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Jianing Zhang
Dalian University of Technology
27Publications
8H-index
175Citations
Publications 27
Newest
#1Ning Ding (DUT: Dalian University of Technology)H-Index: 1
#2Xin Fu (DUT: Dalian University of Technology)
Last.Xuejun Hu (DUT: Dalian University of Technology)H-Index: 1
view all 8 authors...
Objective To improve the production yield of N-glycosylated anti-VEGFR2 (vascular endothelial growth factor receptor 2) monobody (FN3VEGFR2-Gly) in lpp knockout Escherichia coli cells harboring Campylobacter jejuni N-glycosylation pathway.
Source
#1Yubo Liu (DUT: Dalian University of Technology)H-Index: 8
#2Xue Wang (DUT: Dalian University of Technology)H-Index: 1
Last.Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 9 authors...
1 CitationsSource
#1Cheng Zhang (DUT: Dalian University of Technology)H-Index: 1
#2Qiong Wu (DUT: Dalian University of Technology)H-Index: 4
Last.Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 8 authors...
Caveolin-1 (Cav-1) is a critical structural protein of caveolae and plays an oncogene-like role by participating in abnormal protein glycosylation in hepatocellular carcinoma (HCC). However, the mechanism by which Cav-1 regulates glycosylation and glycosyltransferase expression has not been completely defined. Here, we show that Cav-1 promotes the expression of Rfng, which is a β-1,3-N-acetylglucosaminyltransferase included in the Fringe family. In this study, we showed that the mouse HCC cell l...
Source
#1Ning Ding (DUT: Dalian University of Technology)H-Index: 1
#2Yao Ruan (DUT: Dalian University of Technology)H-Index: 1
Last.Xuejun Hu (DUT: Dalian University of Technology)H-Index: 1
view all 9 authors...
Escherichia coli has been considered as a promising host for the production of N-glycosylated therapeutic proteins and glycoconjugate vaccines. In this study, we developed a simple and efficient strategy for improving the production of N-glycosylated recombinant proteins by combining auto-induction with the use of a leaky E. coli strain. A leaky E. coli strain, designated as CLM37-Δlpp, was engineered by deleting the Braun’s lipoprotein (lpp) gene of E. coli strain CLM37. Three distinct acceptor...
Source
#1Cheng Zhang (DUT: Dalian University of Technology)H-Index: 1
#2Huang Huang (DUT: Dalian University of Technology)H-Index: 3
Last.Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 9 authors...
Since publication of this paper, the authors have noticed an error in one of the images. In Fig. 2c, the graphs of c-Myc and CREB are incorrect. During image synthesis, these two images were confused with other images from the raw data. The error does not impact the conclusions of the article. The authors would like to apologize for any inconvenience this may have caused. This has been corrected in both the PDF and HTML versions of the Article. An amendment to this paper has been published and c...
Source
#1Zhishuai Ye (Capital Medical University)H-Index: 1
#2Lei Zhong (Dalian Medical University)H-Index: 1
Last.Rongchong Huang (Capital Medical University)H-Index: 1
view all 8 authors...
P-selectin and dendritic cells (DCs) are associated with atherosclerosis. However, their interactions in this setting are undefined. Herein, we investigated the role of P-selectin and its receptor P-selectin glycoprotein ligand (PSGL)-1 on atherosclerosis via activation of DCs. In the current study, a total of 34 patients with ST elevation myocardial infarction (STEMI) and 34 healthy control subjects were enrolled. Serum concentration of P-selectin was higher and the myeloid DC/plasmacytoid DC (...
2 CitationsSource
#1Cheng Zhang (DUT: Dalian University of Technology)H-Index: 25
#2Huang Huang (DUT: Dalian University of Technology)H-Index: 3
Last.Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 9 authors...
Caveolin-1 (Cav-1) is an important structural protein of caveolae and plays an oncogene-like role by influencing protein glycosylation in hepatocellular carcinoma (HCC) cells. However, the mechanism by which Cav-1 promotes invasion and metastasis capacity has not been completely clarified. In this study, we demonstrate that Pofut1 is a fucosyltransferase induced by Cav-1. Mouse Hepa1-6 HCC cells lacking Cav-1 expression exhibited low transcription levels of Pofut1, whereas strong Pofut1 expressi...
Source
#1Liping Wang (Dalian Medical University)H-Index: 4
#2Shijun Li (Dalian Medical University)
Last.Shujing Wang (Dalian Medical University)H-Index: 14
view all 9 authors...
Altered glycosylation is a common feature of cancer cells and plays an important role in tumor progression. β-Galactoside α2-6-sialyltransferase 1 (ST6Gal-I) is the critical sialyltransferase responsible for the addition of α2-6-sialic acid to the terminal N-glycans on the cell surface. However, the functions and mechanism of ST6Gal-I in tumor immune escape remain poorly understood. Here, we found that ST6Gal-I overexpression promoted hepatocarcinoma cell proliferation, migration, and immune esc...
Source
#1Siqi Zhang (DUT: Dalian University of Technology)
#2Lijuan Bai (DUT: Dalian University of Technology)
Last.Yubo Liu (DUT: Dalian University of Technology)H-Index: 8
view all 11 authors...
Abstract FOXA1 functions as a pioneer factor of transcriptional regulation that binds to specific sites in the chromatin and recruits other transcription factors, promoting the initiation of gene transcription and mediating the regulation of downstream target gene expression. FOXA1 was reported to facilitate or reprogram ERα binding, thus playing a key function in breast cancer progression. Our previous results indicated that the O-linked N-acetylgalactosamine (O-GalNAc) modification of FOXA1 pl...
Source
#1Zhishuai Ye (Capital Medical University)H-Index: 1
#2Shanfeng Zhang (Dalian Medical University)
Last.Rongchong Huang (Capital Medical University)H-Index: 1
view all 6 authors...
Background. Circulating monocytes play a critical role in the pathogenesis of atherosclerosis. Monocyte homing to sites of atherosclerosis is primarily initiated by selectin. Thus, blockade of the interaction of selectins and their ligands holds a significant role in monocyte homing which might be a potential approach to treat atherosclerosis. Here, we investigated the efficacy of a novel peptide analogue of selectin ligands IELLQAR in atherosclerosis. Methods and Results. In this study, we firs...
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