 1
#2Sisi LiH-Index: 1
Last.Jie FengH-Index: 7
view all 5 authors...
To investigate the role of betaine in the intestinal functions of high-salt stressed rats, 32 four-week-old male Sprague–Dawley rats weighing 128.0 (SD 5.06) g were randomly allotted to four groups. The control group was fed with standard chow diet (0.4% NaCl), while the treatment groups were fed a high-salt diet (4.0% NaCl) supplemented with betaine at 0.0%, 0.5%, and 1.0%, respectively. The experiment lasted 28 days. The results showed that rats in the high-salt stressed groups had a significa...
3 CitationsSource
#1Weiche Wu (ZJU: Zhejiang University)H-Index: 5
#2Ziye Xu (ZJU: Zhejiang University)H-Index: 4
Last.Yizhen Wang (ZJU: Zhejiang University)H-Index: 24
view all 8 authors...
Excessive intramyocellular triacylglycerols (IMTGs, muscle lipids) are associated with the abnormal energy metabolism and insulin resistance of skeletal muscle. AMP-activated protein kinase (AMPK), a crucial cellular energy sensor, consists of α, β and γ subunits. Researchers have not clearly determined whether Prkaa1 (also known as AMPKα1) affects IMTG accumulation in skeletal muscle. Here, we show an important role of Prkaa1 in skeletal muscle lipid metabolism. Deletion of muscle Prkaa1 leads ...
2 CitationsSource
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