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Judith U. Harrer
Physical therapyThrombolysisStrokeDiabetes mellitusMedicine
8Publications
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19Citations
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Publications 8
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Markers of subclinical vascular disease, including arterial stiffness and carotid intima-media thickness, are seen as emerging markers of arterial aging and may serve as risk markers for brain injury and vascular cognitive impairment.1 Arterial stiffening, especially of the aorta, plays a key role in the initiation and progression of hypertension. It also directly relates the effects of hypertension to peripheral organs, with dire consequences for organs with extensive microvasculature like the ...
1 CitationsSource
The study by Xian et al.,1 published in JAMA (June 27, 2012), adds to the growing literature on the safety of IV thrombolysis among stroke patients undergoing anticoagulation treatment. This study, which uses data from the American Heart Association Get With The Guidelines (GWTG)–Stroke Registry, concluded that there was no association between IV thrombolysis and symptomatic intracranial hemorrhage (SICH).1 These findings are in agreement with some2–4 but contrast with other studies (including 2...
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IV thrombolysis is the only approved therapy for acute ischemic stroke. Clinical benefit for approximately 1 in 7 treated patients results when administered within 4.5 hours of stroke onset.1,2 The widespread use of IV thrombolysis is, however, hindered by symptomatic intracranial hemorrhage (sICH), which affects 2%–8% of patients (depending on the definition of sICH employed). While several factors clearly enhance the risk for sICH (such as age, NIH Stroke Scale score, and onset to treatment ti...
2 CitationsSource
Diagnostic findings derived from MRI, and other state-of-the-art clinical tools, share the disadvantage of providing only a static snapshot of lesions or disease, thus rendering the evaluation of their importance in correlation to symptoms difficult. Through the example of poststroke depression, Lassalle-Lagadec and colleagues provide an impressive demonstration of how mobile technologies are able to overcome this barrier and may signal the arrival of a methodologic revolution in the field of ne...
1 CitationsSource
Transcranial sonography (TCS) is widely used to evaluate brain structures and intracranial vessels, with recent developments allowing high-resolution and dynamic imaging. Color-coded duplex sonography is mostly used to investigate the basal cerebral arteries and plays an important role in stroke diagnostics1 and in intensive care medicine,2 while B-mode sonography is generally used for evaluation of the brain parenchyma. Transcranial B-mode sonography emerged in the early 1990s and is in widespr...
3 CitationsSource
Stroke is the second or third leading cause of death worldwide and a major cause of disability. Immediate treatments to reverse ischemic damage may markedly improve outcomes. Currently, alteplase is the only licensed treatment for acute ischemic stroke, with a time window of 3 hours from the onset of symptoms: based on the promising results from the European Cooperative Acute Stroke Study III (ECASS III),1 the treatment window may be extended to 4.5 hours. However, only 2% of all stroke patients...
4 CitationsSource
Migraine has long been considered a painful condition that affects quality of life but is not otherwise dangerous. A number of case-control and cohort studies, however, indicated that migraineurs, particularly those with aura, have a higher risk of ischemic but not hemorrhagic stroke.1 Further, the relationship between migraine (in particular with aura) and stroke was verified in 2 large prospective cohorts: the Women's Health Study2 and the Physicians' Health Study.3 These large-scale cohort st...
4 CitationsSource
During the last two decades, evidence has shown an association between patent foramen ovale (PFO) and cryptogenic stroke, predominantly in younger patients. In a meta-analysis of case-control studies, approximately 35%–50% of patients with cryptogenic ischemic stroke had a PFO, vs only 4%–10% of age-matched patients. That is a fivefold increase risk of cryptogenic stroke in younger patients with PFO.1 However, causality and its recurrence seem to be more complex, considering that 27% of the gene...
4 CitationsSource
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