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Jianing Zhang
Dalian University of Technology
CellMolecular biologyBiochemistryBiologyCell biology
11Publications
8H-index
127Citations
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Publications 11
Newest
#1Zhishuai Ye (Dalian Medical University)H-Index: 2
#2Jia Liu (Dalian Medical University)H-Index: 1
Last. Rongchong Huang (Dalian Medical University)H-Index: 2
view all 5 authors...
Abstract The relationship between dendritic cells (DCs) and L-selectin in the progress of atherosclerosis is unclear. Here, we used L-selectin co-cultured with DCs to investigate the effect of L-selectin on the maturation of DCs in vitro Monocytes derived DCs were isolated and cultured from human peripheral blood. After being stimulated with L-selectin and/or its antagonist for 24-48 hours, the feather of cells was observed by the electron microscope. The expression of mature antigens CD1a, CD80...
2 Citations
#1Yubo Liu (DUT: Dalian University of Technology)H-Index: 9
#2Huang Huang (DUT: Dalian University of Technology)H-Index: 4
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 6 authors...
Abstract MicroRNAs (miRNAs) are endogenous non-coding regulatory RNAs involved in multiple cellular processes. Emerging evidences showed that miRNAs are involved in changing the cell surface glycosylation modification and oncogenesis. In this study, the role of miRNA-24-1 in O -GlcNAcylation and metastasis of mouse hepatocarcinoma cells was investigated. miRNAs expression array profiles were obtained from mouse hepatocarcinoma cell lines Hca-P and Hca-F with the low/high lymphatic metastasis pot...
4 CitationsSource
#1Yubo Liu (DUT: Dalian University of Technology)H-Index: 9
#2Huang Huang (DUT: Dalian University of Technology)H-Index: 4
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 6 authors...
Abstract O-GlcNAc transferase (OGT) catalyzes the addition of O-GlcNAc to certain serine or threonine residue on a wide variety of cytosolic and nuclear proteins and regulates cellular activities such as signaling and transcription. Although there are emerging evidences that OGT plays important roles in breast cancer metastasis, the underlying mechanism is not fully understood. In this study, we demonstrated that up-regulation of OGT correlates with breast cancer cells invasion. Over-expression ...
9 CitationsSource
#1Shengjin Yu (ELU: Eastern Liaoning University)H-Index: 3
#2Huiming Lv (ELU: Eastern Liaoning University)H-Index: 1
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 13 authors...
Abstract Heparanase-1/syndecan-1 axis plays critical roles in tumorigenesis and development. The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors. However, the significance of Heparanase-1/syndecan-1 axis and its effects on the microenvironment of lymphatic metastasis in hepatocellular carcinogenesis (HCC) procession have not ...
9 CitationsSource
#1Ning Ding (DUT: Dalian University of Technology)H-Index: 2
#2Chunguang Yang (DUT: Dalian University of Technology)H-Index: 1
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
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Abstract Escherichia coli cells have been considered as promising hosts for producing N -glycosylated proteins since the successful production of N -glycosylated protein in E. coli with the pgl ( N- linked protein glycosylation) locus from Campylobacter jejuni . However, one hurdle in producing N -glycosylated proteins in large scale using E. coli is inefficient glycan glycosylation. In this study, we developed a strategy for the production of N- glycosylated proteins with high efficiency via an...
10 CitationsSource
#1Yuanming Xu (NU: Northwestern University)H-Index: 9
#2Fang Zhao (NU: Northwestern University)H-Index: 4
Last. Deyu Fang (NU: Northwestern University)H-Index: 37
view all 16 authors...
National Institutes of Health R01 grants [AI079056, AI108634, AR006634]; National Natural Science Grants; Shanghai Committee of Science and Technology Grant [14DZ2260300, 81470673, 81271054]
15 CitationsSource
#1Xixi Chen (DUT: Dalian University of Technology)H-Index: 5
#1Xixi ChenH-Index: 3
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 9 authors...
// Xixi Chen 1, * , Liping Wang 2, * , Yujie Zhao 2 , Shiqi Yuan 2 , Qiang Wu 2 , Xiaoling Zhu 2 , Bachir Niang 2 , Shujing Wang 2 , Jianing Zhang 1 1 School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, Liaoning, China 2 Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian 116044, Liaoning, China * These authors have contributed equally to this work Correspondence to: Shujing Wang, email: wangshujing@dmu.e...
20 CitationsSource
#1Yi-xin Ren (Dalian Medical University)H-Index: 2
#2Shujing Wang (Dalian Medical University)H-Index: 15
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 7 authors...
Abstract T cells play an important role in tumor immune surveillance. CD147 is a member of immunoglobulin superfamily present on the surface of many tumor cells and mediates malignant cell behaviors. Cyclophilin A (CypA) is an intracellular protein promoting inflammation when released from cells. CypA is a natural ligand for CD147. In this study, CD147 specific short hairpin RNAs (shRNA) were transfected into murine hepatocellular carcinoma Hepa1-6 cells to assess the effects of CD147 on hepatom...
2 CitationsSource
#1Bachir Niang (Dalian Medical University)H-Index: 4
#2Liyuan Jin (Dalian Medical University)H-Index: 1
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 10 authors...
GALNT4 belongs to a family of N-acetylgalactosaminyltransferases, which catalyze the transfer of GalNAc to Serine or Threonine residues in the initial step of mucin-type O-linked protein glycosylation. This glycosylation type is the most complex post-translational modification of proteins, playing important roles during cellular differentiation and in pathological disorders. Most of the breast cancer subtypes are estrogen receptor positive, and hence, the estrogen pathway represents a key regula...
8 CitationsSource
#1Zhenghong Lin (NU: Northwestern University)H-Index: 11
#2Can Tan (NU: Northwestern University)H-Index: 5
Last. Deyu Fang (DUT: Dalian University of Technology)H-Index: 37
view all 14 authors...
The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discover that both USP22 and CCNB1 are dramatically elevated with a strong positive correlation in colon cancer tissues. USP22 stabilizes CCNB1 by antagonizing proteasome-mediated degradation in a cell cycle-specific manner. Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinatin...
21 CitationsSource
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