Match!
Anita Somborac-Bačura
University of Zagreb
9Publications
3H-index
71Citations
Publications 10
Newest
#1Iva Hlapčić (University of Zagreb)
#2Anita Somborac-Bačura (University of Zagreb)H-Index: 3
Last.Lada RumoraH-Index: 13
view all 8 authors...
Introduction Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that can affect haemostasis. This study aimed to determine differences in platelet-related parameters between controls and COPD subjects. The hypothesis was that platelet indices are disturbed in COPD patients, and this would be accompanied by increased C-reactive protein (CRP), fibrinogen (Fbg) and white blood cells (WBC). Therefore, platelet count (Plt), platelet-related parameters – mean platelet vol...
Source
#1Iva Hlapčić (University of Zagreb)
#2Andrea Hulina-Tomašković (University of Zagreb)H-Index: 2
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 7 authors...
Extracellular adenosine triphosphate (eATP)-driven inflammation was observed in chronic obstructive pulmonary disease (COPD) but was not investigated in patients’ blood. Therefore, this study aimed to investigate eATP concentration in plasma of COPD patients and its association with disease severity and smoking. Study included 137 patients with stable COPD and 95 control subjects. eATP concentration was determined in EDTA plasma by luminometric method, and mRNA expression of eATP receptors P2X7R...
Source
#1Andrea Hulina-Tomašković (University of Zagreb)H-Index: 2
#2Anita Somborac-Bačura (University of Zagreb)H-Index: 3
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 6 authors...
Abstract Extracellular Hsp70 (eHsp70) can act as pro-inflammatory mediator and is elevated in blood of chronic obstructive pulmonary disease (COPD) patients. Most of those patients are smokers, and it was suggested previously that cigarette smoke might induce Hsp70 secretion from the circulating cells. Therefore, we aimed to explore inflammation-associated effects of cigarette smoke extract (CSE) and its combinations with eHsp70 in monocyte-derived macrophages (MDMs) and THP-1 cell line, used as...
Source
#1Andrea Hulina-Tomašković (University of Zagreb)H-Index: 2
#2Irene H. Heijink (UMCG: University Medical Center Groningen)H-Index: 26
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 6 authors...
Abstract Extracellular Hsp70 (eHsp70) can activate immune cells via Toll-like receptors (TLR) 2 and 4, and induce cytokine synthesis. The aim of this study was to explore inflammation-associated effects of eHsp70 alone and in combination with cigarette smoke extract (CSE) in primary bronchial epithelial cells. We assessed IL-6 and IL-8 concentrations, TLR2, TLR4 and Hsp70 mRNA expressions, and mitogen-activated protein kinases (MAPKs) activation induced by recombinant human (rh) Hsp70, CSE or th...
3 CitationsSource
#1Andrea Hulina-Tomašković (University of Zagreb)H-Index: 2
#2Marija Grdić Rajković (University of Zagreb)H-Index: 5
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 6 authors...
One of the major risk factors for development of chronic obstructive pulmonary disease (COPD) is cigarette smoke. Extracellular Hsp70 (eHsp70) is increased in sera of COPD patients, and can act as damage-associated molecular pattern (DAMP). In this study, we explored inflammatory parameters (cytokine concentrations, Toll-like receptor (TLR) 2 and 4 and Hsp70 expression, mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) activation, and cytotoxicity) after exposure of bronchi...
2 CitationsSource
#1Anita Somborac-Bačura (University of Zagreb)H-Index: 3
#2Lada Rumora (University of Zagreb)H-Index: 13
Last.Tihana Žanić-Grubišić (University of Zagreb)H-Index: 10
view all 7 authors...
3 CitationsSource
#1Anita Somborac-Bačura (University of Zagreb)H-Index: 3
#2Sanja Popović-Grle (University Hospital Centre Zagreb)H-Index: 9
Last.Tihana Žanić-Grubišić (University of Zagreb)H-Index: 10
view all 4 authors...
Introduction Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Exposure to cigarette smoke may stimulate inflammatory response and activate polymorphonuclear leukocytes (PMN) thus resulting in secretion of cellular proteases. The aim of our study was to explore the effect of cigarette smoke extract (CSE) on the release of matrix metalloproteinase-9 (MMP-9) from PMN.
6 CitationsSource
#1Ognjen Čulić (University of Zagreb)H-Index: 11
#2Cordero (University of Seville)H-Index: 1
Last.Karmela Barišić (University of Zagreb)H-Index: 12
view all 8 authors...
Fibromyalgia (FM) is a chronic pain syndrome with number of symptoms that present challenge in terms of diagnosis and treatment. Patients with FM show abnormal profile of purines in plasma. In this work, we measured serum activities of enzymes involved in purine metabolism, namely total adenosine deaminase (ADE) and its isoforms (ADE1 and ADE2), ecto-ATPase, and 5′-nucleotidase (5′-NT). We also measured activity of dipeptidyl peptidase IV (DPPIV) and prolyl endopeptidase (PEP). Spectrophotometri...
2 CitationsSource
#1Anita Somborac-Bačura (University of Zagreb)H-Index: 3
#2Marco van der Toorn (UMCG: University Medical Center Groningen)H-Index: 12
Last.Antoon J. M. van Oosterhout (UMCG: University Medical Center Groningen)H-Index: 42
view all 7 authors...
New findings • What is the central question of this study?The endoplasmic reticulum stress response caused by cigarette smoke may lead to excessive apoptosis with disruption of the epithelial barrier, thus contributing to chronic obstructive pulmonary disease. One way of promoting cell survival is to facilitate degradation of cigarette smoke-induced protein damage through the ubiquitin–proteasome pathway. Direct effects of gas-phase cigarette smoke on proteasomal activities have not been demonst...
45 CitationsSource
#1Anita Somborac-Bačura (University of Zagreb)H-Index: 3
#2Sunčica Buljević (University of Rijeka)H-Index: 6
Last.Tihana Žanić-Grubišić (University of Zagreb)H-Index: 10
view all 10 authors...
Abstract Objectives The objective of this study was to measure soluble dipeptidyl peptidase IV (sDPPIV) activity in sera of patients with stable chronic obstructive pulmonary disease (COPD) in comparison to healthy controls. The main goal was to assess changes in the enzyme activity in relation to severity of the disease, age and smoking history and to evaluate diagnostic accuracy for prediction of COPD by level of serum sDPPIV activity. Design and methods The study included 106 patients with st...
10 CitationsSource
1