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Graham J. Hickman
Nottingham Trent University
10Publications
4H-index
33Citations
Publications 11
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#2Graham J. HickmanH-Index: 4
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OPCT-1 is a heterogeneous prostate cancer cell line derived from primary (rather than metastatic) disease which contains epithelial, mesenchymal and CD44high/CD24low cancer stem cell (CSC) sub-populations and from which we have previously generated and characterized stable mesenchymal (P4B6B) and epithelial (P5B3) cell sub-populations. In this contribution, we explore the effect of tissue culture surface chemistry (standard tissue culture plastic (TCP) and a fluoroalkylsilica (FS) culture surfac...
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#1Graham J. Hickman (NTU: Nottingham Trent University)H-Index: 4
#2David J. Belton (NTU: Nottingham Trent University)H-Index: 11
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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There is an increasing demand for environmentally sustainable sourcing of ingredients for the food, pharmaceutical and supplements industries. In the case of calcium carbonate (E170) as by-products from the egg and shellfish processing industries these have the potential to be sustainably sourced. In addition to their green credentials, biogenic carbonates have intrinsic benefits in terms of their chemical composition, such as a low heavy metal burden. However, their biogenic origin can potentia...
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#1Victor V. Volkov (NTU: Nottingham Trent University)H-Index: 8
#2Graham J. Hickman (NTU: Nottingham Trent University)H-Index: 4
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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Equisetum species are primitive vascular plants that benefit from the biogenesis of silica bio-organic inclusions in their tissues and participate in the annual biosilica turnover in local eco-systems. As means of Equisetum reproduction and propagation, spores are expected to reflect the evolutionary adaptation of the plants to the climatic conditions at different times of the year. Combining methods of Raman and scanning electron microscopy and assisted with density functional theory, we conduc...
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#1David J. Belton (NTU: Nottingham Trent University)H-Index: 11
#2Graham J. Hickman (NTU: Nottingham Trent University)H-Index: 4
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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ABSTRACTCalcium carbonate (E170) is a common food and pharmaceutical additive/ingredient. In addition to a source of calcium, the carbonate has uses including as a colour, acidity regulator and bulking agent. Globally, a range of regulatory agencies and pharmacopoeia control the analyses and specification of additives in food, supplements, pharmaceutical substances and excipients. Accordingly, a range of specifications and analyses exist for calcium carbonate depending on the application and mar...
1 CitationsSource
#1Anna Sola-Rabada (NTU: Nottingham Trent University)H-Index: 4
#2Padma Sahare (UMSNH: Universidad Michoacana de San Nicolás de Hidalgo)H-Index: 1
Last.Vivechana Agarwal (Universidad Autónoma del Estado de Morelos)H-Index: 16
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Abstract Porous silica-based materials are attractive for biomedical applications due to their biocompatibility and biodegradable character. In addition, inorganic supports such as porous silicon are being developed due to integrated circuit chip compatibility and tunable properties leading to a wide range of multidisciplinary applications. In this contribution, biosilica extracted from a rarely studied plant material (Equisetum Myriochaetum), its conversion to silicon and the potential for both...
4 CitationsSource
#1Vadim V. Annenkov (RAS: Russian Academy of Sciences)H-Index: 13
#2Elena N. Danilovtseva (RAS: Russian Academy of Sciences)H-Index: 12
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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Abstract Siliceous frustules of diatom algae contain unique long-chain polyamines, including those having more than six nitrogen atoms. These polyamines participate in the formation of the siliceous frustules of the diatoms but their precise physiological role is not clear. The main hypotheses include formation of a polyamine and polyphosphate supramolecular matrix. We have synthesized novel fluorescent dyes from a synthetic oligomeric mixture of polyamines and the fluorophore 7-nitro-2,1,3-benz...
3 CitationsSource
Cell and tissue culture has evolved from the use of simple glassware for the propagation of cells and tissues into a comprehensive platform for interrogating complex biological systems, directing cell fate, and deriving products with clinical and therapeutic value. However, despite significant advances, current in vitro culture approaches remain limited in their capacity to model the clinical/biological complexities of disease, in part at least, due to the deficiencies of existing culture materi...
9 CitationsSource
#1Graham J. Hickman (NTU: Nottingham Trent University)H-Index: 4
#2Robert C. Rees (NTU: Nottingham Trent University)H-Index: 42
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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Developing materials that can preferentially select defined cancer cell populations for biological characterization will greatly enhance our understanding of cancer cell growth, differentiation, and invasion. The transitional events between epithelial and mesenchymal phenotypes are particularly crucial, as primary tumors and secondary metastasis are generally epithelial in nature, whereas circulating mesenchymal cells derived from primary epithelial cells appear to facilitate the spread of disea...
1 CitationsSource
#1A. A. El hadad (CSIC: Spanish National Research Council)H-Index: 2
#2Violeta Barranco (CSIC: Spanish National Research Council)H-Index: 20
Last.Carole C. Perry (NTU: Nottingham Trent University)H-Index: 46
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The biocompatibility and life of metallic implants can be enhanced through improving the biocompatibility and corrosion protection characteristics of the coatings used with these materials. In this study, triethylphosphite (TEP) was used to introduce phosphorus into organic–inorganic hybrid silica based sol–gel coatings prepared using γ-methacryloxypropyltrimethoxysilane and tetramethylorthosilicate. Addition of TEP dramatically increased the rate of intermolecular condensation and resulted in m...
2 CitationsSource
#1A. A. El hadad (NTU: Nottingham Trent University)H-Index: 2
#2Violeta Barranco (CSIC: Spanish National Research Council)H-Index: 20
Last.Juan Carlos Galván (CSIC: Spanish National Research Council)H-Index: 21
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Application of novel organic–inorganic hybrid sol–gel coatings containing dispersed hydroxyapatite (HAp) particles improves the biocompatibility, normal human osteoblast (NHOst) response in terms of osteoblast viability and adhesion of a Ti6Al4V alloy routinely used in medical implants. The incorporation of HAp particles additionally results in more effective barrier proprieties and improved corrosion protection of the Ti6Al4V alloy through higher degree of cross-linking in the organopolysiloxan...
8 CitationsSource
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