Yoko Kurotaki
Central Institute for Experimental Animals
Publications 6
#1Wakako Kumita (Central Institute for Experimental Animals)H-Index: 2
#2Kenya Sato (Central Institute for Experimental Animals)H-Index: 3
Last.Yasubumi Sakakibara (Keio: Keio University)H-Index: 29
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Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency of CRISPR/Cas9 has not been extensively investigated in marmosets. In this study, optimum conditions for target gene modification efficacies of CRISPR/mRNA and CRISPR/nuclease in marmoset embryos were examined. CRISPR/nuclease was more effective than CRISPR/mRNA in avoiding mosai...
#1Akiko Uematsu (Central Institute for Experimental Animals)H-Index: 2
#2Jun-ichi Hata (Central Institute for Experimental Animals)H-Index: 40
Last.Hideyuki Okano (Keio: Keio University)H-Index: 110
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Abstract Brain development involves spatiotemporally complex microstructural changes. A number of neuropsychiatric disorders are linked to the neural processes of development and aging. Thus, it is important to understanding the typical developmental patterns of various brain structures, which will help to define critical periods of vulnerability for neural maturation, as well as anatomical mechanisms of brain structure-related neuropathology. In this study, we used magnetic resonance imaging to...
#1Yoko Kurotaki (Central Institute for Experimental Animals)H-Index: 2
#2Erika Sasaki (Central Institute for Experimental Animals)H-Index: 20
Abstract: The common marmoset (Callithrix jacchus) is commonly used as a subject model animal in experimental research. The species has several advantages compared with other laboratory primates and we succeeded in creating a transgenic (Tg) marmoset with germline transmission of the transgene, the first time in a nonhuman primate. We have been attempting to further improve marmoset reproductive technology, which is more similar to that of humans than rodent experimental animals, such as mice. W...
#1Yoko Kurotaki (University of Tsukuba)H-Index: 2
#2Yuki HatanakaH-Index: 9
Last.Atsuo Ogura (UTokyo: University of Tokyo)H-Index: 57
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