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Alejandro Arias-Vasquez
Radboud University Nijmegen
PsychiatryPsychologyAttention deficit hyperactivity disorderGeneticsBiology
91Publications
24H-index
1,892Citations
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Publications 98
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#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
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Objective:Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with intellectual disability, and shared overlapping genetics...
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Background Impulsivity and compulsivity are related to emotional and social maladjustment and often underlie psychiatric disorders. Recently, alterations in microbiota composition have been shown to have implications for brain development and social behavior via the microbiota–gut–brain axis. However, the exact mechanisms are not fully identified. Recent evidence suggests the modulatory effect of synbiotics on gut microbiota and the contribution of these agents in ameliorating symptoms of many p...
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#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Sarita A. Dam (Radboud University Nijmegen)
Last. Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
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Abstract Learning from feedback is one of the key mechanisms within cognitive flexibility, which is needed to react swiftly to constantly changing environments. The motivation to change behavior is highly dependent on the expectancy of positive (reward) or negative (punishment) feedback. Individuals with conduct disorder (CD) with high callous unemotional traits show decreased sensitivity to negative feedback and increased reward seeking. Previous studies have modelled traits associated with CD ...
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#1Wenhao Jiang (GSU: Georgia State University)H-Index: 1
#2Kuaikuai Duan (Georgia Institute of Technology)
Last. Jessica A. Turner (GSU: Georgia State University)H-Index: 53
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Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals with subthreshold ADHD (N = 49), and unrelated healthy controls (N = 141) with an age range from 7 to 18 years old from 336 families in the Dutch NeuroIMAGE project. Source based morp...
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#2Mark J. TaylorH-Index: 9
Last. Catharina A. HartmanH-Index: 52
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#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
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Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysi...
5 CitationsSource
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
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