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Jiyuan Chen
University of Texas Health Science Center at Houston
7Publications
5H-index
61Citations
Publications 7
Newest
#1Zhen Zhou (WHU: Wuhan University)H-Index: 1
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 9 authors...
Objective— Pharmacological inhibition of the AT1R (angiotensin II type 1 receptor) with losartan can attenuate ascending aortic remodeling induced by transverse aortic constriction (TAC). In this s...
1 CitationsSource
#1Callie S. Kwartler (University of Texas Health Science Center at Houston)H-Index: 13
#2Li-MinGONG (University of Texas Health Science Center at Houston)H-Index: 23
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 12 authors...
Thoracic aortic aneurysms leading to acute aortic dissections are a preventable cause of premature deaths if individuals at risk can be identified. Individuals with early-onset aortic dissections without a family history or syndromic features have an increased burden of rare genetic variants of unknown significance (VUSs) in genes with pathogenic variants for heritable thoracic aortic disease (HTAD). We assessed the role of VUSs in the development of disease using both in vitro enzymatic assays ...
5 CitationsSource
Source
#1Dongchuan Guo (University of Texas Health Science Center at Houston)H-Index: 33
#2Ellen S. Regalado (University of Texas Health Science Center at Houston)H-Index: 25
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 17 authors...
The major diseases affecting the thoracic aorta are aneurysms and acute dissections, and pathogenic variants in 11 genes are confirmed to lead to heritable thoracic aortic disease. However, many families in which multiple members have thoracic aortic disease do not have alterations in the known aortopathy genes. Genes highly expressed in the aorta were assessed for rare variants in exome sequencing data from such families, and compound rare heterozygous variants (p.Pro45Argfs ∗ 25 and p.Glu750 ∗...
11 CitationsSource
#1Jiyuan Chen (University of Texas Health Science Center at Houston)H-Index: 5
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 20 authors...
Rationale: Mutations in ACTA2 , encoding the smooth muscle isoform of α-actin, cause thoracic aortic aneurysms, acute aortic dissections, and occlusive vascular diseases. Objective: We sought to identify the mechanism by which loss of smooth muscle α-actin causes aortic disease. Methods and Results: Acta2 −/− mice have an increased number of elastic lamellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography that can be attenuated by treatment with losart...
16 CitationsSource
#1Jiyuan Chen (University of Texas Health Science Center at Houston)H-Index: 5
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 20 authors...
Rationale: Mutations in ACTA2, encoding the smooth muscle isoform of α-actin (SM α-actin), cause thoracic aortic aneurysms, acute aortic dissections, and occlusive vascular diseases. Objective: We sought to identify the mechanism by which loss of SM α-actin causes aortic disease. Methods and Results: Acta2 -/- mice have an increased number of elastic lamellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography that can be attenuated by treatment with losar...
11 CitationsSource
#1Callie S. Kwartler (University of Texas Health Science Center at Houston)H-Index: 13
#2Jiyuan Chen (University of Texas Health Science Center at Houston)H-Index: 5
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 12 authors...
Duplications spanning nine genes at the genomic locus 16p13.1 predispose individuals to acute aortic dissections. The most likely candidate gene in this region leading to the predisposition for dissection is MYH11, which encodes smooth muscle myosin heavy chain (SM-MHC). The effects of increased expression of MYH11 on smooth muscle cell (SMC) phenotypes were explored using mouse aortic SMCs with transgenic overexpression of one isoform of SM-MHC. We found that these cells show increased expressi...
17 CitationsSource
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