Dajun Zhao
Fourth Military Medical University
Publications 2
#1Dajun ZhaoH-Index: 2
#2Jian YangH-Index: 15
Last.Lifang YangH-Index: 4
view all 3 authors...
Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (...
31 CitationsSource
#1Lifang Yang (Fourth Military Medical University)H-Index: 4
#2Dajun Zhao (Fourth Military Medical University)H-Index: 2
Last.Jian Yang (Fourth Military Medical University)H-Index: 15
view all 4 authors...
Abstract Endoplasmic reticulum (ER) stress, together with the unfolded protein response (UPR), is initially considered an adaptive response aiming at maintenance of ER homeostasis. Nonetheless, ER stress, when in excess, can eventually trigger cell apoptosis and loss of function. UPR is mediated by three major transmembrane proteins, including inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like ER kinase (PERK), and activating transcription factor (ATF) 6. A unique role has been speculat...
54 CitationsSource