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Qianyi Wang
Tufts University
EndocrinologyCardiologyType 2 diabetesDiabetes mellitusMedicine
10Publications
4H-index
170Citations
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Publications 11
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In the article by Wang et al, “Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease,” which published online January 20, 2016, and appeared in the January 2016 issue of the journal ( J Am Heart Assoc . 2016;5:e002891 doi:10.1161/
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#1Qianyi Wang (Tufts University)H-Index: 4
#2Ashkan Afshin (Tufts University)H-Index: 33
Last. Gábor ZajkásH-Index: 1
view all 116 authors...
Background Saturated fat (SFA), ω‐6 (n‐6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear. Methods and Results National intakes of SFA, n‐6 PUFA, and TFA were estimated using a Bayesian hierarchical model based on country‐specific dietary surveys; food availability data; and, for TFA, industry reports on fats/oils and packaged foods. Etiologic effects of dietary fats on CHD...
34 CitationsSource
#1Qianyi WangH-Index: 4
#2Ashkan AfshinH-Index: 33
Last. Katia CastetbonH-Index: 38
view all 10 authors...
#1Qianyi WangH-Index: 4
#2Fumiaki ImamuraH-Index: 27
Last. Dariush MozaffarianH-Index: 120
view all 13 authors...
Source
#1Qianyi Wang (Harvard University)H-Index: 4
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last. Dariush Mozaffarian (Tufts University)H-Index: 120
view all 13 authors...
Source
#1Qianyi Wang (Harvard University)H-Index: 4
#2Fumiaki Imamura (Medical Research Council)H-Index: 27
Last. Dariush Mozaffarian (Tufts University)H-Index: 120
view all 13 authors...
OBJECTIVE To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS In the Cardiovascular Health Study, plasma phospholipid trans ( t )-16:1n9, t -18:1, and cis ( c ) /t - , t/c - , and t/t -18:2 were measured in blood drawn from 2,919 adults aged 74 ± 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were...
16 CitationsSource
#1Wenjie Ma (Harvard University)H-Index: 9
#2Jason H.Y. Wu (USYD: University of Sydney)H-Index: 35
Last. Dariush Mozaffarian (Tufts University)H-Index: 120
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Background: Experimental evidence suggests that hepatic de novo lipogenesis (DNL) affects insulin homeostasis via synthesis of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Few prospective studies have used fatty acid biomarkers to assess associations with type 2 diabetes. Objectives: We investigated associations of major circulating SFAs [palmitic acid (16:0) and stearic acid (18:0)] and MUFA [oleic acid (18:1n–9)] in the DNL pathway with metabolic risk factors and incid...
84 CitationsSource
#1Qianyi Wang (Harvard University)H-Index: 4
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last. Dariush MozaffarianH-Index: 120
view all 9 authors...
Background While self-reported trans– fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes ( t- 16:1n9, total t- 18:1, and cis / trans- ( c / t- ), t / c- and t / t- 18:2) and cardiovascular disease (CVD) or total mortality are not well established. Methods and Results We evaluated 2742 adults in the Cardiovascular Health Study, aged 74±5 years and free of prevalent CVD, with plasma phospholipid TFA measures in 1992. I...
36 CitationsSource
#1Wenjie Ma (Harvard University)H-Index: 9
#2Jason H.Y. WuH-Index: 35
Last. Dariush Mozaffarian (Harvard University)H-Index: 120
view all 14 authors...
Background: Experimental evidence suggests de novo lipogenesis (DNL) affects insulin homeostasis via synthesis of saturated (SFA) and monounsaturated fatty acids (MUFA), and also through altered activity of the key regulatory enzyme, Stearoyl-CoA desaturase-1 (SCD-1). Only limited studies have utilized biomarkers of SFA, MUFA and estimated SCD-1 activity to assess their prospective association with risk of type 2 diabetes (T2D). Objective: To investigate the association of 3 major circulating SF...
#1Qianyi Wang (Harvard University)H-Index: 4
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last. Dariush Mozaffarian (Harvard University)H-Index: 120
view all 12 authors...
Background: While trans-fatty acids (TFA) influence CHD, their effects on type 2 diabetes mellitus (DM) are not established, with mixed findings of experimental, short-term intervention, and observational studies. Effects may vary depending on specific TFA subtype or method of assessment (circulating biomarkers vs. diet). Objectives: To examine prospective associations of circulating and estimated dietary TFA with risk of incident DM in older adults. Methods: Plasma phospholipid trans-(t-)16:1n9...
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